Matching of Antibiotic Resistance Patterns of Escherichia coli of Farm Families and Their Animals

Fein, Diana; Burton, Glenna C.; Tsutakawa, Robert K.; Blenden, Donald C.

doi:10.1093/infdis/130.3.274

Cited by 35 publications

(17 citation statements)

References 7 publications

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“…Resistance patterns of the avian E. coli isolates were similar to those of isolates from humans who were closely associated with the modern battery poultry. This is in agreement with the findings of Wells & James (19), Fein and colleagues (20) and Marsik and colleagues (7). The results reported here indicate a direct avian to human transmission of E. coli K12 J5 NA+Lac-which was experimentally orally inoculated into the birds and subsequently recovered from the workers who manned the experimental pen.…”

Section: D)isctusstonsupporting

confidence: 93%

“…Such non-therapeutic uses have been of major concern to those engaged in the treatment of infectious diseases, especially as a correlation has been found between the widespread use of antimicrobial drugs and the emergence of drug resistance (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Thus, resistance patterns of animal E. coli isolates have been found to be similar to those found among the isolates from humans who were closely associated with the animals (7,14,(17)(18)(19)(20). In the tropical developing countries, where antibiotics are very readily available without a prescription, and where the environmental sanitation is poor, cross infection, which was reported in Britain by Linton (12) and in the United States by Levy and colleagues (21) and Holmberg and co-workers (18), could conceivably occur on a large scale.…”

Section: Introductionmentioning

confidence: 89%

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Direct transmission of Escherichia coli from poultry to humans

Ojeniyi

1989

Epidemiol. Infect.

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SUMMARYEight hundred and sixty-four Escherichia coli isolates from workers at the University of Ibadan Teaching and Research Poultry Farm, and 216 isolates from poultry attendants at a commercial poultry farm in the city were found to be resistant to streptomycin, sulphafurazole and tetracycline. In contrast, all 576 and 288 E. coli isolates from village fowls and from villagers respectively were sensitive to these drugs. Isolates from birds in a modern university poultry unit (3744) exhibited the same resistance patterns as those isolated from workers who were in direct contact with the birds. No nalidixic acid-resistant E. coli was isolated from farm workers prior to their assignment to the experimental pen. Following experimental oral infection of birds with E. coli K12 J5 NA Lac, the organism was recovered from the workers who manned the experimental pen. Neither before nor after the experimental infection was any nalidixic acid resistant E. coli isolated from workers who manned the pen from which birds used in the experiment were selected. Similarly, no drug resistant organisms were isolated from workers outside the poultry unit of the university or commercial farm. The MIC of the drugs against the avian and human E. coli isolates at the university and commercial poultry farms were similar.

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Section: D)isctusstonsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Direct transmission of Escherichia coli from poultry to humans

Ojeniyi

1989

Epidemiol. Infect.

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“…The rapid and wide dissemination of this gene in cattle as well as in food, pets, and environments (138)(139)(140)(141)(142) is also paralleled by recent observations made for CTX-M (143). The commu-nity certainly appears to be the major reservoir of CTX-M-type ESBL (Fig.…”

Section: Discussionmentioning

confidence: 71%

Trends in Human Fecal Carriage of Extended-Spectrum β-Lactamases in the Community: Toward the Globalization of CTX-M

et al. 2013

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SUMMARY In the last 10 years, extended-spectrum β-lactamase-producing enterobacteria (ESBL-E) have become one of the main challenges for antibiotic treatment of enterobacterial infections, largely because of the current CTX-M enzyme pandemic. However, most studies have focused on hospitalized patients, though today it appears that the community is strongly affected as well. We therefore decided to devote our investigation to trends in ESBL-E fecal carriage rates and comprehensively reviewed data from studies conducted on healthy populations in various parts of the world. We show that (i) community ESBL-E fecal carriage, which was unknown before the turn of the millennium, has since increased significantly everywhere, with developing countries being the most affected; (ii) intercontinental travel may have emphasized and globalized the issue; and (iii) CTX-M enzymes, especially CTX-M-15, are the dominant type of ESBL. Altogether, these results suggest that CTX-M carriage is evolving toward a global pandemic but is still insufficiently described. Only a better knowledge of its dynamics and biology will lead to further development of appropriate control measures.

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“…Furthermore, the increased drug-resistant strains in animals will pollute the inanimate environment (9). Many reports have been concerned with the danger of spread of resistant E. coli strains in the human environment (3,5,12,13,17,18,20,24).…”

Section: (19)mentioning

confidence: 99%

Drug Resistance and Conjugative R Plasmids in Fecal Escherichia coli Strains Isolated from Healthy Younger Animals (Chickens, Piglets, Calves) and Children

Kanai

Hashimoto

Mitsuhashi

1983

Microbiology and Immunology

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A total of 11,777 Escherichia coli strains were isolated from 90 chickens, 103 piglets, 96 calves, and 104 children in 1979 in Gunma Prefecture and tested for drug resistance and the presence of conjugative R plasmids, The percentages of individuals that excreted drug-resistant strains were: chickens, 100%; piglets, 99%; calves, 100%; and children, 64%. The frequency of isolation of drug-resistant strains among the total isolates was: chickens, 98%; piglets, 93%; calves, 94%; and children, 41 %. Frequency of isolation of R plasmids among the strains tested was: chickens, 48%; piglets, 33%; calves, 38%; and children, 10%.Resistance patterns of the strains isolated most frequently among the four groups were tetracycline (TC), sulfonamides (SA) in single resistance, TC.SA in double resistance, TC.streptomycin (SM) .SA in triple resistance and TC:SM.SA. kanamycin (KM) in quadruple resistance.R plasmids were isolated frequently from animals (over 33%) but infrequently from children (about 10%).The high frequency of isolation of drug-resistant strains and R plasmids from animals was caused by the heavy use of chemicals in the period of growth of younger animals.In the livestock industry in Japan, animals and fowls are fed and reared in small spaces. These crowded rearing conditions are dangerous, because animals are easily infected with bacteria from others. Especially at the younger ages, infections are not infrequent and many kinds of drugs have been used for prevention of infection as well as for therapy of infectious diseases. This situation may cause the appearance and spread of drug-resistant strains, as has been suggested in many reports (1,4,14,16,19,22,23,25).In a previous paper we presented a detailed survey of resistant strains among livestock and adult humans. Examining as many as 30 strains from each individual animal, we hoped to isolate resistant strains that composed a smaller fraction of the total Escherichia coli cells. The calculated incidence of individuals excreting E. coli cells resistant to a drug would be less than that in the case when the selection is made by drug plates. Nevertheless, the value obtained was moder-1031

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Matching of Antibiotic Resistance Patterns of Escherichia coli of Farm Families and Their Animals

Cited by 35 publications

References 7 publications

Direct transmission of Escherichia coli from poultry to humans

Direct transmission of Escherichia coli from poultry to humans

Trends in Human Fecal Carriage of Extended-Spectrum β-Lactamases in the Community: Toward the Globalization of CTX-M

Drug Resistance and Conjugative R Plasmids in Fecal Escherichia coli Strains Isolated from Healthy Younger Animals (Chickens, Piglets, Calves) and Children

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