Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women

Farlay, Delphine; Falgayrac, Guillaume; Ponçon, Camille; Rizzo, Sébastien; Cortet, Bernard; Chapurlat, Roland; Penel, Guillaume; Badoud, Isabelle; Ammann, Patrick; Boivin, Georges

doi:10.1016/j.bonr.2022.101623

Cited by 4 publications

(8 citation statements)

References 70 publications

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“…Although we did not perform indentation and Raman spectroscopy on the same animals, we hypothesize with reasonable confidence that the gradient in mechanical properties we demonstrated through microindentation is in part explained by the observed mineralization gradient in the healthy ATE. This assumption is consistent with a recent study that found, on cortical and trabecular bone, a positive correlation between elastic modulus, hardness, and phosphate-to-collagen ratio using indentation and Raman techniques ( Farlay et al, 2022 ). However, other factors could also explain the ATE micromechanical properties we observed.…”

Section: Discussionsupporting

confidence: 93%

“…Mineralization is known to have an impact on the micromechanical properties of biological tissue ( Farlay et al, 2022 ; Gupta et al, 2005 ; Roseren et al, 2022 ; Zysset, 2009 ). Both elastic modulus and hardness depend on the degree of mineralization of the tissue ( Farlay et al, 2022 ; Gupta et al, 2005 ; Roseren et al, 2022 ; Zysset, 2009 ). Another factor determining bone elastic modulus and hardness is crystallinity corresponding to the size and organization of apatite crystals ( Farlay et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Both elastic modulus and hardness depend on the degree of mineralization of the tissue ( Farlay et al, 2022 ; Gupta et al, 2005 ; Roseren et al, 2022 ; Zysset, 2009 ). Another factor determining bone elastic modulus and hardness is crystallinity corresponding to the size and organization of apatite crystals ( Farlay et al, 2022 ). Crystallinity depends in part on substitutions that occur in the crystal.…”

Section: Discussionmentioning

confidence: 99%

“…However, other factors could also explain the ATE micromechanical properties we observed. In mineralized tissues, it has been suggested and/or demonstrated that elastic modulus and hardness depend on the maturity and orientation of apatite crystals, as well as on the composition, maturity, and organization of collagen fibers, and lastly on the non-collagenous matrix such as proteoglycans ( Farlay et al, 2022 ; Zysset, 2009 ; Gupta et al, 2005 ; Hao et al, 2022 ). These parameters were not investigated in the present study.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading

Camy,

Grünewald,

Lamy

et al. 2024

Bone Reports

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading

Camy,

Grünewald,

Lamy

et al. 2024

Bone Reports

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“…Bone mineral crystallinity is related to the crystal size and crystal quality, and the crystal size can affect the bone tissue material properties [ 33 ]. We found that the mineral crystallinity of femoral neck cortical bone gradually increased while the micro—mechanical properties gradually decreased during the process of bone loss, and there was a significant relationship of them.…”

Section: Discussionmentioning

confidence: 99%

The role of microscopic properties on cortical bone strength of femoral neck

Xia¹,

Cai

Kan

et al. 2023

BMC Musculoskelet Disord

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Background Femoral neck fractures are serious consequence of osteoporosis (OP), numbers of people are working on the micro—mechanisms of femoral neck fractures. This study aims to investigate the role and weight of microscopic properties on femoral neck maximum load (Lmax), funding the indicator which effects Lmax most. Methods A total of 115 patients were recruited from January 2018 to December 2020. Femoral neck samples were collected during the total hip replacement surgery. Femoral neck Lmax, micro—structure, micro—mechanical properties, micro—chemical composition were all measured and analyzed. Multiple linear regression analyses were performed to identify significant factors that affected the femoral neck Lmax. Results The Lmax, cortical bone mineral density (cBMD), cortical bone thickness (Ct. Th), elastic modulus, hardness and collagen cross—linking ratio were all significantly decreased, whereas other parameters were significantly increased during the progression of OP (P < 0.05). In micro—mechanical properties, elastic modulus has the strongest correlation with Lmax (P < 0.05). The cBMD has the strongest association with Lmax in micro—structure (P < 0.05). In micro—chemical composition, crystal size has the strongest correlation with Lmax (P < 0.05). Multiple linear regression analysis showed that elastic modulus was most strongly related to Lmax (β = 0.920, P = 0.000). Conclusions Compared with other parameters, elastic modulus has the greatest influence on Lmax. Evaluation of microscopic parameters on femoral neck cortical bone can clarify the effects of microscopic properties on Lmax, providing a theoretical basis for the femoral neck OP and fragility fractures.

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COMPARISON AND PERFORMANCE OF Α, Α+β AND Β TITANIUM ALLOYS FOR BIOMEDICAL APPLICATIONS

Pesode¹

2023

Surf. Rev. Lett.

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As implant materials, titanium and its alloys have been extensively utilized because of their exceptional mechanical properties and biocompatibility. Despite this, corporations and researchers alike have kept up their aggressive pursuit of better alloys since there are still issues that require immediate attention. One of these causes a problem with stress shielding as a noticeable variation in the elastic modulus of the implant material. Ti alloys release harmful ions after extended usage. The poor bioactivity of the Ti alloy surface slows the healing process. In order to address these problems, additional research has concentrated on developing Ti alloys for the 21st century that contain a more suitable phase and change the surface of the alloy from inherently bioinert to bioactive. This study assesses the knowledge presently existing on the biological, chemical, mechanical, and electrochemical characteristics of important [Formula: see text]-Ti alloys created in recent years with the objective to provide scientific justification for using [Formula: see text]-titanium-based alloys as a substitute for cpTi. Dental implants might be made using [Formula: see text]-Ti alloys as an alternative. The enhanced alloy qualities, which include a lower modulus of elasticity, improved strength, suitable biocompatibility, and good abrasion and excellent resistance to corrosion, offer the essential proof. Additionally, structural, chemical, and thermomechanical modifications to [Formula: see text]-Ti alloys allow for the production of materials that may be tailored to the needs of unique instances for clinical practises. By researching the paper, the performance and attributes of [Formula: see text]-titanium alloy are compared to those of other forms of titanium alloy, such as [Formula: see text] titanium alloys. To support their usage as cpTi substitutes, in vivo studies are required to assess new [Formula: see text]-titanium alloys.

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Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women

Cited by 4 publications

References 70 publications

Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading

Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading

The role of microscopic properties on cortical bone strength of femoral neck

COMPARISON AND PERFORMANCE OF Α, Α+β AND Β TITANIUM ALLOYS FOR BIOMEDICAL APPLICATIONS

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