This paper investigates the root cause of a recurring failure observed in the first-stage blades of an industrial gas turbine. The failure involves the loss of the trailing edge tip of the blades. The study employs a combination of metallographic analysis and computational simulations utilizing the finite element method and computational fluid dynamics. The metallographic analysis reveals significant degradation in the GTD-111 nickel-based superalloy within the region where the failure occurs. This degradation is characterized by the coarsening and coalescence of the gamma prime phase, which can be attributed to localized overheating. Additionally, the computational study enables the calculation of the trajectory, pressure, and temperature profiles of the hot gases, as well as the distribution of temperatures within the blade. These findings demonstrate that the cooling airflow is influenced by the hot gas flow, particularly in the vicinity of the fault location, owing to the orientation of the cooling ducts, which results in overheating in this area. Ultimately, the temperatures derived from the microstructural analysis using the Ostwald-ripening theory align remarkably well with the results obtained from the simulation, validating the accuracy of the computational model. By combining metallographic analysis and computational simulations, this study provides crucial insights into the failure mechanism of the first-stage blades.