Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide

Abstract

This study aims to co-process native Ipomea batatas starch (NPS) with colloidal silicon dioxide and evaluate the properties of the co-processed excipient (CPS). The powder morphology was determined by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-Ray Diffraction (XRD) measurements. The compressional, mechanical and release properties of metronidazole tablet formulations were evaluated. NPS was predominantly oval in shape while CPS had more large truncated ellipsoidal granules. Both NPS and CPS exhibited spectra typical of a Type A XRD pattern, but CPS has a sharp peak with strong intensity at 27 0 2q which was absent in NPS. Although NPS had a faster onset of plastic deformation, the overall amount of plastic deformation was higher in CPS. Tablets formulated with CPS had faster dissolution than those containing similar concentration of NPS. The co-processing of Ipomea batatas starch with colloidal silicon dioxide resulted in modification of its powder and tableting properties.

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

“…The true density was determined by the fluid displacement method using n-hexane as the displacement fluid 15 . The angle of repose was determined by the fixed funnel method while the moisture content of the samples were determined by gravimetric analysis 16 . Hausner's ratio was calculated as the ratio of the tapped density to the bulk density of the samples.…”

“…The percentage carr's compressibility was calculated from the differences between the tapped density and the bulk density divided by the tapped density and the ratio expressed as a percentage. The swelling capacity was obtained by the method of Bakre et al 16 with slight modification.…”

“…The uniformity of weight, friability (FR), crushing strength (CS) and disintegration time (D T ) were determined according to established procedure [15][16][17] . The disintegration efficiency ratio (DER) was calculated as ratio of CSFR to friability.…”

Evaluation of Basella alba L. Mucilage as a Suspending Agent in Metronidazole Suspension

“…The tube was centrifuged at 3000 rpm for 10 minutes and the supernatant was decanted. The weight of the sediment was used in calculating the hydration capacity using equation 2 17,18 : Determinations was done in triplicate…”

Formulation and Evaluation of Sustained Release Ibuprofen Matrix Tablets Using Starch from Maize Genotypes as Polymer

“…Maize starch has been widely employed as diluent, disintegrant and binder in tablet dosage forms. Modification of native starches have been carried out to obtain newer excipients with improved functionality [5][6][7][8]. Starch functionality depends on the starch structure and composition, which vary with genotypes [9].…”