Early November 1597. After an intense combat with four enemy ships, San Giacomo di Galizia (also known as Santiago), a just over 1000-ton galleon, enters the Ribadeo harbour in a terrible state, where it wrecks. This war vessel had been built in Naples in 1590 and sailed the Mediterranean and the Atlantic until it sank. In late November 2011, during an archaeological survey of the dredge area to improve the navigation of the ports in Galicia, a large ship was found and identified as the San Giacomo, which wrecked 414 years prior to its discovery. Several archaeological campaigns permitted a thorough record of the wreck and the recovery of hundreds of objects which this ship carried on its final journey. These artefacts included ceramics, metalwork, and wood, objects which reflected the activities that occurred on board during its short life. Combining an interdisciplinary approach based on artefacts, documents, and chemical analysis, the aim of this paper is to, on the one hand, attempt to reconstruct the sailing itinerary of the ship over its period of use and, on the other, to discuss how these commodities can help to write new narratives about the activities which occurred on board.