The material point method (MPM) enhanced with B-spline basis functions, referred to as B-spline MPM (BSMPM), is developed and demonstrated using representative quasi-static and dynamic example problems. Smooth B-spline basis functions could significantly reduce the cell-crossing error as known for the original MPM. A Gauss quadrature scheme is designed and shown to be able to diminish the quadrature error in the BSMPM analysis of largedeformation problems for the improved accuracy and convergence, especially with the quadratic B-splines. Moreover, the increase in the order of the B-spline basis function is also found to be an effective way to reduce the quadrature error and to improve accuracy and convergence. For plate impact examples, it is demonstrated that the BSMPM outperforms the generalized interpolation material point (GIMP) and convected particle domain interpolation (CPDI) methods in term of the accuracy of representing stress waves. Thus, the BSMPM could become a promising alternative to the MPM, GIMP, and CPDI in solving certain types of transient problems. KEYWORDS B-spline basis functions, Gauss quadrature, large deformation, material point method, mesh refinement, transient problems