Material priority engineered metal-polyphenol networks: mechanism and platform for multifunctionalities

Abstract

Engineering the surface of materials with desired multifunctionalities is an effective way to fight against multiple adverse factors during tissue repair process. Recently, metal-polyphenol networks (MPNs) have gained increasing attention because of their rapid and simple deposition process onto various substrates (silicon, quartz, gold and polypropylene sheets, etc.). However, the coating mechanism has not been clarified, and multifunctionalized MPNs remain unexplored. Herein, the flavonoid polyphenol procyanidin (PC) was selected to form PC-MPN coatings with Fe3+, and the effects of different assembly parameters, including pH, molar ratio between PC and Fe3+, and material priority during coating formation, were thoroughly evaluated. We found that the material priority (addition sequence of PC and Fe3+) had a great influence on the thickness of the formed PC-MPNs. Various surface techniques (e.g., ultraviolet–visible spectrophotometry, quartz crystal microbalance, X-ray photoelectron spectroscopy, atomic force microscopy, and scanning electron microscopy) were used to investigate the formation mechanism of PC-MPNs. Then PC-MPNs were further engineered with multifunctionalities (fastening cellular attachment in the early stage, promoting long-term cellular proliferation, antioxidation and antibacterial activity). We believe that these findings could further reveal the coating formation mechanism of MPNs and guide the future design of MPN coatings with multifunctionalities, thereby greatly broadening their application prospects, such as in sensors, environments, drug delivery, and tissue engineering. Graphical Abstract

Facile Universal Strategy of Presenting Multifunctional Short Peptides for Customizing Desired Surfaces

“…Antimicrobial and antifouling functions are often required for medical diagnostic devices and therapeutic tools/implants. 49 Therefore, CM15 sequences, which have antimicrobial properties, 50 and PEG chain segments, which have antifouling properties, 51 were used to modify the surfaces of positively charged peptides (Lys 6 ). Then, peptide coatings were prepared, and their antimicrobial and antifouling properties were investigated.…”

Engineering tunable dual peptide hybrid coatings promote osseointegration of implants

“…Polyphenols possess diverse bioactivities including anti-inflammatory, anticancer, antibacterial, and antioxidant effects [ 26 ]. In recent years, the metal polyphenol networks (MPNs) constructed by the coordination of metal ions and phenolic ligands [ 27 ] have received more and more attention due to its ability to deposit onto on various substrates and particles [ 28 ]. Although MPNs exhibit broad applicability of metal ions and polyphenol species, their capabilities still fall short in providing the functions are required throughout the complex processes of bone defect repair [ 29 ].…”

Curcumin@Fe/Tannic Acid Complex Nanoparticles for Inflammatory Bowel Disease Treatment

“…Metal–polyphenol networks also exhibit adhesion-based encapsulation behavior owing to physicochemical interactions (e.g., cation−π and coordination interactions) between the metal cation and polyphenol . Encapsulating Cur in a Fe 3+ /TA metal–polyphenol network is expected to improve the solubility and drug release behavior of Cur and expand its clinical application. − All the components of the Cur@Fe&TA nanodrug delivery system are pharmacologically active, thereby reducing the use of nontherapeutic excipients. , Moreover, this multidrug nanodrug delivery system is expected to promote the treatment of IBD through synergistic therapeutic effects. , …”