Material properties and biosynthetic activity of articular cartilage from the bovine carpo-metacarpal joint

Lewis, Richard J.; MacFarland, A.K.; Anandavijayan, Sothinathan; Aspden, Richard M.

doi:10.1053/joca.1998.0142

Cited by 18 publications

(17 citation statements)

References 24 publications

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“…In such materials interactions between components play an important role [11]. In a previous study of bovine cartilage, in which we found the site variation of composition over the tibial plateau to be similar to previous reports from other joints, we found no clear relationship between gross composition and modulus measured at slow rates of loading [12].…”

Section: Introductionsupporting

confidence: 73%

The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

Burgin

Edelsten

Aspden

2014

Medical Engineering & Physics

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The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5mJ and velocity 1.25ms(-1). The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves. Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150MPa. These values compared with 1-3MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25% of the variance in modulus.

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Section: Introductionsupporting

confidence: 73%

The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

Burgin

Edelsten

Aspden

2014

Medical Engineering & Physics

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“…Full thickness cylindrical cartilage explants without subchondral bone were extracted from the center of 21 cells (Fig. 1) of the grids using a 4‐mm diameter round‐hole hand punch (McMaster‐Carr, Elmhurst, IL) and a surgical scalpel 17. Explants were not removed from regions of fibrillated cartilage, as identified by an India ink test 18.…”

Section: Methodsmentioning

confidence: 99%

Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate

Deneweth

Newman

Sylvia

et al. 2012

Journal Orthopaedic Research

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Knowledge of the extent to which tibial plateau cartilage displays non-uniform mechanical topography under physiologically relevant loading conditions is critical to evaluating the role of biomechanics in knee osteoarthritis. Cartilage explants from 21 tibial plateau sites of eight non-osteoarthritic female cadaveric knees (age: 41-54; BMI: 14-20) were tested in unconfined compression at 100% strain/s. The elastic tangent modulus at 10% strain (E 10% ) was calculated for each site and averaged over four geographic regions: not covered by meniscus (I); covered by meniscus-anterior (II); covered by meniscus-exterior (III); and covered by meniscus-posterior (IV). A repeated-measures mixed model analysis of variance was used to test for effects of plateau, region, and their interaction on E 10% . Effect sizes were calculated for each region pair. E 10% was significantly different (p < 0.05) for all regional comparisons, except I-II and III-IV. The regional pattern of variation was consistent across individuals. Moderate to strong effect sizes were evident for regional comparisons other than I-II on the lateral side and III-IV on both sides. Healthy tibial cartilage exhibits significant mechanical heterogeneity that manifests in a common regional pattern across individuals. These findings provide a foundation for evaluating the biomechanical mechanisms of knee osteoarthritis. ß

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“…A sinusoidally compressive force between 16 and 36 N was applied using a cylindrical indenter, with a chamfered end to prevent cartilage damage at the edge of the contact area, with a diameter of 5.2 mm. This loading was applied at eight different frequencies (1,8,10,12,29,49, 71 and 88 Hz). This follows recommendations from a previous study, 11 which characterised frequency-dependent viscoelastic properties of healthy bovine articular cartilage between 1 and 90 Hz.…”

Section: Dma Frequency Sweepmentioning

confidence: 99%

“…The assumption being that viscous and elastic properties of cartilage are 'independent', that is, associated solely to fluid and structural components, respectively. However, viscoelastic properties of cartilage are likely a result of interactions between the fibrereinforcing collagen and the surrounding gel, 29 with the mechanism of stress transfer being a key factor in its mechanical behaviour. [30][31][32][33] Thus, the increased loss stiffness with hypo-hydration could be a consequence of increased energy dissipation during the interaction between a more viscous gel (i.e.…”

Section: Overviewmentioning

confidence: 99%

Effect of hydration on the frequency-dependent viscoelastic properties of articular cartilage

Pearson

Espino

2013

Proc Inst Mech Eng H

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The aim of this study was to determine the effect of tissue hydration on the frequency-dependant viscoelastic properties of articular cartilage. Such changes were determined at frequencies associated with normal (1-10 Hz) and impulsive/traumatic (90 Hz) heel-strike times. Cartilage on bone samples, obtained from bovine humeral heads, was tested when hypo-hydrated and hyper-hydrated using dynamic mechanical analysis. Dynamic mechanical analysis was performed at a range of frequencies between 1 and 90 Hz. Hypo-hydration increased the stiffness of cartilage as compared to hyper-hydrated cartilage; this increase was greater at higher frequencies. The storage modulus and stiffness increased in hypo-hydrated cartilage as compared to hyper-hydrated cartilage. However, the loss modulus and stiffness increased when cartilage was hypo-hydrated as compared to hyper-hydrated, but these increases were not frequency dependent. An impulsive heel-strike time may result in a greater increase of stiffness in hypo-hydrated cartilage, compared with hyper-hydrated cartilage. However, the ratio of storage to loss stiffness was greater for hyper-hydrated cartilage, thereby, reducing the tissue's ability to dissipate energy and increasing the likelihood of cartilage rupture.

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Material properties and biosynthetic activity of articular cartilage from the bovine carpo-metacarpal joint

Cited by 18 publications

References 24 publications

The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate

Effect of hydration on the frequency-dependent viscoelastic properties of articular cartilage

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