Materials characterisation and cytotoxic assessment of strontium-substituted bioactive glasses for bone regeneration

O’Donnell, Matthew; Çandarlıoğlu, Pelin L; Miller, C.A; Gentleman, Eileen; Stevens, Martin

doi:10.1039/c0jm01139h

Cited by 112 publications

(108 citation statements)

References 65 publications

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“…On the ball wear scars lubricated by both distilled water and DNP dispersions, the Raman spectra showed no peaks between 1200 and 2000 cm −1 . The peaks at 1070 cm −1 were observed that can be attributed to stretching and bending modes of carbonate in WC ball itself (Berger et al, 2014;Ma & Du, 2008;O'Donnell, Candarlioglu, Miller, Gentleman, & Stevens, 2010). It is summarized from the Raman spectra that DNPs existed in the steel plate surfaces and did not on the WC ball surfaces after the DNP dispersion lubrication.…”

Section: Distilled Watermentioning

confidence: 88%

Tribological properties of diamond nanoparticle additive in water under a lubrication between steel plate and tungsten carbide ball

Alias

Kinoshita

Fujii

2015

JAMDSM

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We studied the effectiveness of diamond nanoparticles (DNPs) dispersed in water as a lubricant additive between stainless steel plates and sintered tungsten carbide (WC) balls. DNP dispersions with concentrations of 0.01, 0.1 and 1 wt.% were prepared and used as lubricants under a load of 1.88 N, for 240,000 friction cycles. High-friction coefficients of more than 0.3 were observed in an initial period. Then friction coefficients declined and stabilised at values of approximately 0.1. The steady-state friction coefficients were independent of the DNP concentration and lower than that for distilled water. In the initial period, wear of both the plates and ball was obvious. In the steady-state period, additional wear on the plates was a little; however, ball wear scars were clearly observed. The size of the ball wear scars decreased with decreasing the DNP concentration. It is likely that DNPs were embedded mainly in the stainless steel plates, and the embedded DNPs protected the plates and wore the balls in the steady-state period. Compared with the lubrication under distilled water, the friction coefficient and wear of the plate under the lubrication by the 0.01 wt.% DNP dispersion were lower, and the wear of the ball by this lubrication condition was not higher.

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Section: Distilled Watermentioning

confidence: 88%

Tribological properties of diamond nanoparticle additive in water under a lubrication between steel plate and tungsten carbide ball

Alias

Kinoshita

Fujii

2015

JAMDSM

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“…Although the mechanism of action of SrRan is not fully understood (6, 7), strontium ions have been reported to be the active component of the drug. Incorporating strontium into biomaterials has been shown to up-regulate osteogenic markers in vitro and osteoconduction in vivo (8)(9)(10)(11)(12); however, how such strontium-doped biomaterials improve clinical outcomes and, importantly, how such biomaterials influence the global response of osteoprogenitor cells are largely unknown.…”

mentioning

confidence: 99%

Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials

Autefage

Gentleman

Littmann

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Despite the increasing sophistication of biomaterials design and functional characterization studies, little is known regarding cells' global response to biomaterials. Here, we combined nontargeted holistic biological and physical science techniques to evaluate how simple strontium ion incorporation within the well-described biomaterial 45S5 bioactive glass (BG) influences the global response of human mesenchymal stem cells. Our objective analyses of whole gene-expression profiles, confirmed by standard molecular biology techniques, revealed that strontium-substituted BG up-regulated the isoprenoid pathway, suggesting an influence on both sterol metabolite synthesis and protein prenylation processes. This upregulation was accompanied by increases in cellular and membrane cholesterol and lipid raft contents as determined by Raman spectroscopy mapping and total internal reflection fluorescence microscopy analyses and by an increase in cellular content of phosphorylated myosin II light chain. Our unexpected findings of this strong metabolic pathway regulation as a response to biomaterial composition highlight the benefits of discovery-driven nonreductionist approaches to gain a deeper understanding of global cellmaterial interactions and suggest alternative research routes for evaluating biomaterials to improve their design.strontium-releasing biomaterials | human mesenchymal stem cells | microarray analysis | sparse feature selection analysis | mevalonate pathway A n important aim of regenerative medicine is to design smart biomaterials to trigger specific biological responses and enable complex tissue repair (1). Standard in vitro and in vivo testing of such materials usually focuses on assessing the anticipated cell response, often stem cell differentiation to a particular lineage and/or appropriate tissue formation. Although this strategy allows the characterization of specific outcomes, the global cell responses to most biomaterials remain relatively unknown and their mechanisms of action largely unidentified. In comparison with this standard approach, the pharmacology and molecular biology communities have revolutionized their respective fields by taking advantage of unsupervised "-omic" technologies that allow the global biological response to be examined without the inherent bias introduced by predicting particular outcomes. The adoption of comparable hypothesis-generating holistic approaches in the biomaterials communities could stimulate a similar paradigm shift, allowing prospective, rational material design instead of retrospective material evaluation.With more than 2.2 million bone-grafting procedures carried out annually worldwide, the market for smart biomaterials that can be used as functional alternatives to current autogenic and allogenic grafts is significant (2). One biomaterial-based regenerative approach involves the incorporation of biologically active moieties into biomaterials to enhance their bone regeneration properties (3). Strontium ranelate (SrRan) reduces vertebral and nonvertebral fr...

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“…Many glass compositions have been developed by doping therapeutically active ions such as strontium, zinc, magnesium, fluoride and cobalt in silicate glass system have been discovered in the past [6][7][8][9] . Several researches are going on for preparation and characterization of glasses and glass-ceramics, doped with some ions such as Zr, Li, Fe, Ti, K, Zn, Sr and Mg because of their unique effect on differentiation, osteoblastic cell proliferation and thus bone mineralization [10][11][12][13][14][15] . The ZrO 2 substituted is widely used as a substrate in hard tissue applications due to its excellent strength and fracture toughness 16 .…”

Section: Introductionmentioning

confidence: 99%

Development of Zirconia Substituted 1393 Bioactive Glass for Orthopaedic Application

Yadav¹,

Ray²,

Ershad³

et al. 2017

Orient. J. Chem

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Zirconia was used as a bone substitute, since it has excellent mechanical properties. It is also good bioinert to bone tissue. In this study, we report on zirconia substituted 1393 bioactive glass. In novel melt-derived "1393" Bioactive glass (53 SiO 2 , 6Na 2 O, 12 K 2 O, 5MgO, 20CaO, and 4 P 2 O 5 wt %) with CaO was doped by ZrO 2 for and were melted at 1400°C in alumina crucibles in electric furnace with air as furnace atmosphere. Bioactivity of these samples were analysed by put in the SBF for different time periods. Hydroxy Carbonate Apatite layer was developed and identiûed by FTIR, XRD and SEM. Chemical durability was also determined by weight loss method. Density of the samples were determined and found to increase significantly with increasing amount of (0-2 wt %) zirconia, reason is due to replacement of lighter element of CaO has been replaced by heavier element ZrO 2. Finally, this investigation clearly concluded that ZrO 2 substituted bioactive glass would be potential biomaterials for biomedical applications.

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Materials characterisation and cytotoxic assessment of strontium-substituted bioactive glasses for bone regeneration

Cited by 112 publications

References 65 publications

Tribological properties of diamond nanoparticle additive in water under a lubrication between steel plate and tungsten carbide ball

Tribological properties of diamond nanoparticle additive in water under a lubrication between steel plate and tungsten carbide ball

Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials

Development of Zirconia Substituted 1393 Bioactive Glass for Orthopaedic Application

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