A key national energy priority to promote energy security is sustainable nuclear power. Nuclear energy currently contributes approximately 20% of baseload electrical needs in the United States and is considered a reliable generation source to meet future electricity needs. Advanced small modular reactors (AdvSMRs) using non-light-water reactor coolants such as liquid metal, helium, or liquid salt are promising mid-to long-term options being explored for added functionality and affordability in future reliable nuclear power deployment. AdvSMRs can offer potential advantages over more conventional technologies in the areas of safety and reliability, sustainability, affordability, functionality, and proliferation resistance. However, a number of technical challenges will need to be addressed before AdvSMRs are ready for deployment, given their potential for remote deployment with minimal staffing, longer operating cycles between planned refueling and maintenance outages, and support for multiple energy applications. In addition, AdvSMRs (like SMRs based on more conventional light-water reactor technologies) will have reduced economy-of-scale savings when compared to current generation lightwater reactors (LWRs). Issues related to AdvSMR deployment can be addressed through cross-cutting RD&D involving instrumentation, controls, and human-machine interface (ICHMI) technologies. Specifically, diagnostics and prognostics technologies provide a mechanism for improving safety and reliability of AdvSMRs through integrated health management of passive components. This report identifies activities and develops an outline of a research plan to address the high-priority technical needs for demonstrating prototypic prognostic techniques to manage degradation of passive AdvSMR components. Concepts for AdvSMRs span a wide range of design maturity, specificity, and concepts of operation, including multi-unit, multi-product-stream generating stations. Key to the development and deployment of AdvSMRs will be the ability to ensure safe and affordable operation of these reactor designs. AdvSMR designs generally place more emphasis on passive systems to assure safety. However, degradation in all passive components will need to be well-managed to maximize safety, operational lifetimes, and plant reliability while minimizing maintenance demands, if reduced economies-of-scale are to be overcome. Traditional approaches such as periodic in-service nondestructive inspections are likely to have limited applicability to AdvSMRs, given the expectation of longer operating periods and potential difficulties with inspection access to critical components. Advanced instrumentation and control (I&C) technologies can provide a mechanism for achieving these goals. However, the significant technology and environmental differences between AdvSMRs and conventional LWRs and the potential for modularized deployment result in unique challenges and needs for advanced ICHMI applications in AdvSMRs. v prognostics is also documented. This assessment, combined wi...