Materials directed to implants for repairing Central Nervous System

Canillas, María; Moreno, B.; Chinarro, E.

doi:10.3989/cyv.302014

Cited by 1 publication

(1 citation statement)

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“…Ceramic materials have been investigated for these applications for decades [9]. These bioceramics may be bioresorbable such as tricalcium phosphate (TCP) or bioactive such as hydroxyapatite (HA), bioactive glasses and glass-ceramics [10][11][12][13][14]. In addition calcium silicates, such as wollastonite (W), are characterized by their excellent osteoinductive properties and rapid bioresorption characteristics [15,16].…”

Section: Introductionmentioning

confidence: 99%

Photopolymerization for filling porous ceramic matrix: Improvement of mechanical properties and drug delivering behavior

et al. 2018

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This work presents the photopolymerisation of composite scaffolds where a prefabricated ceramic scaffold was impregnated with poly(ethylene) glycol dimethacrylate (PEGDMA) macromonomer solution. The PEGDMA solution penetrates the porosity of ceramic scaffold where it cures in situ thereby enhancing their mechanical properties. The mechanical properties of the obtained composite approximate the mechanical properties of cancellous bone. The Young´s Modulus of the composite developed is 106 ± 5 MPa. PEGDMA is a polymer that shows excellent percentages of gel fraction (96%), which preserves when ceramic scaffold is introduced, and swelling (134%). Furthermore, thanks to their swelling properties, the composite is able to control the release vancomycin and dexamethasone. The efficacy of in situ delivery of vancomycin is demonstrated by the inhibition of bacteria colony proliferation. Dexamethasone released is recorded for up to 10 days using ultra violet‐visible spectroscopy. These excellent results make photopolymerization and PEGDMA strong candidates for the manufacture of different loaded bone void fillers. POLYM. COMPOS., 40:1654–1662, 2019. © 2018 Society of Plastics Engineers

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