Materials for absorbable and nonabsorbable surgical sutures

Chu, Chih‐Chang

doi:10.1533/9780857095602.2.275

Cited by 42 publications

(42 citation statements)

References 64 publications

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“…The ratio between glycolide and L-lactide of the PGLA copolymer will determine both, the crystallinity and the rate of absorption. Sutures fabricated from 100% glycolide have the fastest in vivo absorption, while sutures fabricated from 100% L-lactide have the longest absorption times (longer than 5 years to completely absorb) ( Table 5) [79]. For wound closure applications PGA sutures must have enough crystallinity to attain adequate tensile strength required for the application, it must also retain sufficient strength during its degradation and absorption into the body [79,80].…”

Section: Biodegradation and Biocompatibilitymentioning

confidence: 99%

Recycling of Bioplastics: Routes and Benefits

2020

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Continual reduction of landfill space along with rising CO 2 levels and environmental pollution, are global issues that will only grow with time if not correctly addressed. The lack of proper waste management infrastructure means gloablly commodity plastics are disposed of incorrectly, leading to both an economical loss and environmental destruction. The bioaccumulation of plastics and microplastics can already be seen in marine ecosystems causing a negative impact on all organisms that live there, ultimately microplastics will bioaccumulate in humans. The opportunity exists to replace the majority of petroleum derived plastics with bioplastics (bio-based, biodegradable or both). This, in conjunction with mechanical and chemical recycling is a renewable and sustainable solution that would help mitigate climate change. This review covers the most promising biopolymers PLA, PGA, PHA and bio-versions of conventional petro-plastics bio-PET, bio-PE. The most optimal recycling routes after reuse and mechanical recycling are: alcoholysis, biodegradation, biological recycling, glycolysis and pyrolysis respectively.

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Section: Biodegradation and Biocompatibilitymentioning

confidence: 99%

Recycling of Bioplastics: Routes and Benefits

2020

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“…PGA has an orthorhombic unit cell with dimensions of a = 5.22Å, b = 6.19Å, and c(fiber axis) = 7.02Å. The high melting point of PGA is attributed to the stabilized crystal lattice that results from the tight molecular packing and proximity of the ester groups [81]. PGA has specific gravities of 1.707 for a perfect crystal and 1.05 for an amorphous material [56,82].…”

Section: Polyglycolidementioning

confidence: 99%

Polymeric Biomaterials for Scaffold-Based Bone Regenerative Engineering

Ogueri

Jafari

Ivirico

et al. 2018

Regen. Eng. Transl. Med.

114

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Reconstruction of large bone defects resulting from trauma, neoplasm, or infection is a challenging problem in reconstructive surgery. The need for bone grafting has been increasing steadily partly because of our enhanced capability to salvage limbs after major bone loss. Engineered bone graft substitutes can have advantages such as lack of antigenicity, high availability, and varying properties depending on the applications chosen for use. These favorable attributes have contributed to the rise of scaffold-based polymeric tissue regeneration. Critical components in the scaffold-based polymeric regenerative engineering approach often include 1. The existence of biodegradable polymeric porous structures with properties selected to promote tissue regeneration and while providing appropriate mechanical support during tissue regeneration. 2. Cellular populations that can influence and enhance regeneration. 3. The use of growth and morphogenetic factors which can influence cellular migration, differentiation and tissue regeneration in vivo. Biodegradable polymers constitute an attractive class of biomaterials for the development of scaffolds due to their flexibility in chemistry and their ability to produce biocompatible degradation products. This paper presents an overview of polymeric scaffold-based bone tissue regeneration and reviews approaches as well as the particular roles of biodegradable polymers currently in use.

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“…The mechanical and physicochemical properties of PLGA are strongly determined by the ratio of the monomers. Most commercial PLGA grades currently available contain mainly lactide (between 50 and 95 mol %) 7 , 8 with the exception of the absorbable suture material brand Vicryl (90% glycolide) from Ethicon. 9 Copolymers with between 50 and 85 mol % lactide exhibit a tensile strength ( σ u between 41.4 and 55.2 MPa and a tensile modulus ( E ) between 1 and 4.3 GPa.…”

Section: Introductionmentioning

confidence: 99%

PLGA Barrier Materials from CO₂. The influence of Lactide Co-monomer on Glycolic Acid Polyesters

Valderrama

Putten

Gruter

2020

ACS Appl. Polym. Mater.

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The combination of the predicted polymer market growth and the emergence of renewable feedstocks creates a fantastic opportunity for sustainable polymers. To replace fossil-based feedstock, there are only three alternative sustainable carbon sources: biomass, CO 2 , and existing plastics (via mechanical and/or chemical recycling). The ultimate circular feedstock would be CO 2 : it can be electrochemically reduced to formic acid derivatives that subsequently can be converted into useful monomers such as glycolic acid. This work is part of the European Horizon 2020 project “Ocean” in which the steps from CO 2 to glycolic acid are developed. Polyglycolic acid (PGA) and poly(lactide- co -glycolide) (PLGA) copolyesters with high lactic acid (LA) content are well-known. PGA is very difficult to handle due to its high crystallinity. On the other hand, PLGAs with high LA content lack good oxygen and moisture barriers. The aim of this work is to understand the structure–property relationships for the mostly unexplored glycolic acid rich PLGA copolymer series and to assess their suitability as barrier materials. Thus, PLGA copolymers with between 50 and 91 mol % glycolic acid were synthesized and their properties were evaluated. Increased thermal stability was observed with increasing glycolic acid content. Only those containing 87 and 91 mol % glycolic acid were semicrystalline. A crystallization study under non-isothermal conditions revealed that copolymerization reduces the crystallization rate for PLGA compared to polylactic acid (PLA) and PGA. While PGA homopolymer crystallizes completely when cooled at 10 °C·min –1 , the copolymers with 9 and 13% lactic acid show almost 10 times slower crystallization, which is a huge advantage vis-à-vis PGA for processing. The kinetics of this process, modeled with the Jeziorny-modified Avrami method, confirmed those observations. Barrier property assessment revealed great potential for these copolymers for application in barrier films. Increasing glycolic acid content in PLGA copolymers enhances the barrier to both oxygen and water vapor. At room temperature and a relative humidity below 70% the PLGA copolymers with high glycolic acid content outperform the barrier properties of polyethylene terephthalate.

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Materials for absorbable and nonabsorbable surgical sutures

Cited by 42 publications

References 64 publications

Recycling of Bioplastics: Routes and Benefits

Recycling of Bioplastics: Routes and Benefits

Polymeric Biomaterials for Scaffold-Based Bone Regenerative Engineering

PLGA Barrier Materials from CO₂. The influence of Lactide Co-monomer on Glycolic Acid Polyesters

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Materials for absorbable and nonabsorbable surgical sutures

Cited by 42 publications

References 64 publications

Recycling of Bioplastics: Routes and Benefits

Recycling of Bioplastics: Routes and Benefits

Polymeric Biomaterials for Scaffold-Based Bone Regenerative Engineering

PLGA Barrier Materials from CO2. The influence of Lactide Co-monomer on Glycolic Acid Polyesters

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Product

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PLGA Barrier Materials from CO₂. The influence of Lactide Co-monomer on Glycolic Acid Polyesters