Materials Strategies to Overcome the Foreign Body Response

Abstract

The foreign body response (FBR) is an immune‐mediated reaction that can occur with most biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of implantable devices, representing a longstanding challenge that has consistently hampered their optimal utilization. Over the last decade, significant strides have been achieved based on either hydrogel design or surface modifications to mitigate the FBR. This review delves into recent material strategies aimed at mitigating the FBR. Furthermore, we look forward to future novel anti‐FBR materials from the perspective of clinical translation needs. Such prospective materials hold the potential to attenuate local immune responses, thereby significantly enhancing the overall performance of implantable devices.This article is protected by copyright. All rights reserved

Dapansutrile OLT1177 suppresses foreign body response inflammation while preserving vascularisation of implanted materials

“…1 Given that the FBR is primarily driven by inflammation, halting its progression is largely accomplished using antiinflammatory approaches which can involve optimizing both the physical and chemical properties of the material and/or utilizing drugs to reduce immune cell interaction at the tissue-implant interface and minimize the degree of fibrotic encapsulation. 2,3 While these methods effectively suppress fibrosis by antagonising the major pathways of inflammation, this also inactivates other beneficial aspects of immune signalling, such as those that drive tissue healing and associated processes like vascularization. 4 This poses a particular challenge for implants whose functions specifically rely not only on reduced fibrosis but also simultaneously require enhanced vascularisation, such as biosensors, insulin pumps, or cell encapsulation devices.…”