Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan

Ahmed, Mohamed A.; Shareef, Osama; Adam, Ishag

doi:10.12688/f1000research.7386.1

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…However, these findings did not match with previous studies that did not found a significant association between maternal age and the oocyte fertilization rate. 36 On the other hand, the present study observed a significant increase in the status of global DNA methylation among the different age groups where the highest level of global DNA methylation (7.43 ng/μl) has been found in the age group >35 years. A positive association has been found between the status of global DNA methylation and maternal age.…”

Section: Discussioncontrasting

confidence: 53%

Influence of maternal age on intracytoplasmic sperm injection outcome and global deoxyribonucleic acid methylation in women undergoing intracytoplasmic sperm injection cycle

Laqqan

Yassin

2021

Int J Reprod Contracept Obstet Gynecol

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Background: Intracytoplasmic sperm injection needs sufficient oocytes of high quality in order to increase the rate of fertilization and pregnancy. This study was designed to investigate the influence of maternal age on the ICSI outcomes in women undergoing to first ICSI cycle and to evaluate the influence of maternal age on global DNA methylation.Methods: A total of 242 females were included in this study with a mean age of 30.5±7.3 years. The participants were divided into three groups depending on women's age≤25, N=70; 26-35, N=102 and>35, N=70). The genomic DNA was isolated from the blood samples, then the global DNA methylation was evaluated using ELISA.Results: A significant reduction has been found in the level of anti-Müllerian hormone (AMH), total number of the collected oocyte, mature oocytes, fertilized oocytes and number of embryos transferred in the older females compared to the younger group (p<0.001). While a significant increase has been found in global DNA methylation level in the older females compared to the younger group (p<0.001). A positive significant correlation has been found between global DNA methylation level and maternal age (p<0.001). In contrast, a negative significant correlation has been shown between AMH level, mature oocytes and maternal age (p<0.001).Conclusions: Maternal age has a significant influence on the number of mature oocytes, number of embryos transferred and global DNA methylation. The pregnancy chance is more in the age group less than 35 years.

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Section: Discussioncontrasting

confidence: 53%

Influence of maternal age on intracytoplasmic sperm injection outcome and global deoxyribonucleic acid methylation in women undergoing intracytoplasmic sperm injection cycle

Laqqan

Yassin

2021

Int J Reprod Contracept Obstet Gynecol

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“…Some results were consistent with our findings (16) . Other authors reported that the outcome of IVF (retrieved oocytes number) was highest in women aged less than 30 years with poor quality embryo and lower percentage of pregnancy were observed in older women (11,15,(17)(18)(19) . However, some reports, which exhibited, that there is no correlation between maternal age and pregnancy rate are still present (20) .…”

Section: Discussionmentioning

confidence: 98%

The Impact of Maternal Age on Intracytoplasmic Sperm Injection (ICSI) Outcomes in Infertile Couples

2020

MLU

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Objective:The aim of the study is to investigate the impact of maternal age on ICSI outcomes represented by the number of retrieved oocytes, number of fertilized oocytes, embryo quality and pregnancy rate in infertile couples undergoing ICSI. Patients and Method:The study included sixty two infertile couples who underwent ICSI cycles. They divided in to two groups depending on females' age: group Ι with age less than 35 years and group ΙΙ with age more than 35 years. Assessment of ICSI outcomes in form of retrieved oocytes number, fertilized oocytes number, quality of embryo and rate of pregnancy were done and the results were compared between both groups. Results:The study showed that females whom their age more than 35 years produced significantly lower oocytes number with a lower fertilized oocytes when compared with females younger than 35 years. (the mean total number of retrieved oocytes 3.24±0.52 vs 10.84±0.81 and the mean total number of fertilized oocytes 2.29±0.26 vs 7.62±0.52, p-value =0.002 and 0.02 respectively. The total number of good quality embryos was significantly less in the females older than 35 years 1.12±0.18 vs 6.80±0.46, p-value=0.003 and the total number of bad quality embryos was significantly more 1.47±0.24 vs 0.60±0.1, p-value=0.02 when compared with females younger than 35 years. Pregnancy rate was significantly less in the older females p-value=0.0005. Conclusion:The maternal age is one of the most important predictor of ICSI outcomes. An advanced females age has a negative impact on ICSI outcomes and females older than 35 years usually produced lower number of oocytes during oocytes' retrieval with a lower fertilization rate. Embryos produces from those females usually of bad quality and exhibited a lower implantation potential.

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“…These contradictory views on the pattern of thyroid function in PCOS prompted us to conduct the present study, which aimed to evaluate thyroid function and hormonal profile in patients with PCOS. We have previously shown that PCOS was the main cause of female infertility in Sudan [1112]. …”

Section: Introductionmentioning

confidence: 99%

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

et al. 2017

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ObjectiveTo evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS).MethodsA case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, and free thyroxine), anti-thyroid peroxidase, and anti-thyroglobulin antibodies were measured.ResultsWhile there were no significant differences in the age and haemoglobin levels of the two studied groups (55 women in each arm), body mass index was significantly higher in women with PCOS. There were no significant differences in the levels of thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone, luteinizing hormone/follicle stimulating hormone, anti-thyroid peroxidase, anti-thyroglobulin antibodies, cholesterol, triglycerides and low-density lipoprotein cholesterol between the cases and the controls. The mean±standard deviation of free tri-iodothyronine (3.50±0.2 vs. 3.38±0.3 pg/mL, P=0.040) and median (interquartile) high-density lipoprotein cholesterol (37.0 [34.0 to 42.0] vs. 35.80 [29.0 to 41.0] mg/dL, P=0.015) were significantly higher in PCOS patients compared with the control group. In linear regression, PCOS (0.151 pg/mL, P=0.023) and anti-thyroid peroxidase levels (-0.078 pg/mL, P=0.031) were significantly associated with free tri-iodothyronine.ConclusionFree tri-iodothyronine was a significantly higher among PCOS patients compared with the control group.

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Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan

Cited by 7 publications

References 22 publications

Influence of maternal age on intracytoplasmic sperm injection outcome and global deoxyribonucleic acid methylation in women undergoing intracytoplasmic sperm injection cycle

Influence of maternal age on intracytoplasmic sperm injection outcome and global deoxyribonucleic acid methylation in women undergoing intracytoplasmic sperm injection cycle

The Impact of Maternal Age on Intracytoplasmic Sperm Injection (ICSI) Outcomes in Infertile Couples

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

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