Maternal age and offspring health and health behaviours in late adolescence in Sweden

Barclay, Kieron J.; Myrskylä, Mikko

doi:10.1016/j.ssmph.2016.02.012

Cited by 25 publications

(24 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Epidemiological and demographic studies in humans have shown a negative correlation between maternal age and children’s lifespan and health 25,27,30,45,46 . However, maternal age effects in humans can be difficult to separate from confounding environmental factors including paternal age effects, parental health, parental socio-economic status, and parental care 47-49 .…”

Section: Introductionmentioning

confidence: 99%

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Bock

Jarvis

Corey³

et al. 2019

Preprint

View full text Add to dashboard Cite

18Maternal age has a negative effect on offspring lifespan in a range of taxa and is hypothesized 19 to influence the evolution of aging. However, the mechanisms of maternal age effects are 20 unknown, and it remains unclear if maternal age alters offspring response to therapeutic 21 interventions to aging. Here, we evaluate maternal age effects on offspring lifespan, 22 reproduction, and the response to caloric restriction, and investigate maternal investment as a 23 source of maternal age effects using the rotifer, Brachionus manjavacas, an aquatic invertebrate. 24 We found that offspring lifespan and fecundity decline with increasing maternal age. Caloric 25 restriction increases lifespan in all offspring, but the magnitude of lifespan extension is greater in 26 the offspring from older mothers. The trade-off between reproduction and lifespan extension 27 under low food conditions expected by life history theory is observed in young-mother offspring, 28 but not in old-mother offspring. Age-related changes in maternal resource allocation to 29 reproduction do not drive changes in offspring fitness or plasticity under caloric restriction in B. 30 manjavacas. Our results suggest that the declines in reproduction in old-mother offspring negate 31 the evolutionary fitness benefits of lifespan extension under caloric restriction. 32 33 KEYWORDS 34 Maternal effects; aging; caloric restriction; evolutionary fitness; maternal investment 35 36 37 38Maternal effects occur when the environment or physiological state of a mother changes the 39 phenotype of her offspring without a corresponding change in genotype. Offspring phenotype 40 may be modified in response to maternal environmental factors including diet, temperature, or 41 exposure to stressors [1][2][3][4][5][6][7][8][9][10][11] . Such maternal effects may be adaptive as in Daphnia and rotifers, in 42 which offspring hatch with protective spines upon maternal exposure to predators [2][3][4][5][6]12 , or as in 43 plants, in which offspring have higher rates of germination and survival when planted in the 44 same high-light or low-light environment as their parent 7,8 . Alternatively, maternal effects may 45 be detrimental as is the case in the negative health outcomes for children due to excessive 46 maternal smoking or alcohol consumption during pregnancy [13][14][15] . We are beginning to 47 understand that maternal effects may be mediated by a variety of epigenetic mechanisms, 48 including direct transmission of maternal proteins, mRNA, lncRNA, miRNA, and modifications to 49 DNA and histones [16][17][18][19][20] . While maternal effects have long been studied and are well known in 50 the ecological literature, there has been a recent rise in interest in maternal effects in the context 51 of human health and aging 21 . 53Maternal age, or the age of a mother at the time her offspring are born, has been shown to have 54 a negative effect on offspring health in a range of taxa [22][23][24][25][26][27][28][29][30][31][32] . A decrea...

show abstract

Section: Introductionmentioning

confidence: 99%

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Bock

Jarvis

Corey³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Bock

Jarvis

Corey

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Maternal age has a negative effect on offspring lifespan in a range of taxa and is hypothesized to influence the evolution of aging. However, the mechanisms of maternal age effects are unknown, and it remains unclear if maternal age alters offspring response to therapeutic interventions to aging. Here, we evaluate maternal age effects on offspring lifespan, reproduction, and the response to caloric restriction, and investigate maternal investment as a source of maternal age effects using the rotifer, Brachionus manjavacas , an aquatic invertebrate. We found that offspring lifespan and fecundity decline with increasing maternal age. Caloric restriction increases lifespan in all offspring, but the magnitude of lifespan extension is greater in the offspring from older mothers. The trade-off between reproduction and lifespan extension under low food conditions expected by life history theory is observed in young-mother offspring, but not in old-mother offspring. Age-related changes in maternal resource allocation to reproduction do not drive changes in offspring fitness or plasticity under caloric restriction in B. manjavacas . Our results suggest that the declines in reproduction in old-mother offspring negate the evolutionary fitness benefits of lifespan extension under caloric restriction.

show abstract

“…Female reproductive behaviours, including age at first birth (AFB), age at first sexual intercourse (AFS), age at menarche (AMC), age at menopause (AMP) and number of live births (NLB) have important implications in reproductive health and evolutionary fitness 1,2 . Some of these traits have been shown to associate with the physical and mental health of offspring 3 , and there has been growing evidence that maternal AFB is associated with increased risk of psychiatric disorder 4,5 and behavioural problems in their children 6,7 . For instance, both early and late maternal AFB are associated with an increased risk to schizophrenia (SCZ) 4 , bipolar disorder (BIP) 8 , attention-deficit/hyperactivity disorder (ADHD) 7 , autism spectrum disorder (ASD) 9 and depression 10 in offspring.…”

Section: Introductionmentioning

confidence: 99%

The genetic relationship between female reproductive traits and six psychiatric disorders

Amare

Zhou

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Female reproductive behaviours have important implications for evolutionary fitness and health of offspring. Here we used the second release of UK Biobank data (N = 220,685) to evaluate the association between five female reproductive traits and polygenic risk scores (PRS) projected from genome-wide association study summary statistics of six psychiatric disorders (N = 429,178). We found that the PRS of attention-deficit/hyperactivity disorder (ADHD) were strongly associated with age at first birth (AFB) (genetic correlation of −0.68 ± 0.03), age at first sexual intercourse (AFS) (−0.56 ± 0.03), number of live births (NLB) (0.36 ± 0.04) and age at menopause (−0.27 ± 0.04). There were also robustly significant associations between the PRS of eating disorder (ED) and AFB (0.35 ± 0.06), ED and AFS (0.19 ± 0.06), major depressive disorder (MDD) and AFB (−0.27 ± 0.07), MDD and AFS (−0.27 ± 0.03) and schizophrenia and AFS (−0.10 ± 0.03). These associations were mostly explained by pleiotropic effects and there was little evidence of causal relationships. Our findings can potentially help improve reproductive health in women, hence better child outcomes. Our findings also lend partial support to the evolutionary hypothesis that causal mutations underlying psychiatric disorders have positive effects on reproductive success.

show abstract

Maternal age and offspring health and health behaviours in late adolescence in Sweden

Cited by 25 publications

References 45 publications

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

The genetic relationship between female reproductive traits and six psychiatric disorders

Contact Info

Product

Resources

About