Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study

Londero, Ambrogio P.; Rossetti, Emma; Pittini, Carla; Cagnacci, Angelo; Driul, Lorenza

doi:10.1186/s12884-019-2400-x

Cited by 181 publications

(178 citation statements)

References 53 publications

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“…But no research provided the threshold maternal age on BW was 34 years old [12,20,21]. We observed a marginal signi cantly negative association between maternal age and birth weight when maternal age ranged from35 to 40years, which was consistent with the ndings of the previous studies [22,23].…”

Section: Discussionsupporting

confidence: 91%

Changing trends of birth weight with maternal age: a cross-sectional study in Xi'an city of Northwestern China

Wang

Yang

Shang

et al. 2020

Preprint

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Background: Most studies have shown that maternal age is associated with birth weight. However, the specific relationship between each additional year of maternal age and birth weight remains unclear. The study aimed to analyze the specific association between maternal age and birth weight. Methods: Raw data for all live births from 2015 to 2018 were obtained from the Medical Birth Registry of Xi’an, China. A total of 490143 mother-child pairs with full-term singleton live births and the maternal age ranging from 20 to 40 years old were included in our study. Birth weight, gestational age, birth date of the newborns, maternal birth date, residence and ethnicity were collected. Generalized additive model and two-piece wise linear regression model were used to analyze the specific relationships between maternal age and birth weight, risk of low birth weight, and risk of macrosomia. Results: The relationships between maternal age and birth weight, risk of low birth weight, and risk of macrosomia were nonlinear. Birth weight increased 16.204 g per year when maternal age is less than 24 years old (95%CI: 14.323, 18.086), and increased 12.051g per year when maternal age ranged from 24 to 34 years old (95%CI: 11.609, 12.493), then decreased 0.824g per year (95% CI: -3.112, 1.464). The risk of low birth weight decreased with the increase of maternal age until 36 years old (OR= 0.917, 95%CI: 0.903, 0.932 when maternal age younger than 27 years old; OR= 0.965, 95%CI: 0.955, 0.976 when maternal age ranging from 27 to 36 years old), then increased when maternal age older than 36 years old (OR=1.133, 95%CI: 1.026, 1.250). The risk of macrosomia increased with the increase of maternal age (OR=1.102, 95%CI: 1.075, 1.129 when maternal age younger than 24 years old; OR=1.065, 95%CI: 1.060, 1.071 when maternal age ranged from 24 to 33 years old; OR=1.029, 95%CI: 1.012, 1.046 when maternal age older than 33 years old). Conclusions: For women of childbearing age (20-40 years old), the threshold of maternal age on low birth weight was 36 years old, and the risk of macrosomia increased with the increase of maternal age.

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Section: Discussionsupporting

confidence: 91%

Changing trends of birth weight with maternal age: a cross-sectional study in Xi'an city of Northwestern China

Wang

Yang

Shang

et al. 2020

Preprint

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“…A number of factors before and during pregnancy may affect the events of APO, including maternal age [20], smoking, excessive drinking [21,22], overweight or obesity, metabolic disorders (such as diabetes) [23,24], and some chronic diseases such as chronic kidney disease [25], systemic lupus erythematosus [26], cardiovascular diseases [27], and so on. The results indicated that pregnant women with APO were characterized by higher Hcy, TC, TG, LDL-C, FPG, age, SBP, DBP, and BMI, and lower folate, VB12, and HDL-C concentrations, compared with controls (P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

Liu

Luo

Wang

et al. 2020

BMC Pregnancy Childbirth

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Background: Hyperhomocysteinemia may be a risk factor for endothelial dysfunction. Folate and vitamin B12 regulate the homocysteine metabolic process. This study aimed to evaluate the associations between subsequent events of adverse pregnancy outcome and early variables of homocysteine, folate, and vitamin B12 in pregnant women. Methods: This multicenter, retrospective, case-control study involved 563 pregnant women with adverse pregnancy outcome and 600 controls. Adverse pregnancy outcomes included one or more of the following events: preeclampsia, preterm birth, low birth weight, and stillbirth. The associations between subsequent events of adverse pregnancy outcome and early variables of homocysteine, folate, and vitamin B12; metabolic parameters; inflammatory markers; anthropometrics; and lifestyle habits at 11-12 weeks of gestation were analyzed using the logistic regression model. Results: Compared to the lower quartile homocysteine concentrations, the upper quartile homocysteine concentrations were associated with preeclampsia, preterm birth and low birth weight. On the contrary, the lower quartile folate concentrations were associated with preeclampsia, preterm birth and low birth weight compared with the upper quartile folate concentrations. The incidence of adverse pregnancy outcome increased progressively from the first to fourth homocysteine quartiles but decreased progressively from the first to fourth folate quartiles. After adjusting for confounding factors, multivariate logistic regression analysis showed that besides systolic blood pressure, diastolic blood pressure, body mass index and age, homocysteine (IV vs I quartile, aOR 5.89, 95% CI 4.08-8.51, P < 0.001), folate (IV vs I quartile, aOR 0.35, 95% CI 0.25-0.50, P < 0.001), folate supplementation (yes vs no, aOR 0.55, 95% CI 0.35-0.86, P = 0.010) during early pregnancy were independently associated with subsequent events of adverse pregnancy outcome, and vitamin B12 was rejected. Of these, the homocysteine revealed the highest odds ratio in all risk variables, and folate showed the lowest odds ratio in all protective variables.

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“…Many studies have reported the association between maternal age and preterm birth; both extreme ages either under 18 years or above 40 years are considered to be risk factors for preterm birth 26 , 27 , 28 , 29 . Though the majority of the studies concluded that the older maternal age was associated with higher risk of preterm birth, Ambrogio and colleagues in their study observed that both extreme ages that is, maternal age under 17 and advanced age over 40 were independent factors for preterm birth (OR 2.97; 95%CI 1.24, 7.14 , P<0.005) 26 . This was echoed by Florent and co-authors who also found that both advanced age and lower age were risk factors for preterm birth 28 .…”

Section: Discussionmentioning

confidence: 93%

Assessing the association between periodontitis and preterm birth : A case control study

Uwambaye

Munyanshongore

Rulisa

et al. 2020

Preprint

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Background: Premature delivery is among the leading causes of perinatal mortality and morbidity in developed societies which is an important problem in obstetrics. Maternal periodontitis is a prevalent condition that has been suspected to be associated with adverse pregnancy outcomes such as preterm birth. However, there are still conflicting results which this study aims to address by examining the association between periodontitis and preterm birth. This study provides necessary information to inform decisions on the screening tool to be recommended for use by nurses and midwives to screen for periodontal diseases during antenatal consultations in order to improve mothers’ and children’s health. Methods: A case control study was conducted at 12 health facilities in the Southern Province of Rwanda from February to August 2018. A total of 555 women in the postpartum period were enrolled in the study. Cases and controls were enrolled in a ratio of 1:2, each enrolled case of preterm birth was followed by 2 control cases delivered at term gestation that were next on the register. There were 185 cases of preterm deliveries and 370 controls of term delivery. Multivariate regression analysis was done and the variables were hierarchically grouped into three groups: The first group involved demographic variables that were put in the regression model as Step 1. The second group was made up of other potential factors that were put in the regression model as the second step. The third group was periodontitis, as it was hypothesized to be a major predictor variable and this constituted the the third step of the regression model. Results: Significant association was found between periodontitis and preterm birth. Women who had periodontitis had 6 times the odds of giving birth to preterm birth babies compared to women who had no periodontitis (p<0.001) (95% CI 3.9, 10.4). Conclusion: Periodontitis is a risk factor for preterm birth and preventive solutions such as having a periodontitis screening tool for nurses and midwives during antenatal care consultations is highly recommended.

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Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study

Cited by 181 publications

References 53 publications

Changing trends of birth weight with maternal age: a cross-sectional study in Xi'an city of Northwestern China

Changing trends of birth weight with maternal age: a cross-sectional study in Xi'an city of Northwestern China

Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

Assessing the association between periodontitis and preterm birth : A case control study

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