Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017

Elmerdahl Frederiksen, Line; Ølgaard, Sofie Møller; Roos, Laura; Petersen, Olav Bjørn; Rode, Line; Hartwig, Tanja; Ekelund, Charlotte Kvist; ,; Vogel, Ida

doi:10.1111/aogs.14713

Cited by 7 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, studies had indicated that the incidence of fetal chromosomal aneuploidy was higher in women over 35 years of age [5,21,25] . Most researchers believed that it was mainly due to the occurrence of premature separation of sister chromatids, non-disjunction in meiosis II, and reverse segregation during the development of oocytes in older women, which can signi cantly increase the incidence of trisomy in fetal tissue chromosome [26,27] .…”

Section: Discussionmentioning

confidence: 99%

The relationship between fetal tissue chromosomal karyotype and clinical characteristics in patients with spontaneous abortion: a retrospective study

Liu,

Yang,

Huo

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Abnormal fetal tissue chromosome karyotypes are one of the important pathogenic factors for spontaneous abortion (SA). To analyze the characteristics of fetal tissue chromosomal karyotype in 778 women with a history of SA and its relationship with clinical features. Methods A retrospective study collected maternal age, body mass index (BMI), gestational weeks at miscarriage, the number of previous pregnancy losses and fetal tissue karyotypes CNV-seq data of 778 SA couples from Lanzhou University Second Hospital from October 2019 to December 2023, and described the characteristics of fetal tissue chromosomal karyotype and its relationship with clinical features. Results In our study, 432 patients (55.53% of total) had abnormal fetal tissue chromosomal karyotypes, with the highest incidence being trisomy syndrome (46.99%,203/432). Advanced maternal age(>35 years), early pregnancy(<12 weeks), and a history of less than four previous pregnancy losses were all identified as risk factors for fetal tissue chromosomal abnormalities. Conclusion The results of this study indicate that fetal tissue chromosomal abnormalities are the primary factor leading to SA. Additionally, advanced maternal age(>35years), early pregnancy(<12 weeks=, and the fewer number of previous pregnancy losses(≤ 4 times) are associated with a higher risk of fetal tissue chromosomal abnormalities following miscarriage.

show abstract

Section: Discussionmentioning

confidence: 99%

The relationship between fetal tissue chromosomal karyotype and clinical characteristics in patients with spontaneous abortion: a retrospective study

Liu,

Yang,

Huo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Although insignificant, several reasons may provide an explanation. First, the proportion of pregnancies with advanced maternal age, a well-established risk factor of chromosomal abnormalities in the offspring [ 34 ], almost doubled after the termination of the One-Child Policy [ 35 ]. Second, new genetic techniques promote the detection and correct categorization of chromosomal issues [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Trend of Mortality Due to Congenital Anomalies in Children Younger Than 5 Years in Eastern China, 2012-2021: Surveillance Data Analysis

Dong,

Guo,

Wang

et al. 2024

JMIR Public Health Surveill

View full text Add to dashboard Cite

Background As one of the leading causes of child mortality, deaths due to congenital anomalies (CAs) have been a prominent obstacle to meet Sustainable Development Goal 3.2. Objective We conducted this study to understand the death burden and trend of under-5 CA mortality (CAMR) in Zhejiang, one of the provinces with the best medical services and public health foundations in Eastern China. Methods We used data retrieved from the under-5 mortality surveillance system in Zhejiang from 2012 to 2021. CAMR by sex, residence, and age group for each year was calculated and standardized according to 2020 National Population Census sex- and residence-specific live birth data in China. Poisson regression models were used to estimate the annual average change rate (AACR) of CAMR and to obtain the rate ratio between subgroups after adjusting for sex, residence, and age group when appropriate. Results From 2012 to 2021, a total of 1753 children died from CAs, and the standardized CAMR declined from 121.2 to 62.6 per 100,000 live births with an AACR of –9% (95% CI –10.7% to –7.2%; P<.001). The declining trend was also observed in female and male children, urban and rural children, and neonates and older infants, and the AACRs were –9.7%, –8.5%, –8.5%, –9.2%, –12%, and –6.3%, respectively (all P<.001). However, no significant reduction was observed in children aged 1-4 years (P=.22). Generally, the CAMR rate ratios for male versus female children, rural versus urban children, older infants versus neonates, and older children versus neonates were 1.18 (95% CI 1.08-1.30; P<.001), 1.20 (95% CI 1.08-1.32; P=.001), 0.66 (95% CI 0.59-0.73; P<.001), and 0.20 (95% CI 0.17-0.24; P<.001), respectively. Among all broad CA groups, circulatory system malformations, mainly deaths caused by congenital heart diseases, accounted for 49.4% (866/1753) of deaths and ranked first across all years, although it declined yearly with an AACR of –9.8% (P<.001). Deaths due to chromosomal abnormalities tended to grow in recent years, although the AACR was not significant (P=.90). Conclusions CAMR reduced annually, with cardiovascular malformations ranking first across all years in Zhejiang, China. Future research and practices should focus more on the prevention, early detection, long-term management of CAs and comprehensive support for families with children with CAs to improve their survival chances.

show abstract

Infertility following trisomic pregnancies: A nationwide cohort study

Wedenoja,

Pihlajamäki,

Gissler

et al. 2024

Intl J Gynecology & Obste

View full text Add to dashboard Cite

ObjectiveTo study whether gynecologic or reproductive disorders show association with trisomic conceptions.MethodsThis nationwide cohort study utilized the Registry of Congenital Malformations to identify women who had a trisomic pregnancy (n = 5784), either with trisomy 13 (T13; n = 351), trisomy 18 (T18; n = 1065) or trisomy 21 (T21; n = 4369) from 1987 to 2018. We used the Finnish Maternity cohort to match the cases to population controls (n = 34 422) on the age, residence, and timing of pregnancy. These data were cross‐linked to the ICD‐10 diagnoses of the national Care Registry for Health Care data on specialized health care in Finland during 1996 to 2019. Both inflammatory (ICD‐10 diagnoses: N70–N77) and noninflammatory disorders of the genital tract (N80–N98) were studied. Crude odds ratios (ORs) with 95% CIs were calculated for associations between diagnoses and trisomic conceptions.ResultsThe diagnosis of female infertility (N97) at any time was associated with trisomic conceptions (OR: 1.19, 95% CI: 1.08–1.32). In the subgroup analysis, this association was found for T18 (OR: 1.29, 95% CI: 1.03–1.61) and T21 (OR: 1.17, 95% CI: 1.04–1.32), but not for T13 (OR: 1.15, 95% CI: 0.75–1.72). When restricting the timing of the diagnosis of female infertility, an elevated OR was found only after the index pregnancy (OR: 1.81, 95% CI: 1.56–2.09). These increased odds for infertility after trisomic conceptions were observed both in women <35 years (T18 OR: 1.91, 95% CI: 1.21–3.00; T21 OR: 1.68, 95% CI: 1.31–2.14) and in women ≥35 years (T18 OR: 2.17, 95% CI: 1.40–3.33; T21 OR: 1.87; 95% CI: 1.47–2.39), but not after T13 conceptions.ConclusionOur observational data suggest a link between trisomic conceptions and subsequent diagnoses of infertility but do not demonstrate causality. These data implicate that partially similar mechanisms might predispose to trisomy and infertility, regardless of maternal age.

show abstract

Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017

Cited by 7 publications

References 25 publications

The relationship between fetal tissue chromosomal karyotype and clinical characteristics in patients with spontaneous abortion: a retrospective study

The relationship between fetal tissue chromosomal karyotype and clinical characteristics in patients with spontaneous abortion: a retrospective study

Trend of Mortality Due to Congenital Anomalies in Children Younger Than 5 Years in Eastern China, 2012-2021: Surveillance Data Analysis

Infertility following trisomic pregnancies: A nationwide cohort study

Contact Info

Product

Resources

About