Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study

O’Keeffe, Linda M; Kearney, Patricia M.; Greene, Richard A.; Zuccolo, Luisa; Tilling, Kate; Lawlor, Debbie A.; Howe, Laura D

doi:10.1016/j.drugalcdep.2015.02.035

Cited by 15 publications

(10 citation statements)

References 34 publications

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“…However, previous studies have indicated that drinking alcohol in pregnancy might not be associated with BW growth. 33 , 34 Unfortunately, it is not possible to draw conclusions from the present study regarding a linear trend in alcohol intake during pregnancy.…”

Section: Discussionmentioning

confidence: 61%

Changes in Socioeconomic Inequality of Low Birth Weight and Macrosomia in Shaanxi Province of Northwest China, 2010–2013

et al. 2016

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Socioeconomic disparities in birth weights (BWs) are associated with lifelong differences in health and productivity. Understanding socioeconomic disparities in BW is presently of concern to develop public health interventions that promote a good start in life in Northwest China. In the study, our objective is to investigate the socioeconomic disparities in low and high BW from 2010 to 2013 in this region.Those single live births were recruited using a stratified multistage sampling method in Shaanxi province from August to December 2013. Data were collected with a structured questionnaire and a review of birth certificates. Socioeconomic status (SES) was stratified based on the calculated household wealth index. Prevalence differences (PDs) and concentration indices (CIs) were used to depict the SES inequality of low BW (LBW) and macrosomia.Information for 28722 single live births born were obtained in Shaanxi province. From 2010 to 2013, the overall rates of LBW decreased, and the difference in LBW across differing SES groups decreased by 0.7% (boys, 0.4%; girls, 0.8%). From 2010 to 2013, the overall rates of macrosomia increased by 14.3% (boys, 17.5%; girls, 7.8%), whereas the PDs in macrosomia across various SES groups remained unchanged. From 2010 to 2013, concentration indices for SES inequalities in LBW and macrosomia confirmed the results shown by differences in prevalence. Compared with mothers of high SES, those in low SES group were significantly older, less educated, engaged in farming with less availabile healthcare, and engaged in unhealthy lifestyles (eg, exposure to secondhand smoke) during pregnancy, regardless of the baby's sex.From 2010 to 2013, in Shaanxi province, the negative association between socioeconomic status and LBW weakened. Rates of macrosomia were higher in those of high SES, but the SES disparities varied insignificantly over the same time. Our findings may provide valuable insights to direct healthcare policies for pregnant women to reduce inequalities in health, quality of life, and productivity for their children as they age into adulthood.

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Section: Discussionmentioning

confidence: 61%

Changes in Socioeconomic Inequality of Low Birth Weight and Macrosomia in Shaanxi Province of Northwest China, 2010–2013

et al. 2016

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“…Our main model also included a random intercept for child and a random slope for age to account for repeated measurements within subject and to adjust for heterogeneity in trends over time [30,31]; this model allows for correlated repeated weight measurements and varying number of measures per child. This modeling approach has been shown to produce good model fit in this and several other cohorts [9,[32][33][34][35][36][37].…”

Section: Growth Trajectories Modelmentioning

confidence: 78%

Prenatal Ambient Particulate Matter Exposure and Longitudinal Weight Growth Trajectories in Early Childhood

Rosofsky

Fabian

Cuba

et al. 2020

IJERPH

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Air pollution exposure during pregnancy has been associated with impaired fetal growth and postnatal weight gain, but few studies have examined the effect on weight growth trajectories. We examine the association between validated 1 km2 resolution particulate matter (PM2.5) concentrations, averaged over pregnancy, and sex-specific growth trajectories from birth to age six of participants in the Boston-based Children’s HealthWatch cohort (4797 participants, 84,283 measures). We compared weight trajectories, predicted using polynomial splines in mixed models, between prenatal PM2.5 above or below the median (9.5 µg/m3), and examined birth weight as an effect modifier. Females exposed to average prenatal PM2.5 ≥ 9.5 µg/m3 had higher weights compared to females exposed to < 9.5 µg/m3 throughout the study period (0.16 kg at 24 months, 0.61 kg at 60 months). In males, higher prenatal PM2.5 exposure was associated with significantly lower weights after 24 months of age, with differences increasing with time (−0.17 at 24 months, −0.72 kg at 60 months). Associations were more pronounced among low birth weight (<2500 g) females, but did not differ by birth weight status in males. Our findings demonstrate the complex association between air pollution exposures and childhood weight trajectories and emphasize the importance of sex-stratified analyses.

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“…Heavy alcohol exposure during early life or prepregnancy is associated with reduced birthweight and adverse pregnancy outcomes, which may have a persistent influence on childhood growth. A recent study of over 7000 British mother‐child dyads (ALSPAC birth cohort) demonstrated a similar association in young children; however, this was no longer evident at the age of 10 years . Previous reports have suggested that the relationship between excess maternal alcohol intake and delayed weight in later childhood may be explained by maternal nutritional intake, genetics, socioeconomic status, and ethnicity…”

Section: Discussionmentioning

confidence: 91%

“…A recent study of over 7000 British mother-child dyads (ALSPAC birth cohort) demonstrated a similar association in young children; however, this was no longer evident at the age of 10 years. 45 Previous reports have suggested that the relationship between excess maternal alcohol intake and delayed weight in later childhood may be explained by maternal nutritional intake, genetics, socioeconomic status, and ethnicity. 46 We also found associations between gestational hypertension and offspring body composition independent of maternal BMI.…”

Section: Discussionmentioning

confidence: 99%

Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

et al. 2019

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Summary Background Maternal obesity has been implicated in the origins of childhood obesity through a suboptimal environment in‐utero. Objective We examined relationships of maternal early pregnancy body mass index (BMI), overweight/obesity, and plasma biomarkers of obesity, inflammation, insulin resistance, and placental function with measures of childhood BMI and adiposity. Methods BMI z‐score, sum of skinfold thicknesses (SST), body fat percentage (BFP, by bioelectrical impedance), and waist, arm, and hip circumferences were measured in 1173 6‐year‐old children of nulliparous pregnant women in the Screening for Pregnancy Endpoints (SCOPE) study, New Zealand. Relationships of maternal early pregnancy (15 weeks' gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment. Results 28.1% of mothers were classified as overweight and 10.1% with obesity; compared with normal weight mothers, the BFP of their children were 5.3% higher (0.16 SD [95% CI, 0.04‐0.29] p = .01) and 7.8% higher (0.27 [0.08‐0.47] p = .006) with comparable values for BMI z‐score and arm, waist, and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child's SST, BMI z‐score, hip circumference, and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity. Conclusion In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity; similar associations were observed with PlGF, which may imply a role for placenta function in the developmental programming of childhood obesity risk.

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Maternal alcohol use during pregnancy and offspring trajectories of height and weight: A prospective cohort study

Cited by 15 publications

References 34 publications

Changes in Socioeconomic Inequality of Low Birth Weight and Macrosomia in Shaanxi Province of Northwest China, 2010–2013

Changes in Socioeconomic Inequality of Low Birth Weight and Macrosomia in Shaanxi Province of Northwest China, 2010–2013

Prenatal Ambient Particulate Matter Exposure and Longitudinal Weight Growth Trajectories in Early Childhood

Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

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