Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR) I. Priming for anti-paternal GVHR by gestation

Voisin, J.; Monnot, P; Voisin, G A

doi:10.1016/0165-0378(86)90001-x

Cited by 8 publications

(1 citation statement)

References 16 publications

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“…It was this concept that led to placental extracts being considered as immunotherapy for cancer patients (Govallo, 1993;Voisin et al, 1986), and such 'immunoembryotherapy' has been promoted by the Center for Empirical Medicine in the U.S.A. (Anon., 1997). Since HPE has immunomodulatory ability (Voisin et al, 1986;Govallo, 1993;Ansari et al, 1994;Anon., 1997) and immunosuppression is the hallmark of VL (Carvalho et al, 1981), it appears possible that HPE treatment of VL cases could be beneficial. In the present study, therefore, mice and hamsters harbouring established infections with antimony-sensitive (Sb S ) or antimonyresistant (Sb R ) strains of Leishmania donovani were treated, intraperitoneally, with doses of HPE.…”

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confidence: 99%

Human placental extract offers protection against experimental visceral leishmaniasis: a pilot study for a phase-I clinical trial

Chakraborty

Basu

Sen

et al. 2008

Annals of Tropical Medicine & Parasitology

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An aqueous extract of human placenta (HPE) was found to offer protection against established experimental visceral leishmaniasis in BALB/c mice and hamsters, whether the Leishmania donovani strain involved was one that was sensitive or resistant to pentavalent antimony. Intraperitoneal administration of the extract, into mice or hamsters that had been infected 2 months previously, led to antileishmanial T-cell proliferation among splenic mononuclear cells, the generation of host-protective cytokines (interferon-gamma, tumour necrosis factor and interleukin-12) and the upregulation of the expression of inducible nitric oxide synthase (and subsequent NO generation) in splenocytes. Furthermore, splenic macrophages from the HPE-treated mice showed increased generation of reactive oxygen species and enhanced surface expression of antigens of major histocompatibility complex class II (MHCII), and the extract restored the otherwise-defective antigen-presenting ability of the macrophages. Thus, in mice and hamsters infected with L. donovani, HPE therapy can stimulate both arms of the host's immune system and favour the complete resolution of the leishmanial infection. Among five human cases of visceral leishmaniasis, 30 daily intramuscular injections of HPE, at doses much lower than those used in the experimental infections, also gave very promising results. Based on the results of this pilot study, a further evaluation of the efficacy of HPE therapy, which may offer a cost-effective way of improving the treatment of antimony-resistant cases of visceral leishmaniasis, is being undertaken.

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confidence: 99%

Human placental extract offers protection against experimental visceral leishmaniasis: a pilot study for a phase-I clinical trial

Chakraborty

Basu

Sen

et al. 2008

Annals of Tropical Medicine & Parasitology

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Effects of feto-maternal major histocompatibility differences on litter size in pigs

Renard¹

1988

Early Pregnancy Loss

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Immunological Difficulties and Requirements for Immune Manipulations in the Field of Reproduction

Voisin¹

1988

Contraception Research for Today and the Nineties

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Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR) I. Priming for anti-paternal GVHR by gestation

Cited by 8 publications

References 16 publications

Human placental extract offers protection against experimental visceral leishmaniasis: a pilot study for a phase-I clinical trial

Human placental extract offers protection against experimental visceral leishmaniasis: a pilot study for a phase-I clinical trial

Effects of feto-maternal major histocompatibility differences on litter size in pigs

Immunological Difficulties and Requirements for Immune Manipulations in the Field of Reproduction

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