Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: a meta-analysis

Thomopoulos, Thomas; Ntouvelis, Evangelos; Diamantaras, Andreas-Antonios; Tzanoudaki, Marianna; Baka, Margarita; Hatzipantelis, Emmanuel; Kourti, Maria; Polychronopoulou, Sophia; Sidi, V.; Stiakaki, Eftichia; Moschovi, Maria; Καντζάνου, Μαρία; Petridou, Eleni

doi:10.1016/j.canep.2015.08.009

Cited by 47 publications

(36 citation statements)

References 49 publications

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“…154 Subsequent case-control studies have found maternal consumption of coffee during pregnancy to be associated with an increased risk of ALL, AML, and possibly infant leukemia, while others have failed to find an association, as summarized in a recent meta-analysis. 155 There is some evidence from these studies that the increased risk of leukemia with maternal coffee consumption may be more pronounced among children born to non-smoking mothers. 156,157 Similarly, cola-based drinks have been associated with increased risk of childhood ALL (summary OR=1.31, 95% CI: 1.09–2.47), while reduced risks have been reported with maternal tea consumption during pregnancy (summary OR=0.85, 95% CI: 0.75–0.97).…”

Section: Dietary Risk Factors For Childhood Leukemiamentioning

confidence: 99%

“…156,157 Similarly, cola-based drinks have been associated with increased risk of childhood ALL (summary OR=1.31, 95% CI: 1.09–2.47), while reduced risks have been reported with maternal tea consumption during pregnancy (summary OR=0.85, 95% CI: 0.75–0.97). 155 A general limitation of those studies is the lack of information on the type of drinks (e.g., caffeinated or not, green or black tea), which contain different nutrients and other compounds with either anti-or pro carcinogenetic properties.…”

Section: Dietary Risk Factors For Childhood Leukemiamentioning

confidence: 99%

“…175 Child’s consumption of cola-based drinks does not appear to be associated with leukemia, in contrast to maternal consumption during pregnancy. 155 …”

Section: Dietary Risk Factors For Childhood Leukemiamentioning

confidence: 99%

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Childhood Leukemia and Primary Prevention

Whitehead

Metayer

Wiemels

et al. 2016

Current Problems in Pediatric and Adolescent Health Care

110

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Leukemia is the most common pediatric cancer, affecting 3,800 children per year in the United States. Its annual incidence has increased over the last decades, especially among Latinos. Although most children diagnosed with leukemia are now cured, many suffer long-term complications, and primary prevention efforts are urgently needed. The early onset of leukemia – usually before age five – and the presence at birth of “pre-leukemic” genetic signatures indicate that pre- and postnatal events are critical to the development of the disease. In contrast to most pediatric cancers, there is a growing body of literature – in the United States and internationally – that has implicated several environmental, infectious, and dietary risk factors in the etiology of childhood leukemia, mainly for acute lymphoblastic leukemia, the most common subtype. For example, exposures to pesticides, tobacco smoke, solvents, and traffic emissions have consistently demonstrated positive associations with the risk of developing childhood leukemia. In contrast, intake of vitamins and folate supplementation during the pre-conception period or pregnancy, breastfeeding, and exposure to routine childhood infections have been shown to reduce the risk of childhood leukemia. Some children may be especially vulnerable to these risk factors, as demonstrated by a disproportionate burden of childhood leukemia in the Latino population of California. The evidence supporting the associations between childhood leukemia and its risk factors – including pooled analyses from around the world and systematic reviews – is strong; however, the dissemination of this knowledge to clinicians has been limited. To protect children’s health, it is prudent to initiate programs designed to alter exposure to well-established leukemia risk factors rather than to suspend judgement until no uncertainty remains. Primary prevention programs for childhood leukemia would also result in the significant co-benefits of reductions in other adverse health outcomes that are common in children, such as detriments to neurocognitive development.

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Section: Dietary Risk Factors For Childhood Leukemiamentioning

confidence: 99%

Section: Dietary Risk Factors For Childhood Leukemiamentioning

confidence: 99%

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Childhood Leukemia and Primary Prevention

Whitehead

Metayer

Wiemels

et al. 2016

Current Problems in Pediatric and Adolescent Health Care

110

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“…A reduced risk of ALL was also associated with consumption of food items from the Mediterranean diet (fruit, vegetables, fish and legumes) together with supplementation of folic acid and multivitamins prior to conception [16]. Thomopoulos et al [17] found a correlation between the consumption of coffee and an increased risk of childhood leukaemia. Similar results were found for the consumption of cola.…”

Section: Main Bodymentioning

confidence: 99%

Insights into maternal diet for the prevention of childhood leukaemia

Cantarella¹,

Ragusa²,

Tosi³

2018

Hematol Leuk

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Nutrition plays a crucial role in wellbeing and is being increasingly recognised as an environmental factor in the development of disease. During pregnancy, maternal diet influences foetal development, playing a role not only in the prevention of neural tube defects and malformations, but also in the susceptibility to disease later in life. Certain micronutrients, such as folates, are involved in the maintenance of genome integrity, which is compromised in cancer. A deficiency in these nutrients can therefore be relevant in carcinogenic processes. The early onset of childhood leukaemia implies that it originates already in utero, where environmental factors can interfere with the healthy development of the foetus. Population studies have found an association between maternal intake of folic acid and multivitamins and a reduced risk in the development of leukaemia in the offspring. Although the supplementation of vitamins is recommended during pregnancy, the adequate dosage and nutrient combinations need to be further elucidated to fully maximise their protective role.

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“…Various in utero and early childhood exposures have been investigated in the aetiology of childhood ALL [9, 10]. These include breast feeding [11], infection history [12], childcare/day care attendance [11, 12], maternal smoking [13, 14], alcohol [15, 16], caffeine [15, 17], folic acid [18, 19], iron [20], radiation [8], household paints [21], chemicals [22], pesticides [23, 24], and herbicides [25]. The weight of supporting evidence for the role of each exposure in the aetiology of childhood ALL varies.…”

Section: Introductionmentioning

confidence: 99%

Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post‐natal environmental exposures and risk of childhood acute lymphoblastic leukaemia

Timms

Relton

Sharp

et al. 2019

Intl Journal of Cancer

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The aetiology of childhood acute lymphoblastic leukaemia (ALL) is unclear. Genetic abnormalities have been identified in a number of ALL cases, although these alone are not sufficient for leukaemic transformation. Various in utero and post-natal environmental exposures have been suggested to alter risk of childhood ALL. DNA methylation patterns can be influenced by environmental exposures, and are reported to be altered in ALL, suggesting a potential mediating mechanism between environment and ALL disease risk. To investigate this, we used a ‘meet in the middle’ approach, investigating the overlap between exposure-associated and disease-associated methylation change. Genome-wide DNA methylation changes in response to possible ALL-risk exposures (i.e. breast feeding, infection history, day care attendance, maternal smoking, alcohol, caffeine, folic acid, iron, and radiation exposure) were investigated in a sub-population of the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort using an epigenome-wide association study (EWAS) approach (n=861-927), and compared to a list of ALL disease-associated methylation changes compiled from published data. Hypergeometric probability tests suggested that the number of directionally concordant gene methylation changes observed in ALL disease and in response to the following exposures; maternal radiation exposure (p=0.001), alcohol intake (p=0.006); sugary caffeinated drink intake during pregnancy (p=0.045); and infant day care attendance (p=0.003), were not due to chance. Data presented suggests that DNA methylation may be one mediating mechanism in the multiple hit pathway needed for ALL disease manifestation.

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Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: a meta-analysis

Cited by 47 publications

References 49 publications

Childhood Leukemia and Primary Prevention

Childhood Leukemia and Primary Prevention

Insights into maternal diet for the prevention of childhood leukaemia

Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post‐natal environmental exposures and risk of childhood acute lymphoblastic leukaemia

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