Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth

Abstract

IntroductionVitamin D deficiency in pregnant women may result in reduced neonatal development due to the fact that systemic vitamin D status during fetal life depends on maternal concentrations. Some authors reported significant differences in neonatal anthropometric measurements depending on maternal vitamin D concentrations.ObjectiveThe aim of this study is to evaluate the relationship between maternal and cord blood concentrations of vitamin D and neonatal anthropometric measurements at birth.Materials and methodsThis study included 94 pregnant women, at term, who delivered at the Department of Obstetrics, Women’s Diseases and Gynecological Oncology, Medical University of Warsaw. Total serum 25(OH)D concentration was measured in mother–child pairs, and newborn anthropometric data were collected. A multiple regression analysis was used for statistical analysis.ResultsNo relationship between maternal and neonatal cord blood vitamin D concentrations vs. neonatal weight, length, head, and chest circumference at birth was found (p > 0.05). Severe vitamin D deficiency (<10 ng/ml) was detected in 10.6%, deficiency (10–20 ng/ml) in 39.4%, insufficiency (20–30 ng/ml) in 39.4%, and optimal vitamin D concentration (>30 ng/ml) only in 10.6% of the pregnant women. Cord blood vitamin D deficiency (<20 ng/ml) was found in 28.7% of the neonates.ConclusionNo differences between neonatal anthropometric measurements of infants born to mothers with normal and deficient vitamin D concentrations were found.

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

“…The positive association between vitamin D intake from food and supplements and maternal VDD is in agreement with some [34,41,[43][44][45][46][47][48], but not all [39] of the previous studies. It appears that vitamin D intake from food and supplements contributed signi cantly to 25OHD level in population, in which sun exposure is minimum or dermal synthesis of 25OHD is limited.…”

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status of healthy Malaysian pregnant women

“…The positive association between vitamin D intake from food and supplements and maternal VDD is in agreement with most of the previous ndings [39,46,[49][50][51][52][53][54]] except a study [44]. It was found that vitamin D intake from foods and supplements contributed signi cantly to 25OHD level in population exposure to sun is minimum or dermal synthesis of 25OHD is limited.…”

Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study

“…Additionally, the percentage that met criteria for vitamin D deficiency (23%) or insufficiency (27%) were much lower than in other populations where the majority met these criteria (Table S5). The higher mean 25(OH)D could be due to higher ultraviolet indexes and/or exposure in this California population or fortification of vitamin D in several foods within the United States; previous studies have shown similarly higher umbilical cord blood serum 25(OH)D3 (59–67 nmol/L) in United States Caucasians (from Ohio and Pennsylvania) [Bodnar et al, ; Seto et al, ] compared to Europeans (17–67 nmol/L) [Delvin, Salle, Glorieux, Adeleine, & David, ; Pludowski et al, ; Wierzejska et al, ].…”