Maternal and Cord Serum Levels of Tissue Polypeptide Antigen (TPA) in Normal Pregnancies

Bremme, Katarina; Eneroth, P.; Nilsson, B.; Olsson, Magnus

doi:10.1159/000299020

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…Thus our results are in clear contrast to the data of Bremme et al [2], who cal culated a half-life of about 7.5 days. According to our data, the half-life of TPA in plasma is less than 4 days.…”

Section: Discussioncontrasting

confidence: 99%

“…Delivery itself had no influence on the TPA levels. A significant correlation existed between placental weight and maternal plasma concentration [2]. In contrast, our own data [4] showed elevated TPA levels already in early pregnancy and a sig nificant negative correlation between TPA levels and pla cental as well as fetal weight in patients with hypertensive disorders of pregnancy.…”

contrasting

confidence: 59%

“…Bremme et al [2] found no change in TPA during parturition. Lelle et al [5] reported a general elevation of TPA during parturition, but the exact timing of blood sampling was not men tioned.…”

Section: Discussionmentioning

confidence: 94%

“…Tissue polypeptide antigen (TPA) occurs in various tis sues such as cervical mucus, amniotic fluid, placental tis sue [1] and in many tumours [2], It is a well-established marker for breast cancer [3] and is used in the follow-up of patients after primary treatment. Tumour-associated an tigens such as TPA can be demonstrated on the tumour cell itself or circulating freely in serum.…”

Section: Introductionmentioning

confidence: 99%

“…TPA is known to be present in large amounts in placental tissue and mater nal serum levels increase during pregnancy. Bremme et al [2] reported that the TPA levels in sera of pregnant wom en up to the 28th gestational week did not differ from those of non-pregnant women. From that time on, the lev els increased until parturition.…”

mentioning

confidence: 98%

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Tissue Polypeptide Antigen during Parturition and Puerperium

Bergant

Kirchler²,

Schröcksnadel³

et al. 1996

Gynecol Obstet Invest

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The tumour and cytoskeleton protein tissue polypeptide antigen (TPA) was determined in maternal serum taken during the second stage of labour and on the 4th postpartum day. Pregnant women at term (weeks 38–42) served as a control group. TPA levels of women during parturition (median 169 U/l) were higher than those of the control group (median 108.5 U/l) and those of women on the 4th postpartum day (median 66.5 U/l); p < 0.0001 in each case. The correlation between duration of labour and TPA concentration was positive and significant (r_s = 0.3; p = 0.03). A significant negative correlation was found between placental weight and maternal serum TPA levels during parturition (rs = ––0.3; p = 0.03). The decline of TPA after delivery indicated a serum half-life for TPA of less than 4 days.

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Section: Discussioncontrasting

confidence: 99%

contrasting

confidence: 59%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 98%

See 3 more Smart Citations

Tissue Polypeptide Antigen during Parturition and Puerperium

Bergant

Kirchler²,

Schröcksnadel³

et al. 1996

Gynecol Obstet Invest

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Immunoradiometrical measurement of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) in pregnancy and at delivery

Itahashi¹,

Inaba

Fukazawa

et al. 1988

Arch Gynecol Obstet

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Using conventional radioimmunoassay kits, we measured concentrations of two cancer-related antigens, tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) throughout gestation and at delivery. The maternal serum was collected from 147 pregnant women between 5 and 43 weeks gestation and 27 women were studied at delivery at which time samples of maternal blood, umbilical artery and vein blood as well as amniotic fluid were collected. The various concentrations of TPA and CA125 were compared with placental weight and infant birth weight. The results are summarized as follows: (1) Mean TPA levels in maternal serum increased with advancing gestation and rose above 110 U/l (upper non-pregnant limit) from 35 weeks onwards. Mean CA125 levels rose above 35 U/ml (normal non-pregnant upper limit) before 9 weeks gestation and thereafter fell. Both levels were markedly raised immediately after delivery. (2) In umbilical artery and vein serum, mean TPA levels were slightly raised. However, there were no significant differences between TPA levels in maternal serum and matched serum from the umbilical artery and vein. Mean umbilical CA125 levels were below 35 U/ml, while mean CA125 levels were significantly higher in the corresponding maternal serum. (3) The concentrations of TPA and CA125 were extremely high in amniotic fluid. The mean values reached 3604 U/l and 2187 U/ml, respectively. (4) None of the concentrations of TPA and CA125 in those pregnancy-related body fluids correlated significantly with birth weight, placental weight or fetal sex. These findings suggest that the production of these two cancer-related antigens is not by the fetus but the placenta.

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A comparison between the composition of maternal peripheral plasma and plasma collected from the retroplacental compartment at caesarean section

Norman

Eriksson

Eneroth

1989

Arch Gynecol Obstet

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In the pregnant uterus unique immunological conditions must prevail. Since compounds of possible fetoplacental origin may modulate the local maternal immunological response, higher concentrations of such compounds in the vicinity of the conceptus might be expected. We have measured the concentrations of several compounds in peripheral and retroplacental plasma, mainly by immunological methods, from women delivered by caesarean section in pregnancy week 38-40. Significantly higher (P less than 0.001) retroplacental concentrations were found for human placental lactogen, prolactin, alpha-fetoprotein, tissue polypeptide antigen, non-conjugated estriol and progesterone. Peripheral plasma levels were significantly higher for cortisol (P less than 0.01), transcortin (P less than 0.001) and sex-hormone binding globulin (P less than 0.002). No difference was found for albumin, alpha 2-macroglobulin, estradiol, placental alkaline phosphatase and human chorionic gonadotrophin. Significant correlations between retroplacental and maternal peripheral plasma levels were found for progesterone, cortisol, estradiol, estriol, transcortin, sex-hormone binding globulin, prolactin, human placental lactogen, human chorionic gonadotrophin, placental alkaline phosphatase, albumin and alpha 2-macroglobulin. There were also significant correlations between estradiol and sex-hormone binding globulin as well as transcortin in peripheral maternal plasma.

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Maternal and Cord Serum Levels of Tissue Polypeptide Antigen (TPA) in Normal Pregnancies

Cited by 13 publications

References 10 publications

Tissue Polypeptide Antigen during Parturition and Puerperium

Tissue Polypeptide Antigen during Parturition and Puerperium

Immunoradiometrical measurement of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) in pregnancy and at delivery

A comparison between the composition of maternal peripheral plasma and plasma collected from the retroplacental compartment at caesarean section

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