Maternal and Fetal Effects from Substance Use

Rayburn, William F.

doi:10.1016/j.clp.2007.09.001

Cited by 30 publications

(11 citation statements)

References 12 publications

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“…Medical complications include: (1) chronic vascular diseases, secondary to conditions such as hypertension; (2) diabetes mellitus; renal disorders; (3) collagen vascular diseases; (4) asthma; and (5) infections and malnutrition (Catov et al, 2008). The adverse environmental exposures include medication use (Rayburn et al, 2007); alcohol abuse; and cigarette smoking (Aagaard‐Tillery et al, 2008). Furthermore, numerous epidemiological studies indicate that those who are born SGA are at increased risk for hypertension, insulin resistance syndrome, and fatal or non‐fatal coronary events in adulthood or other causes of death (Levy‐Marchal and Jaquet, 2004).…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive medication use during pregnancy and the risk of major congenital malformations or small‐for‐gestational‐age newborns

Nakhai-Pour

Rey

Bérard

2010

Birth Defects Research Pt B

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Section: Introductionmentioning

confidence: 99%

Antihypertensive medication use during pregnancy and the risk of major congenital malformations or small‐for‐gestational‐age newborns

Nakhai-Pour

Rey

Bérard

2010

Birth Defects Research Pt B

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“…Also the psychiatric diseases affected the fetal development especially due to the pharmacological treatments used: benzodiazepine, sodium valproate, lithium carbonate. Unlike as found in the literature [10][11][12], in our sample the mothers had a perfect compliance to the prenatal examinations: in 91% of the cases at least four obstetric visits have been performed (between 5 and 10 for each mother) and the mean number of ecographies carried out was 4.8 (between 2 and 10 for each pregnancy).…”

Section: Resultsmentioning

confidence: 80%

Drug addiction during pregnancy: Correlations between the placental health and the newborn's outcome – Elaboration of a predictive score

Domenici

Cuttano

Nardini

et al. 2009

Gynecological Endocrinology

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During pregnancy, drug addiction represents one of the most dangerous situations. Each drug can badly affect the fetal development and, when the pregnancy is over, the negative influence continues in the newborn which is exposed to many risks, in particular the withdrawal syndrome. Since it is difficult to predict the newborn's outcome only on the basis of the kind of drug assumed by the mother during pregnancy, we propose the idea of a score based on the placenta's state of health. The aim of the study is to correlate the placental score to the withdrawal symptoms graveness. Our retrospective study includes 35 newborns exposed in uterus to illegal and legal drugs. We used the Finnegan's scoring system to quantify withdrawal symptoms and the placental score, based on the anatomopathological analysis, to assess the placenta's health. The newborns included in our study have been divided into two groups depending on the result of the placental score (< or =2 or > or =3). We found a significant statistical difference between the newborns whose placental score was low (< or =2) and those whose score was high (> or =3): the second group showed severe withdrawal symptoms for a longer time during the hospital stay (p = 0.014).

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“…Since, only a few pregnant women report drug use, the prevalence of treatment is low during pregnancy. Indeed, symptoms of crack cocaine addiction can be confused with the effects by other substances or with diseases (Rayburn, 2007). Thus, the number of newborns exposure to crack cocaine may be higher than the reported in the found literature.…”

Section: Discussionmentioning

confidence: 92%

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

Silveira

Santos

Tavella

et al. 2020

BJD

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Crack cocaine is a psychotropic and neurotoxic drug with high prevalence of consumption, considerate a public health problem and identified as risk factors to human health. Crack cocaine use among women in reproductive age increased in few year and the literature of the neonatal exposure to this substance during pregnancy are limited. Thus, this critical review discusses the major newborn outcomes reported in original studies, highlighting neurologic abnormalities and malformations outcomes. Sixteen studies were included in this review. The main physiological outcome found in newborn exposure to crack cocaine during gestation were lower birth weight; preterm birth; growth restricted infants; lower 5-minute Apgar scores; small for gestational age; and, small head circumference and congenital malformations. There were several negative neurologic and outcomes were reported on the literature. Moreover, there were still no consensus and the main criticism in this area is the limited studies available. RESUMOO crack é uma droga psicotrópica e neurotóxica, com alta prevalência de consumo, considerado um problema de saúde pública e tido como fator de risco para a saúde humana. O uso de crack entre mulheres em idade reprodutiva aumentou em poucos anos e a literatura sobre a exposição neonatal a essa substância durante a gravidez é limitada. Assim, esta revisão crítica discute os principais desfechos neonatais relatados em estudos originais, destacando como desfechos as anormalidades neurológicas e as malformações. Dezesseis estudos foram incluídos nesta revisão. Os principais desfechos fisiológicos encontrados na exposição do recém-nascido ao crack durante a gestação foram menor peso ao nascer; nascimento prematuro; restrição de crescimento; menores escores de Apgar no 5º minuto; pequeno para a idade gestacional; menor circunferência da cabeça e malformações congênitas. Houve vários desfechos neurológicos negativos e os resultados foram relatados na literatura. Ainda assim, não houve consenso na literatura e as principais críticas nesta área são os limitados estudos disponíveis.Palavras-chave: drogas ilícitas, gestação, recém-nascido.

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Maternal and Fetal Effects from Substance Use

Cited by 30 publications

References 12 publications

Antihypertensive medication use during pregnancy and the risk of major congenital malformations or small‐for‐gestational‐age newborns

Antihypertensive medication use during pregnancy and the risk of major congenital malformations or small‐for‐gestational‐age newborns

Drug addiction during pregnancy: Correlations between the placental health and the newborn's outcome – Elaboration of a predictive score

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

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