Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia

Livingston, Jeffrey; Barton, John R.; Park, Vicki; Haddad, Bassam; Phillips, Owen P.; Sibai, Baha M.

doi:10.1067/mob.2001.114691

Cited by 149 publications

(91 citation statements)

References 25 publications

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“…Among the 40 eligible articles, four studies were excluded because the genotype distribution in the control population deviated significantly from the HWE. [14][15][16][17] There were four overlapping casecontrol studies in two publications, [18][19][20][21] and we chose the most recent studies. 19,20 Thus, 34 reports were eligible.…”

Section: Study Characteristicsmentioning

confidence: 99%

Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia

2012

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A number of studies have investigated the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of pre-eclampsia (PE) in various populations and have delivered inconsistent results. Therefore, this meta-analysis of 36 case-control studies, comprising 4253 PE cases and 4950 controls, were assessed to evaluate a possible association. The pooled results showed that the MTHFR C677T polymorphism was significantly associated with PE (P ¼ 0.03, odds ratio (OR) ¼ 1.25, 95% confidence interval (CI) ¼ 1.02-1.54, for the additive comparison; P ¼ 0.04, OR ¼ 1.14, 95% CI ¼ 1.01-1.29, for the dominant genetic model). The results of the subgroup analysis showed that MTHFR 677T had the effect of increasing the PE risk for the recessive genetic model (Po0.0001, OR ¼ 1.76, 95% CI ¼ 1.33-2.33, P heterogeneity ¼ 0.28), the additive comparison (P ¼ 0.002, OR ¼ 2.09, 95% CI ¼ 1.31-3.31, P heterogeneity ¼ 0.08) and allele contrasts (P ¼ 0.03, OR ¼ 1.42, 95% CI ¼ 1.04-1.95, P heterogeneity ¼ 0.0001) in the Asians, while no evidence of an association between MTHFR C677T polymorphisms and PE was observed in the Caucasians. This meta-analysis suggests that the MTHFR C677T polymorphism is capable of causing PE susceptibility in the Asians but not in the Caucasians.

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Section: Study Characteristicsmentioning

confidence: 99%

Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia

2012

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“…Several studies have addressed the role of fetal inherited thrombophilias in pre-eclampsia, only three of them have included a small number of HELLP pregnancies (Table 5) (19,23,28,(33)(34)(35)(36)(37)(38). On the whole, there was no evidence for a strong association.…”

Section: Discussionmentioning

confidence: 72%

“…Previous association studies on thrombophilic genotypes and HELLP syndrome are summarized in Table 4 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Most of them were limited to a small sample size and genotyping was not done simultaneously for all of the three most common inherited thrombophilias.…”

Section: Discussionmentioning

confidence: 99%

Maternal Factor V Leiden Mutation Is Associated With HELLP Syndrome in Caucasian Women

Muetze

Leeners

Ortlepp

et al. 2008

Obstetrical &Amp; Gynecological Survey

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Objective. There is growing evidence that hypertensive pregnancy complications and other adverse pregnancy outcomes are associated with the presence of inherited or acquired thrombophilias. As hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G >A mutation and the methylenetetrahydrofolate reductase (MTHFR) 677C >T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. Design. The study was performed retrospectively in a case-control design. Sample. Seventy-one mother-child pairs with HELLP syndrome and 79 control mother-child pairs with uncomplicated pregnancies were included in the study. Methods. Genotyping of the three thrombophilic mutations was performed using the LightCycler technology. The chi-squared test was used for statistical analysis. Main outcome measures were maternal and fetal genotypes and their correlation with clinical parameters. Results. Maternal heterozygosity for factor V Leiden was significantly more prevalent in the HELLP group than in controls (OR 4.45, 95% CI 1.31-15.31). No significant association was observed for maternal prothrombin mutation or MTHFR polymorphism (p=0.894, p=0.189, respectively). The fetal genotype was not associated with HELLP syndrome for any of the three mutations investigated. Analysis of gene-gene interactions and genotype-phenotype correlation with respect to clinical parameters and perinatal outcome revealed no further differences. Conclusions. Our study confirms that women heterozygous for factor V Leiden have an increased risk of developing HELLP syndrome, while the most frequent mutations of the prothrombin and MTHFR gene do not play a major role in the pathogenesis of HELLP syndrome. AbstractObjective: There is growing evidence that hypertensive pregnancy complications and other adverse pregnancy outcomes are associated with the presence of inherited or acquired thrombophilias. As HELLP syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G>A mutation and the MTHFR 677C>T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. Design:The study was performed retrospectively in a cas-control design. Sample: 71 motherchild pairs with HELLP syndrome and 79 control mother-child pairs with uncomplicated pregnancies were included in the study. Methods: Genotyping of the three thrombophilic mutations was performed using the LightCycler technology. The chi-squared test was used for statistical analysis.

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“…We assessed the HWE by the same online calculator mentioned in the methods (http://ihg.gsf.de/cgi-bin/hw/hwa1.pl). However, the genotype distributions among the control populations in two 9,10 of the excluded studies were in agreement with HWE (P40.05) (Table 1). Thus, these papers did meet the inclusion criteria and should have been included in the meta-analysis.…”

mentioning

confidence: 75%

The association between methylenetetrahydrofolate reductase C677T polymorphism and pre-eclampsia risk: appraisal of a recent meta-analysis

Luo

Chen

2013

Hypertens Res

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Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia

Cited by 149 publications

References 25 publications

Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia

Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia

Maternal Factor V Leiden Mutation Is Associated With HELLP Syndrome in Caucasian Women

The association between methylenetetrahydrofolate reductase C677T polymorphism and pre-eclampsia risk: appraisal of a recent meta-analysis

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