Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia

Beneventi, Fausta; Locatelli, Elena; Amici, Mara De; Cavagnoli, Chiara; Bellingeri, Camilla; Maggio, Irene De; Ruspini, Beatrice; Spinillo, Arsenio

doi:10.1080/14767058.2019.1593359

Cited by 13 publications

(14 citation statements)

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“…Leptin is an adipokine expressed in adipose tissue, that is, involved in energy expenditure and the modulation of insulin resistance ( Thagaard et al, 2019b ). This hormone is also produced by trophoblastic cells of the placenta ( Beneventi et al, 2020 ). A recent study suggests that high preconceptual leptin levels may be a body mass index-independent risk factor for gestational diabetes mellitus and also a body mass index-dependent risk factor for hypertensive pregnant women ( Peltokorpi et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, placental production of leptin contributes to the increase in maternal leptin concentration during pregnancy ( Thagaard et al, 2019a ; Kaze et al, 2021 ; Bhat et al, 2022 ). Beneventi et al, 2020 investigated maternal and fetal plasma levels of leptin in pregnancies complicated by obesity and preeclampsia. The authors found that pregnant women with obesity had higher serum leptin levels than normal-weight subjects with and without hypertension or normotensive subjects with obesity ( Larsen et al, 2019 ; Beneventi et al, 2020 ; Abraham and Romani, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“… Beneventi et al, 2020 investigated maternal and fetal plasma levels of leptin in pregnancies complicated by obesity and preeclampsia. The authors found that pregnant women with obesity had higher serum leptin levels than normal-weight subjects with and without hypertension or normotensive subjects with obesity ( Larsen et al, 2019 ; Beneventi et al, 2020 ; Abraham and Romani, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

et al. 2022

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Background: Preeclampsia is a serious pregnancy complication that affects 5%–10% of the obstetric population.Objective: To study inflammatory markers associated with preeclampsia.Search Strategy: Searches of articles on the topic published over a 10-year period (2009–2019) were performed in three databases (PubMed, Cochrane, and Embase) using the keywords preeclampsia and inflammatory markers. The PubMed search using 10 years and humans as filters retrieved 124 articles. Using an advanced search strategy, 0 articles were identified in Embase and 10 articles in Cochrane. After screening and eligibility assessment, 13 articles were included in the systematic review and meta-analysis. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program.Results: For meta-analysis, women with preeclampsia were compared to control women, i.e., pregnancies without arterial hypertension. Leptin levels were significantly higher (p < 0.0002) in women with preeclampsia compared to controls. Total cholesterol was also significantly elevated in women with preeclampsia (p < 0.0001). There was no significant difference in HDL between groups, but women with preeclampsia had significantly increased LDL (p < 0.01). The same was observed for triglycerides, which were significantly increased in women with preeclampsia (p < 0.04) compared to controls. Analysis of TNF-alpha, an important inflammatory marker, showed higher levels in women with preeclampsia (p < 0.03) compared to controls. The same was observed for another important inflammatory marker, interleukin 6, which was significantly increased in women with preeclampsia (p < 0.0002). There was a significant increase of C-reactive protein in women with preeclampsia (p < 0.003) compared to controls.Conclusion: Women with preeclampsia have increased levels of inflammatory markers compared to control women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

et al. 2022

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“…Sementara itu hanya 60-70 % di negara rendah. Beneventi et al [17] Hasil analisis bivariat ini sejalan dengan penelitian Asmana, Syahredi, dan Hilbertina [18] Hal ini yang menimbulkan hasil yang rancu untuk membedakan preeklampsia dan hipertensi kronik dengan superimposed preeklampsia. Dengan tida tersedianya data tekanan darah sebelum kehamilan atau riwayat tekanan darah sebelumnya, maka hal ini juga akan menyebabkan kesalahan dari proses eksklusi sampel untuk pasien yang mempunyai riwayat hipertensi yang tidak diketahui [18] .…”

Section: Hubungan Indeks Masa Tubuh Pada Preeklampsiaunclassified

Hubungan Usia, Indeks Masa Tubuh, Dan Gravida Pada Ibu Hamil Dengan Preeklampsia Di Rumah Sakit Muhammadiyah Surabaya

rafida¹

2022

SBJ

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Preeclampsia is one of the causes of increased maternal mortality and morbidity, based on the Republic of Indonesia Ministry of Health data in 2016, the maternal mortality rate in East Java Province reached 91.00 per 100,000 live births. The highest cause of maternal death in 2016 was preeclampsia / eclampsia, which was 30.90% or as many as 165 people. Preeclampsia can appear at more than 20 weeks' gestation marked by hypertension and accompanied by proteinuria. This study aims to determine the relationship of age, body mass index, and gravida to pregnant women who have preeclampsia at Muhammadiyah Hospital in Surabaya. This type of research uses a cross sectional study, sample selection using total sampling with a minimum sample of 70 samples. Large samples obtained 210 respondents, as many as 105 experienced preeclampsia and 105 respondents did not experience preeclampsia. Based on the results of bivariate statistical tests found age is a risk factor for the incidence of preeclampsia (p: 0.039 <0.05), body mass index is associated with the incidence of preeclampsia (p: 0.002 <0.05) and gravida has no relationship with the incidence of preeclampsia (p: 0.410 > 0.05). Based on the multivariate test, there was an influence of age 36-45 years on the incidence of preeclampsia with a risk of 4.060 times experiencing preeclampsia compared to the age of 20-35 years, obese affected the incidence of preeclampsia with a risk of 4.696 times experiencing preeclampsia compared to normalweight and gravida influencing the incidence of preeclampsia with a risk of 2,099 times experiencing preeclampsia. The conclusion of this research is that there is a relationship between age, body mass index and gravida in preeclampsia at Muhammadiyah Hospital in Surabaya.

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“…For example, it is generally known that low folate levels increase the risk of neural tube defects in offspring, while first trimester inflammatory cytokines are associated with increased risk of preterm birth among obese women [31][32][33]. Furthermore, endocrine and inflammatory pathways are involved in the manifestation of obesity-related pregnancy complications such as GDM and preeclampsia [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Periconceptional biomarkers for maternal obesity: a systematic review

Hojeij

Rousian

Sinclair

et al. 2022

Rev Endocr Metab Disord

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Periconceptional maternal obesity is linked to adverse maternal and neonatal outcomes. Identifying periconceptional biomarkers of pathways affected by maternal obesity can unravel pathophysiologic mechanisms and identify individuals at risk of adverse clinical outcomes. The literature was systematically reviewed to identify periconceptional biomarkers of the endocrine, inflammatory and one-carbon metabolic pathways influenced by maternal obesity. A search was conducted in Embase, Ovid Medline All, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases, complemented by manual search in PubMed until December 31st, 2020. Eligible studies were those that measured biomarker(s) in relation to maternal obesity, overweight/obesity or body mass index (BMI) during the periconceptional period (14 weeks preconception until 14 weeks post conception). The ErasmusAGE score was used to assess the quality of included studies. Fifty-one articles were included that evaluated over 40 biomarkers. Endocrine biomarkers associated with maternal obesity included leptin, insulin, thyroid stimulating hormone, adiponectin, progesterone, free T4 and human chorionic gonadotropin. C-reactive protein was associated with obesity as part of the inflammatory pathway, while the associated one-carbon metabolism biomarkers were folate and vitamin B12. BMI was positively associated with leptin, C-reactive protein and insulin resistance, and negatively associated with Free T4, progesterone and human chorionic gonadotropin. Concerning the remaining studied biomarkers, strong conclusions could not be established due to limited or contradictory data. Future research should focus on determining the predictive value of the optimal set of biomarkers for their use in clinical settings. The most promising biomarkers include leptin, adiponectin, human chorionic gonadotropin, insulin, progesterone and CRP.

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Maternal and fetal Leptin and interleukin 33 concentrations in pregnancy complicated by obesity and preeclampsia

Cited by 13 publications

References 37 publications

Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

Hubungan Usia, Indeks Masa Tubuh, Dan Gravida Pada Ibu Hamil Dengan Preeklampsia Di Rumah Sakit Muhammadiyah Surabaya

Periconceptional biomarkers for maternal obesity: a systematic review

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