Maternal and fetal risk factors associated with severity of hypospadias: A comparison of mild and severe cases

Carlson, William H.; Kisely, Steve; MacLellan, Dawn L.

doi:10.1016/j.jpurol.2008.12.005

Cited by 31 publications

(29 citation statements)

References 24 publications

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“…In the present study prematurity and LBW were identified as significant risk factors, but after regression analysis, prematurity was found to be independently associated with hypospadias. Previous epidemiological studies have found a close relationship between hypospadias risk and LBW as well as preterm birth 6,9,28–30 . Carmichael et al .…”

Section: Discussionmentioning

confidence: 95%

“…Besides asking for meat consumption habits (whether it had been consumed at least once a week), five options were provided with regards to fish consumption: none, once a month, twice a month, once weekly, and a few times weekly 5 . The environmental risk factors included in the questionnaire were selected by means of a literature review 2,4,5,21,23,28,32 …”

Section: Methodsmentioning

confidence: 99%

“…Some studies further suggest that maternal intake of progestins during early pregnancy may be associated with an increased risk of hypospadias 4,24–26 . In many studies an association between low birthweight (LBW) and hypospadias has been found 6,9,27–30 . Pierik et al .…”

mentioning

confidence: 99%

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Hypospadias in Istanbul: Incidence and risk factors

Akın

Ercan

Telatar

et al. 2011

Pediatrics International

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Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

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Hypospadias in Istanbul: Incidence and risk factors

Akın

Ercan

Telatar

et al. 2011

Pediatrics International

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“…Although the incidence rate of hypospadias differs greatly by urologic center, studies by Carlson et al [5] reported an incidence rate of 1 per 125 newborn infants. A recent study that analyzed a huge pool of hypospadias patients reported that the incidence of hypospadias is increasing nowadays.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for the Development of Urethrocutaneous Fistula after Hypospadias Repair: A Retrospective Study

et al. 2012

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PurposeThe purpose of this study was to investigate the risk factors for urethrocutaneous fistula development after hypospadias repair.Materials and MethodsBetween January 1990 and May 2010, 348 patients underwent hypospadias repair. This study included 294 patients who were followed up for more than 6 months. Potential risk factors for the development of fistula after operation included age, location of hypospadias, type of hypospadias repair, suture materials and methods, methods and duration of catheterization, combined congenital urologic disorders, timing of presentation and repair of fistula, and location of fistula. Data were analyzed retrospectively. Binary logistic regression analysis was used for univariate and multivariate analysis.ResultsOut of 294 patients, 63 patients (21.4%, 63/294) developed urethrocutaneous fistulas after hypospadias repair. In the univariate analysis, fistula formation was statistically related with type of hypospadias and type of hypospadias repair. In the multivariate analysis with stratification by hypospadias site, however, only the location of hypospadias was a significant independent risk factor in urethrocutaneous fistula development after hypospadias repair (p<0.001).ConclusionsOur results suggest that the risk of developing urethrocutaneous fistula after hypospadias repair is associated with the location of hypospadias (more proximal-type hypospadias). Type of hypospadias repair, suture materials, suture techniques, and number of other combined urologic disorders were not related to the development of urethrocutaneous fistulas.

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“…Stoll et al in 1990 [69] found a direct relation between hypospadias and low placental weight whilst Fujimoto et al in 2008 [70] demonstrated an increased occurrence of placental infarction in extremely low birth weight infants with hypospadias. The association in LBW infants with hypospadias seems to be stronger for more posterior forms of hypospadias, with more posterior hypospadias also associated with more severe IUGR [38,57,67,71,72]. Nausea in early pregnancy implies a good HCG surge [73].…”

Section: Pregnancy Relatedmentioning

confidence: 99%

Genetic and environmental factors in the aetiology of hypospadias

et al. 2015

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This article reviews the current evidence and knowledge of the aetiology of hypospadias. Hypospadias remains a fascinating anomaly of the male phallus. It may be an isolated occurrence or part of a syndrome or field defect. The increasing use of assisted reproductive techniques and hormonal manipulation during pregnancy may have been associated with an apparent rise in the incidence of hypospadias. Genetic studies and gene analysis have suggested some defects that could result in hypospadias. New light has also been thrown on environmental factors that could modulate candidate genes, causing altered development of the male external genitalia.

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Maternal and fetal risk factors associated with severity of hypospadias: A comparison of mild and severe cases

Cited by 31 publications

References 24 publications

Hypospadias in Istanbul: Incidence and risk factors

Hypospadias in Istanbul: Incidence and risk factors

Risk Factors for the Development of Urethrocutaneous Fistula after Hypospadias Repair: A Retrospective Study

Genetic and environmental factors in the aetiology of hypospadias

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