Maternal and infant serum carotenoids are associated with infantile atopic dermatitis development

Inoue, Yuzaburo; Yamamoto, Yu; Suzuki, Shigenori; Ochiai, Satoru; Eguchi, Akifumi; Nakano, Taiji; Yamaide, Fumiya; Hasegawa, Satomi; Kojima, Hiroyuki; Mori, Chisato; Kohno, Yoichi; Suganuma, Hiroyuki; Shimojo, Naoki

doi:10.1111/all.15730

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Maternal consumption of vegetables during pregnancy has also been associated with a lower likelihood of eczema and asthma ( 120 ). A prospective study by Inoue et al on a cohort of 267 infants with a family history of allergy found that certain levels of carotenoids, such as lutein and lycopene, were associated with a reduced likelihood of developing AD at 1 year of age ( p < 0.001) ( 42 ). Moreover, in a pediatric study, the correlation between vitamin A and D deficiency and the severity AD was assessed.…”

Section: Antioxidant Agentsmentioning

confidence: 99%

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

De Simoni,

Candelora,

Belleggia

et al. 2024

Front. Nutr.

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, epidermal barrier dysfunction, and an unbalanced inflammatory reaction. AD pathophysiology involves a dysregulated immune response driven by T helper-2 cells. Many factors, including reactive oxygen species (ROS), are involved in AD pathogenesis by causing cellular damage and inflammation resulting in skin barrier dysfunction. This narrative review aims to provide a comprehensive overview of the role of natural molecules and antioxidant compounds, highlighting their potential therapeutic value in AD prevention and management. They include vitamin D, vitamin E, pyridoxine, Vitamin C, carotenoids, and melatonin. Some studies report a statistically significant association between antioxidant levels and improvement in AD, however, there are conflicting results in which antioxidant supplementation, especially Vitamin D, did not result in improvement in AD. Therefore, the clinical efficacy of these dietary nutritional factors in the treatment of AD needs to be further evaluated in clinical trials. Meanwhile, antioxidants can be incorporated into the management of AD patients in a personalized manner, tailored to the severity of the disease, comorbidities, and individual needs.

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Section: Antioxidant Agentsmentioning

confidence: 99%

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

De Simoni,

Candelora,

Belleggia

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Maternal consumption of vegetables during pregnancy has also been associated with a lower likelihood of eczema and asthma [100]. A prospective study by Inoue et al on a cohort of 267 infants with a family history of allergy found that certain levels of carotenoids, such as lutein and lycopene, were associated with a reduced likelihood of developing atopic dermatitis at one year of age (p<0.001) [101].…”

Section: Carotenoidsmentioning

confidence: 99%

Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis

Simoni¹,

Candelora²,

Belleggia³

et al. 2023

Preprint

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, impaired epidermal barrier function and unbalanced inflammatory response. The pathophysiology involves immune dysregulation, with a predominance of T-helper 2 cells. AD is triggered by many known and unknown factors, including oxidative stress. Reactive oxygen species (ROS) contribute to AD pathogenesis by causing cellular damage and inflammation. Moreover, increased oxidative stress in AD leads to hyperactivation of the MAP kinase pathway, extracellular signal-regulated kinase (ERK) and p38, with DNA damage and subsequent skin barrier dysfunction. This narrative review provides a comprehensive overview of the role of natural antioxidant compounds, highlighting their potential therapeutic value in AD management. They include vitamin D, vitamin E, pyridoxine (vitamin B6), Vitamin C, carotenoids and melatonin, in AD. Despite some studies have shown an association between vitamin D, vitamin E, vitamin C and carotenoids levels and AD course, conflicting results exist. Pyridoxine supplementation has shown mixed results, and melatonin has demonstrated antioxidant and anti-inflammatory properties in AD; in fact, melatonin treatment resulted in a decrease in symptoms in patients with AD, although no significant correlation with changes in sleep latency was reported. In addition, iron and zinc (Zn) supplementation can also improve AD symptoms. Further research is needed to elucidate the optimal use of these natural antioxidants in AD treatment

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Maternal and infant serum carotenoids are associated with infantile atopic dermatitis development

Cited by 2 publications

References 6 publications

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis

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