Maternal and Neonatal Evaluation of Derived Reactive Oxygen Metabolites and Biological Antioxidant Potential in Donkey Mares and Foals

Sgorbini, Micaela; Bonelli, Francesca; Percacini, Giulia; Pasquini, Anna; Rota, Alessandra

doi:10.3390/ani11102885

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…Vakilian et al [65], comparing both modes of delivery using thiobarbituric reactive substances (TBARS) as markers of lipid peroxidation, total antioxidant power (TAP), and total thiol molecules (TTM) in the blood of mothers and their newborns, showed that natural childbirth causes an increase in OS compared to cesarean section. Sgorbini et al [66] showed the same relationship when studying reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), noting the effective antioxidant defense of newborns, who often coped with ROS better than their mothers.…”

Section: Oxidative Stressmentioning

confidence: 83%

Oxidative Stress in Pregnancy

Grzeszczak,

Łanocha-Arendarczyk,

Malinowski

et al. 2023

Preprint

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Recent years have seen an increased interest in the role of oxidative stress (OS) in pregnancy. Pregnancy inherently heightens susceptibility to OS, a condition fueled by a systemic inflam-matory response which culminates in an elevated presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the circulatory system. The amplified OS in pregnancy can trigger a series of detrimental outcomes such as underdevelopment, abnormal placental function, and a host of pregnancy complications, including pre-eclampsia, embryonic resorp-tion, recurrent pregnancy loss, fetal developmental anomalies, intrauterine growth restriction, and in extreme instances, fetal death. The body’s response to mitigate the uncontrolled increase in RNS/ROS levels involves trace elements that take part in non-enzymatic and enzymatic defense mechanisms, namely, copper (Cu), zinc (Zn), manganese (Mn), iron (Fe), and selenium (Se). Determination of ROS concentrations poses a challenge due to their short lifespan, prompting the use of marker proteins, including malondialdehyde (MDA), superoxide dis-mutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), lipid peroxidation (LPO), catalase (CAT), and glutathione (GSH). These markers, indicative of redox stress intensity, can offer indirect assessments of pregnancy complications. Given the limitations in conducting experimental studies on pregnant women, animal models serve as valuable substitutes for in-depth research. This review delves into the mechanism of OS in pregnancy and underscores the pivotal role of markers in its evaluation.

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Section: Oxidative Stressmentioning

confidence: 83%

Oxidative Stress in Pregnancy

Grzeszczak,

Łanocha-Arendarczyk,

Malinowski

et al. 2023

Preprint

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show abstract

“…In fact, the tissue damage during the peripartum period may lead to an inflammatory response. Furthermore, the progressive increment of metabolic activity during pregnancy may induce an oxidative stress status in animals, linked to inflammation [51]. The ADA is a ω-6 that can further predispose animals to oxidative stress though an influence on antioxidant system expression, such as superoxide dismutase (SOD) and glutathione peroxidase (Gpx) [52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Differences of the Plasma Total Lipid Fraction from Pre-Foaling to Post-Foaling Period in Donkeys

Lisuzzo

Bonelli

Sgorbini

et al. 2022

Animals

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The period from late gestation to early lactation is characterized by changes in energy metabolism. The aim of the current study was to analyze the plasma total lipid fraction using gas chromatography (GC) analysis, in order to highlight metabolic changes from the pre-foaling to post-foaling periods. Eleven pluriparous dairy jennies (mean age of 11.88 ± 3.79 years) belonging to the Amiata donkey breed were enrolled. Blood sampling was performed at 15 days before foaling (T0), and 15 (T1), 30 (T2), 60 (T3), and 90 (T4) days after foaling, for biochemical and GC analysis. A total of 37 fatty acids were identified in plasma samples: 4 medium chain (MCFA), 24 long chain (LCFA), and 9 very-long chain (VLCFA) fatty acids. Among them, 20 fatty acids changed significantly, and two fatty acid showed a trend toward significance. Furthermore, the LCFA, saturated, unsaturated, monounsaturated, and polyunsaturated ω-3 fatty acids changed significantly during the study period. The main alterations were between T0 and the other time points and appeared to be related to lipid metabolism, cellular structure and function, and inflammatory and immune responses. Our findings reveal greater energy requirements at the end of gestation compared to early lactation in donkeys.

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“…Among these, donkey farming is becoming more popular due to donkey milk being used as an alternative to cow’s milk for children’s intolerances and in the cosmetic industry due to its organoleptic properties [ 2 , 3 ]. With the increasing interest in donkeys as dairy animals, studies concerning their health and welfare have been raised [ 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Ultrasound Measurement of Subcutaneous Fat Thickness in Dairy Jennies during the Periparturient Period

Nocera

Bonelli

Turini

et al. 2022

Animals

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The body condition score (BCS) represents a practical but subjective method for assessing body fat reserves. Real time ultrasonography (RTU) has been proposed as an accurate method to objectively measure subcutaneous fat (SF) thickness and predict body fat reserves in cows, horses and donkeys. The aim of the present study was to describe RTU measures of SF thickness during periparturient period in jennies. The present prospective cohort study evaluated six dairy jennies. SF RTU were performed at 15 and 7 days before the presumptive delivery, and 2, 15 and 30 days after delivery. A portable ultrasound machine and multifrequency linear transducer (5–7.5 MHz) was used. RTU images were obtained in six sites (S1–S6). Results at each time point were reported as mean ± standard deviation and compared through time. A total of 180 images were evaluated. RTU technique was easy to perform and well tolerated. No statistically significant differences were found of each site during time, except for S2 and S6a: S2 at T2 and S6a at T1 were significatively different to values obtained at T5. The RTU mean values were above those reported by others, suggesting major physio-logical challenges related to energy balance and fat mobilization in pregnant jennies bred for milking production. BCS and sites through observational time have shown a good and reliable association. Our study could give preliminary indications on fat reserves in different body locations evaluated thanks to RTU and it show no significative variation of SF thickness, in pregnant and lactating jennies.

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Maternal and Neonatal Evaluation of Derived Reactive Oxygen Metabolites and Biological Antioxidant Potential in Donkey Mares and Foals

Cited by 6 publications

References 56 publications

Oxidative Stress in Pregnancy

Oxidative Stress in Pregnancy

Differences of the Plasma Total Lipid Fraction from Pre-Foaling to Post-Foaling Period in Donkeys

Evaluation of Ultrasound Measurement of Subcutaneous Fat Thickness in Dairy Jennies during the Periparturient Period

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