Maternal and neonatal outcomes following <i>in vitro</i> fertilization: A cohort study in Romania

Bănică, Andreea Mădălina; Popescu, Simona; Vlădăreanu, Simona

doi:10.3892/etm.2021.10956

Cited by 4 publications

(9 citation statements)

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“…We did find a higher prevalence of prematurity, multiplicity, and low birth weight among neonates conceived through ART, which is consistent with other studies . However, to our knowledge, no study has been specifically designed to explore the perinatal outcomes of neonates conceived through ART compared with naturally conceived neonates in the NICU setting.…”

Section: Discussionsupporting

confidence: 91%

“…We did find a higher prevalence of prematurity, multiplicity, and low birth weight among neonates conceived through ART, which is consistent with other studies. 14 , 28 , 29 However, to our knowledge, no study has been specifically designed to explore the perinatal outcomes of neonates conceived through ART compared with naturally conceived neonates in the NICU setting. In addition, the association of preterm birth, multiple births, and low birth weight with genetic causes among neonates conceived though ART remains unclear and requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Genetic Profiles of Neonates in Intensive Care Units Conceived With or Without Assisted Reproductive Technology

Huang

Xiao

et al. 2023

JAMA Netw Open

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ImportanceA growing number of children are conceived with assisted reproductive technology (ART). However, there is a lack of studies systematically analyzing the genetic landscape of live-born children conceived through ART who need intensive care in the neonatal period.ObjectiveTo investigate the incidence and type of molecular defects among neonates conceived through ART who are in intensive care units (NICUs) with suspected genetic conditions.Design, Setting, and ParticipantsThis was a cross-sectional study using data from the China Neonatal Genomes Project, a multicenter national neonatal genome data set managed by the Children’s Hospital of Fudan University. All participants were from level III and IV NICUs and included 535 neonates conceived through ART with suspected genetic conditions, with data collected between August 1, 2016, and December 31, 2021, and 1316 naturally conceived neonates with suspected genetic conditions in the same clinical settings, with data collected between August 1, 2016, and December 31, 2018. The data were analyzed between September 2021 and January 2023.ExposuresWhole-exome sequencing or target clinical exome sequencing with pathogenic or likely pathogenic single-nucleotide variant (SNV) and copy number variation (CNV) detection was performed for each individual.Main Outcomes and MeasuresThe primary outcome was the molecular diagnostic yield, mode of inheritance, spectrum of genetic events, and incidence of de novo variants.ResultsA total of 535 neonates conceived through ART (319 boys [59.6%]) and 1316 naturally conceived neonates (772 boys [58.7%]) were included. A genetic diagnosis was established for 54 patients conceived through ART (10.1%), including 34 patients with SNVs (63.0%) and 20 with CNVs (37.0%). In the non-ART group, 174 patients (13.2%) received a genetic diagnosis, including 120 patients with SNVs (69.0%) and 54 with CNVs (31.0%). The overall diagnostic yield was comparable between the ART group and the naturally conceived neonates (10.1% vs 13.2%; odds ratio [OR], 0.74; 95% CI, 0.53-1.02), as was the proportion of SNVs (63.0% vs 69.0%; OR, 0.68; 95% CI, 0.46-1.00) and CNVs (37.0% vs 31.0%; OR, 0.91; 95% CI, 0.54-1.53) detected by sequencing. Furthermore, the proportions of de novo variants in the ART group and the non-ART group were similar (75.9% [41 of 54] vs 64.4% [112 of 174]; OR, 0.89; 95% CI, 0.62-1.30).Conclusions and RelevanceThis cross-sectional study of neonates in NICUs suggests that the overall genetic diagnostic yield and the incidence of de novo variants were similar between live-born neonates conceived through ART and naturally conceived neonates in the same settings.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of Genetic Profiles of Neonates in Intensive Care Units Conceived With or Without Assisted Reproductive Technology

Huang

Xiao

et al. 2023

JAMA Netw Open

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“…According to a study conducted in Romania, neonates derived from IVF had a significantly higher risk of prematurity (OR = 6.52), low birth weight (OR = 17.18), small for gestational age (OR = 4.10), and were more frequently hospitalized in the neonatal intensive care unit (OR = 11.91) than neonates obtained spontaneously [54]. No OHSS, CHM-related side effects on female reproductive systems were reported in our study group, and the rate of multiple deliveries was 0%.…”

Section: Discussionmentioning

confidence: 99%

“…Most IVF-conceived babies are healthy, but IVF has also been related to adverse perinatal outcomes such as preterm birth, low birth weight, small for gestational age, large for gestational age, and congenital anomalies [52, 53]. According to a study conducted in Romania, neonates derived from IVF had a significantly higher risk of prematurity (OR = 6.52), low birth weight (OR = 17.18), small for gestational age (OR = 4.10), and were more frequently hospitalized in the neonatal intensive care unit (OR = 11.91) than neonates obtained spontaneously [54]. No OHSS, CHM-related side effects on female reproductive systems were reported in our study group, and the rate of multiple deliveries was 0%.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Effects of Chinese Herbal Medicine in the Management of Female Infertility: A Hospital-Based Study

Chou,

Chen,

Wang

et al. 2023

Complement Med Res

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Background In Taiwan, Chinese herbal medicine(CHM) is used to treat female infertility. Evidence indicates that the absence of monotherapy efficacy assessment and comparison with mainstream interventions may lead to the improper use of CHM for female infertility. Methods A retrospective cohort study enrolled female patients at a hospital undergoing CHM intervention to treat infertility from 2012 to 2020 in order to determine the outcomes of CHM monotherapy for female infertility. Kaplan–Meier analysis under strict assumptions was used to estimate the cumulative probability of pregnancy and live births after CHM. Cox hazard regression analysis was used to estimate the hazard ratios of prognostic variables, namely the woman’s age and diagnostic category. Results 694 women met the inclusion criteria and accounted for 2,145 cycles. A total of 190 pregnancies resulted in 125 live births, all of which were singleton births of babies with 16 perinatal complications requiring hospitalization. The real cumulative pregnancy rate and cumulative live birth rate(CLBR) for the total population after 10 cycles were between 27.4% and 35.2% and between 18% and 22.1%, respectively. Compared with the live birth rate corresponding to patients aged under 35 years, that of older patients, particularly those aged 38 to 39 years, was significantly lower (hazard ratio: 0.19, 95% confidence interval: 0.11–0.33). Women with other diagnoses, namely uterine problems or endometriosis, had a greater probability of a live birth than did women with tubal pathology (hazard ratio: 6.31, 95% confidence interval: 1.99–20.07). Conclusion To the best of our knowledge, this is the first retrospective study to employ life table analysis to determine the CHM treatment outcomes in terms of female infertility. The study established a basis to compare in vitro fertilization(IVF) with CHM and identified the advantages and disadvantages of CHM for treating female infertility. Although the CLBR of present study is lower than those reported in IVF studies, CHM in treating female infertility can still be beneficial to women aged younger than 38 years or with diagnoses other than tubal pathology and worth recommendation by reproductive specialists according to the promising results gained from the strict criteria. However, in order to determine the optimal timing, possible mechanism, corresponding side effects and the efficacy of CHM combined with IVF for treating female infertility, rigorous research is required.

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“…Bănică et al . [ 16 ] reported that IVF pregnancy in women was associated with a higher risk of maternal and neonatal complications compared to spontaneous pregnancies. The finding of another study also indicated that IVF is associated with the incidence of preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Comparing the occurrence rate of gestational hypertension during pregnancy with frozen embryo transfer and natural pregnancy

Moramezi,

Nikbakht,

Saadati

et al. 2023

Journal of Family Medicine and Primary Care

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Introduction: Recent researches have indicated that pregnancies with frozen embryo transfer are associated with the increment of risk of maternal and neonatal complications, especially hypertension during pregnancy. The present study aimed to compare the occurrence rate of gestational hypertension in pregnancy with frozen embryo transfer and normal pregnancy. Materials and Methods: This research, as a retrospective cross-sectional study, was performed on pregnant women with frozen embryo transfer (n = 97) and women with normal pregnancies (n = 164) referring to medical centers under the supervision of Ahvaz University of Medical Sciences in 2021. Women aged 18–35 were included in the study after week 20th of pregnancy. Maternal and neonatal outcomes including hypertensive disorders of pregnancy (including gestational hypertension and preeclampsia), preterm birth (before the week 37th), low birth weight (lower than 2500 g), neonatal asphyxia (Apgar score >7 in minute 5th), intrauterine growth restriction (IUGR) and bleeding in the first trimester of pregnancy were evaluated. The association between frozen embryo transfer and pregnancy outcomes was evaluated using multiple logistic regressions. Results: The findings of this study indicated that pregnancy hypertension was observed in 23 people (23.7%) from the frozen embryo transfer group vs. 18 people (11.0%) from the normal pregnancy group (P = 0.006). Frozen embryo transfer pregnancy has a higher risk of gestational hypertension (OR = 2.521, 95% CI: 1.281-4.962; P = 0.007), preterm birth (OR = 2.264, 95% CI: 1.335-3.840; P = 0.002), and low birth weight (OR = 2.017, 95% CI: 1.178-3.455; P = 0.011). However, the incidence of birth asphyxia (P = 0.850), intrauterine growth restriction (P = 0.068), first-trimester bleeding (P = 0.809), and placenta accreta (P = 0.143) did not show a significant difference between two types of normal pregnancy and frozen embryo transfer pregnancy. Conclusion: Frozen embryo transfer pregnancy was associated with a higher risk of maternal and neonatal complications, hypertension, preterm birth, and low birth weight compared to natural and spontaneous pregnancies.

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Maternal and neonatal outcomes following in vitro fertilization: A cohort study in Romania

Cited by 4 publications

References 40 publications

Comparison of Genetic Profiles of Neonates in Intensive Care Units Conceived With or Without Assisted Reproductive Technology

Comparison of Genetic Profiles of Neonates in Intensive Care Units Conceived With or Without Assisted Reproductive Technology

Characteristics and Effects of Chinese Herbal Medicine in the Management of Female Infertility: A Hospital-Based Study

Comparing the occurrence rate of gestational hypertension during pregnancy with frozen embryo transfer and natural pregnancy

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