Maternal and Neonatal Outcomes in Women with Preeclampsia

Saadat, Mandana; Nejad, S.M Aghaee; Habibi, Gholamreza; Sheikhvatan, Mehrdad

doi:10.1016/s1028-4559(08)60029-7

Cited by 53 publications

(47 citation statements)

References 16 publications

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“…It is defined by the onset of hypertension (140/90 mm HG) after 20 weeks’ gestation in the index pregnancy, accompanied by 300 mg of protein in a 24-h urine specimen, or persistent >30 mg/dL (1+) protein on a dipstick [2, 4]. While the etiology of preeclampsia is still elusive, it remains a leading cause of mortality and morbidity among mothers and their babies [4–6]. …”

Section: Preeclampsia Genomic Imprinting and Child Neurobehavioral mentioning

confidence: 99%

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

Nomura

Roshan

Janssen

et al. 2017

Arch Gynecol Obstet

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Purpose Preeclampsia is known to be a leading cause of mortality and morbidity among mothers and their infants. Approximately 3–8% of all pregnancies in the US are complicated by preeclampsia and another 5–7% by hypertensive symptoms. However, less is known about its long-term influence on infant neurobehavioral development. The current review attempts to demonstrate new evidence for imprinting gene dysregulation caused by hypertension, which may explain the link between maternal preeclampsia and neurocognitive dysregulation in offspring. Method Pub Med and Web of Science databases were searched using the terms “preeclampsia,” “gestational hypertension,” “imprinting genes,” “imprinting dysregulation,” and “epigenetic modification,” in order to review the evidence demonstrating associations between preeclampsia and suboptimal child neurodevelopment, and suggest dysregulation of placental genomic imprinting as a potential underlying mechanism. Results The high mortality and morbidity among mothers and fetuses due to preeclampsia is well known, but there is little research on the long-term biological consequences of preeclampsia and resulting hypoxia on the fetal/child neurodevelopment. In the past decade, accumulating evidence from studies that transcend disciplinary boundaries have begun to show that imprinted genes expressed in the placenta might hold clues for a link between preeclampsia and impaired cognitive neurodevelopment. A sudden onset of maternal hypertension detected by the placenta may result in misguided biological programming of the fetus via changes in the epigenome, resulting in suboptimal infant development. Conclusion Furthering our understanding of the molecular and cellular mechanisms through which neurodevelopmental trajectories of the fetus/infant are affected by preeclampsia and hypertension will represent an important first step toward preventing adverse neurodevelopment in infants.

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Section: Preeclampsia Genomic Imprinting and Child Neurobehavioral mentioning

confidence: 99%

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

Nomura

Roshan

Janssen

et al. 2017

Arch Gynecol Obstet

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“…In the United States among 2,748,302 births in 2008, there were 104,850 cases of preeclampsia (Osterman, Martin, Mathews, & Hamilton, 2011). While the etiology of preeclampsia is currently elusive, it remains a leading cause of mortality and morbidity among mothers and their babies (Podymow & August, 2007; Chang et al, 2003; Saadat, Nejad, Habibi, & Sheikhvatan, 2007). …”

Section: Introductionmentioning

confidence: 99%

“…The main impact of preeclampsia to the fetus is under-nutrition, resulting from utero-placental vascular insufficiency hypoxia, which restricts nutrient supplies and oxygen flow from the placenta to the fetus (Kajantie, Thornburg, Eriksson, Osmond, & Barker, 2010). This leads to various perinatal and neonatal problems, including intra-uterine growth restriction (IUGR, defined as birth weight less than the 10th percentile) (Saadat et al, 2007; Kajantie et al, 2010; Liu, Cheng, & Chang, 2008; Rasmussen & Irgens, 2003; Powe et al, 2011; Odegard, Vatten, Nilsen, Salvesen, & Austgulen, 2000; Jelin, Cheng, Shaffer, Kaimal, Little, & Caughey, 2010; Habli, Levine, Qian, & Sibai, 2007) emergency C-section (Saadat et al, 2007), preterm delivery (Rasmussen & Irgens, 2003; Liggins & Howie, 1972; Bramham, Briley, Seed, Poston, Shennan, & Chappell, 2011), reduced birth weight (Saadat et al, 2007; Edwards, Benediktsson, Lindsay, & Seckl, 1993; Benediktsson, Lindsay, Noble, Seckl, & Edwards, 1993), more frequent and prolonged NICU (neonatal intensive care unit) stay (Saadat et al, 2007; Habli et al, 2007; Masoura et al, 2012), and increased acute respiratory distress syndromes after birth (Habli et al, 2007; Kalder, Ulrich, Hitschold, & Berle, 1995). In some cases, fetal damage is so severe that it results in fetal/child mortality such as fetal demise, still-birth, and neonatal death (Jones, Bell, & Maroof, 1999).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Preeclampsia on Perinatal Risks and Infant Temperaments Among Mothers With Antenatal Depression

Nomura

Finik

Salzbank

et al. 2014

JPR

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Importance Preeclampsia and depression are two most prevalent disorders known to affect pregnant women and unborn infant. However, few studies have prospectively examined the adverse influence of the in-utero exposures to the two disorders on the optimal development in their offspring, including mortality, adverse birth outcomes, and infant temperament styles. Objectives (1) To examine whether exposures to preeclampsia and antenatal depression were associated with developmental indices of offspring at birth and temperament at 3 months; and (2) To evaluate how preeclampsia and antenatal depression associated with offspring temperamental style. Design Prospective cohort study with regular assessment of mother’s blood pressure at each prenatal visit: offspring were followed till 3 months. Setting Two prenatal clinics, New York City, USA. Participants A cohort of 233 pregnant women was followed throughout pregnancy. Of those, 141 provided ratings of infant temperament at three months. Exposures Diagnostic outcome of maternal depression by clinical interviewers blind to preeclampsia status, were ascertained using the Structured Clinical Interview for DSM-IV Axis I Disorders. The development of preeclampsia, defined by the onset of hypertension (> 140/90 mm HG) after 20 weeks’ gestation, accompanied by 300 mg of protein, monitored via electronic medical records. Main Outcome Measures Birth outcomes were assessed via standardized ratings at delivery. Infant temperament was reported by the mother at three months, using 91-item IBQ-R (Infant Behavioral Questionnaire-Revised). Results Preeclampsia was associated with an over 5-fold increased risk for fetal/infant mortality, a 3- to 7-fold increased risk for poorer birth outcomes, and flatter affect and distress in infants. Furthermore, infants born to preeclamptic mothers with co-occurring depression displayed lower levels of smile/laughter, high-intensity pleasure seeking behavior, perceptual sensitivity, and approach behavior. Conclusion Preeclampsia was associated with a few difficult temperament styles in the first three months after birth. Moreover, its negative impact was amplified by mother’s antenatal depression. Our findings regarding additive risk for negative infant outcomes in babies exposed to preeclampsia and antenatal depression suggests that the development of early detection programs to identify and monitor women who are at heightened risk for these conditions can potentially have a positive influence on long-term infant neurobehavioral development.

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“…5 In a study conducted by Baha M Sibai et al 11 in 1984 on 303 preeclampsia women, abruptio placentaee was noted in 5.6% women. In a study conducted by Mandana Saadat et al 12 studied 125 women with PE and they were matched with the control group, i.e. 125 normotensive women.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Abruptio Placentae in Preeclampsia in a Rural Tertiary Care Hospital

Bulusu¹,

Ray²,

Maji³

2016

jebmh

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BACKGROUNDPreeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks of gestational age. It occurs in 3-5% of pregnancies and is still a major cause of both foetal and maternal morbidity and mortality worldwide. One of the most serious and dreaded complication of preeclampsia is abruptio placentae. Placental separation from its implantation site before delivery of the foetus has been called abruption placentae or accidental haemorrhage. Various studies have shown that there is 2-2.5 fold increase in incidence of abruption in hypertensive disorder of pregnancy.The aim of the study is to study the incidence of abruptio placentae in women with preeclampsia.

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Maternal and Neonatal Outcomes in Women with Preeclampsia

Abstract: Gestational age, parity, cesarean section rate, the rate of induced labor, and low birth weight neonates were more frequent in preeclamptic women than in healthy pregnant women.

Cited by 53 publications

References 16 publications

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

The Effects of Preeclampsia on Perinatal Risks and Infant Temperaments Among Mothers With Antenatal Depression

Incidence of Abruptio Placentae in Preeclampsia in a Rural Tertiary Care Hospital

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