Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature

Wong-Taylor, Li-An; Lawrence, Alexandra; Cowen, Sophie; Jones, Hetty; Nauta, Maud; Ramsay-Marcelle, Zeudi; Yoong, Wai

doi:10.1007/s00404-012-2219-4

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…Our study showed that mothers with maternal age ≥36 years were more likely to deliver preterm babies. It is consistent with the previous studies [37,38] . Previous evidence showed that the risk of pregnancy outcome would be greater in advanced age due to placental physiological changes of aging [37,39] .…”

Section: Discussionsupporting

confidence: 94%

Risk Factors for Adverse Pregnancy Outcomes among Zhuang Ethnic Pregnant Women: A Cohort Study in Guangxi, China

et al. 2021

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SummaryRisk factors for adverse pregnancy outcomes among Zhuang ethnic pregnant women are unclear. This study analyzed the incidence and risk factors related to preterm birth (PB), low birth weight (LBW) and macrosomia in Zhuang population. We conducted a prospective cohort study of 9965 Zhuang pregnancy women in Guangxi, China. Information on mothers and newborns was obtained by using questionnaires and referring to medical records. Multivariate logistic regression analyses were used to evaluate the association between related factors and adverse pregnancy outcomes. Our results showed that the incidence of PB, LBW and macrosomia in Zhuang people was 5.55%, 5.64% and 2.19%, respectively. Maternal age ≥36 years (OR=2.22, 95% CI: 1.51–3.27) was related to a higher incidence of PB. Those with pre-pregnancy body mass index (BMI) <18.5 kg/m2 (OR=1.91, 95% CI: 1.45–2.51), and had a female fetus (OR=1.74, 95% CI: 1.36–2.23) were more likely to have LBW infants. Maternal age between 31 and 35 years (OR=1.76, 95% CI: 1.03–2.99) and pre-pregnancy overweight or obesity (OR=1.79, 95% CI: 1.15–2.80) were associated with a higher risk of macrosomia. The protective factors of macrosomia were maternal pre-pregnancy BMI <18.5 kg/m2 (OR=0.30, 95% CI: 0.15–0.60) and female fetus (OR=0.41, 95% CI: 0.28–0.59). Our study provided a reference for maternal and childcare administration among Zhuang population.

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Section: Discussionsupporting

confidence: 94%

Risk Factors for Adverse Pregnancy Outcomes among Zhuang Ethnic Pregnant Women: A Cohort Study in Guangxi, China

et al. 2021

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“…9 This postponement is associated not only with epigenetic changes in offspring related to DOHaD, but also with decreased fertility in both males and females, as well as adverse pregnancy outcomes in women. 10,11 The trend toward greater postponement of childbearing highlights the importance of researching the effects of parental age on DOHaD. Researchers are increasingly turning to large animal models, because of several advantages.…”

Section: Introductionmentioning

confidence: 99%

“…If this association between DOHaD and parental age is true, it is likely to worsen, as modern living is associated with postponement of childbearing 9 . This postponement is associated not only with epigenetic changes in offspring related to DOHaD, but also with decreased fertility in both males and females, as well as adverse pregnancy outcomes in women 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Maternal aging affects life performance of progeny in a Holstein dairy cow model

Astiz

González-Bulnes

Sebastián

et al. 2014

J Dev Orig Health Dis

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The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently high-yielding (PHY) cows, which accounted for 33% of the animals; medium-yielding (MY) cows, 41%; and low-yielding (LY) cows, 26%. Prenatal determinants of the life performance of the progeny were analyzed. Developmental and environmental factors were excluded as determinants of performance (including birth weight, level of passive immunity transfer, growth rate, age at first parturition and reproductive efficiency). Life performance did show minor seasonal effects, with more HY cows but less PHY being born during the cold season (90.1% in HY; 58.3% in PHY v. 81.5%). Instead, the single most important factor influencing life performance of daughters was maternal age. HY cows were born from the youngest mothers (1.89±1.14 parturitions, 3.12±1.42-year old), whereas LY cows were born from the oldest (2.72±1.80 parturitions, 3.97±2.01-year old; P<0.001). Life performance of the dams did not differ among clusters. In addition, metabolic parameters (fat and protein yield) were found to correlate significantly with yields between the first and second lactations (milk yield: r=0.357; fat yield: r=0.211; protein yield: r=0.277; P<0.0001), suggesting the influence of the individual. These results suggest that under optimal health, nutritional and environmental conditions, maternal aging is an important determinant of the life performance of progeny and argue for the need to identify conditions that contribute to health and disease in progeny according to the Developmental Origin of Health and Disease or DOHaD concept. Our findings may help the development of novel management guidelines for dairy farms.

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“…Kırk yaş üstü gebelikler çok ileri maternal yaş gebelikleri olarak adlandırılmaktadır. İleri maternal yaş gebelikleri gestasyonel diyabet, postpartum kanama ve preterm doğum gibi olumsuz obstetrik sonuçlara neden olabilmektedir (3,4) .…”

Section: Introductionunclassified

Effect of parity on obstetric outcomes in advanced maternal age pregnancies

Çetin¹,

Köroğlu²,

Bahat³

et al. 2017

Okmeydani Medical Journal

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Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature

Abstract: Pooled retrospective data suggest that women who conceived spontaneously after the age of 45 years have increased maternal morbidity and rates of caesarean section, as well as higher incidence of premature births and admission to special care baby unit.

Cited by 13 publications

References 26 publications

Risk Factors for Adverse Pregnancy Outcomes among Zhuang Ethnic Pregnant Women: A Cohort Study in Guangxi, China

Risk Factors for Adverse Pregnancy Outcomes among Zhuang Ethnic Pregnant Women: A Cohort Study in Guangxi, China

Maternal aging affects life performance of progeny in a Holstein dairy cow model

Effect of parity on obstetric outcomes in advanced maternal age pregnancies

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