Maternal and Neonatal Outcomes of Preterm Premature Rupture of Membranes before Viability

Marel, I. van der; Jonge, Rcj de; Duvekot, Johannes J.; Brussé, Ingrid A.

doi:10.1055/s-0041-111174

Cited by 21 publications

(30 citation statements)

References 28 publications

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“…Of these, 38 were selected for full text article review. Finally, 18 articles [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] were included in the review. Figure 1 shows the whole process of study selection, using PRISMA flow diagram [26].…”

Section: Resultsmentioning

confidence: 99%

“…Most of the included studies showed that the survival to discharge rate improved significantly with increasing GA at PPROM [14,15,[17][18][19]25]. van der Marel et al [14] reportedthat the neonatal survival was significantly better for PPROM at >20 weeks than at <20 Weeks(46.9 vs. 22.7 %, p=0.008). This association remained significant after adjusting for potential confounders (adjusted OR: 9.78, 95% CI: 1.85-51.66).…”

Section: Neonatal Survival To Dischargementioning

confidence: 99%

“…Overall, 21.6% (234/1083) of pre-viable PPROM women opted for TOP (Table 4). The decision to choose TOP was influenced by: GA at PPROM [12,14,18,25], AFI levels [12,17,23], and iatrogenic etiology of PPROM [18,23].…”

Section: Termination Of Pregnancymentioning

confidence: 99%

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Perinatal Outcomes of Pre-viable Preterm Premature Rupture of Membranes

Mukhtar¹

2018

J Gyn Obs Bul

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Objective: To assess the maternal and neonatal outcomes after expectant management of pre-viable preterm premature rupture of membranes (PPROM). Data Sources:We searched PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Scopus, and Web of Science databases for publications from 2008 to 2018 and ClinicalTrials.gov. Methods of Study Selection:All studies that reported pregnancy outcomes of pre-viable PPROM were included. Excluded were the review articles, case reports, and studies that exclusively included patients with a particular characteristic (oligohydramnios/prolonged latency), those evaluating the effect of a specific intervention, or the ones providing aggregate data from which information for patients with PPROM <24 weeks could not be delineated.Tabulation, Integration, and Results: Eighteen studies were reviewed that examined the outcomes of 1,372 pre-viable PPROM women following expectant management. Data was extracted in the form of predesigned tables. We used Microsoft Excel to integrate the results of included studies. The overall neonatal survival to discharge was 41.5%. Of these, 48.8% neonates survived without a major morbidity. Respiratory morbidity was the most common morbidity among surviving neonates: 49.5% neonates suffered from respiratory distress syndrome, 30% from bronchopulmonary dysplasia, and 10.7% from pulmonary hypoplasia. Chorioamnionitis was the most frequently observed maternal morbidity, complicating 49.3% pre-viable PPROM. The predictors for favorable outcomes included a later gestational age at PPROM and delivery, absence of oligohydramnios, and iatrogenic PPROM. Of note, 21.6% of pre-viable PPROM women opted for the termination of pregnancy. Conclusion:The neonatal survival rate of pre-viable PPROM after expectant management is 4 of 10 affected neonates, and nearly half of them survive without any major morbidity. Maternal morbidity remains substantial, however, serious maternal complications are rare.

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Section: Resultsmentioning

confidence: 99%

Section: Neonatal Survival To Dischargementioning

confidence: 99%

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Perinatal Outcomes of Pre-viable Preterm Premature Rupture of Membranes

Mukhtar¹

2018

J Gyn Obs Bul

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“…Two recently published observational studies have focused on the outcome of very preterm respectively of very low birth weight infants after preterm premature rupture of fetal membranes (PPROM). One single center study from the Netherlands enrolling 160 women with PPROM before 24 weeks gestational age, who admitted to the Rotterdam Medical Center between 2002 and 2011, were analyzed [14]. In parallel, there was a publication from the German Neonatal Network (GNN) enrolling about 6,000 very low birth weight infants, whose data were analyzed under the aspect of PPROM as a potential risk factor for adverse neonatal outcomes [5].…”

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confidence: 99%

Preterm Premature Rupture of Membranes: A Constant Challenge in Perinatal Medicine?

Gortner¹

2016

Klin Padiatr

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Two recently published observational studies have focused on the outcome of very preterm respectively of very low birth weight infants after preterm premature rupture of fetal membranes (PPROM). One single center study from the Netherlands enrolling 160 women with PPROM before 24 weeks gestational age, who admitted to the Rotterdam Medical Center between 2002 and 2011, were analyzed 14. In parallel, there was a publication from the German Neonatal Network (GNN) enrolling about 6,000 very low birth weight infants, whose data were analyzed under the aspect of PPROM as a potential risk factor for adverse neonatal outcomes 5.

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“…One single center study from the Netherlands enrolling 160 women with PPROM before 24 weeks gestational age, who admitted to the Rotterdam Medical Center between 2002 and 2011, were analyzed [14]. In parallel, there was a publication from the German Neonatal Network (GNN) enrolling about 6,000 very low birth weight infants, whose data were analyzed under the aspect of PPROM as a potential risk factor for adverse neonatal outcomes [5].…”

mentioning

confidence: 99%

Untitled

2016

Klin Padiatr

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Maternal and Neonatal Outcomes of Preterm Premature Rupture of Membranes before Viability

Abstract: This large single center study can provide good foundation for counseling parents on previable PPROM, especially the prognosis of PPROM<20 weeks of pregnancy is of additional value.

Cited by 21 publications

References 28 publications

Perinatal Outcomes of Pre-viable Preterm Premature Rupture of Membranes

Perinatal Outcomes of Pre-viable Preterm Premature Rupture of Membranes

Preterm Premature Rupture of Membranes: A Constant Challenge in Perinatal Medicine?

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