Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group

Abstract

Introduction Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the association between parental occupational exposures and hepatoblastoma. Methods In our case-control study, we identified cases (n=383) from the Children’s Oncology Group and controls from birth certificates (n=387), which were frequency matched to cases on year and region of birth, sex, and birth weight. Occupational exposure in the year prior to and during the index pregnancy was collected through maternal interview and analyzed using unconditional logistic regression. Results The odds of both paternal and maternal “Likely” exposure to paints was elevated among cases compared to controls (Paternal Odds Ratio [OR]: 1.71, 95% Confidence Interval [CI]: 1.04, 2.81; Maternal OR: 3.29, 95% CI: 0.32, 33.78) after adjustment for matching factors and the confounding factors of maternal race (maternal only) and household income. In addition, paternal exposure to other chemicals was also elevated when adjusting for matching factors only (OR: 1.53, 95% CI: 1.02, 2.30). Discussion The results of our study provide further evidence of an association between parental occupation and hepatoblastoma. These results warrant further investigation of the etiologically relevant timing of occupational exposure to fumes and chemicals related to hepatoblastoma.

Clinical features and a prognostic nomogram based on the SEER database for hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma among children and adolescents

“…The social factor (race) is an independent prognostic factor for HB. Similar findings were also noted in a previous study conducted in the USA ( 11 ). Black patients tend to have poor outcomes.…”

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

“…This phenomenon is partly due to increased prematurity Ivyspring International Publisher and very low birth weight [4,5]. The development of hepatoblastoma is also associated with some environmental factors, such as parental exposure to tobacco, metal and petroleum products [6][7][8][9]. Moreover, it is strongly associated with familial adenomatous polyposis [10], Beckwith-Wiedemann syndrome [11], and Glycogen storage disease [12], indicating some genetic underpinnings.…”

The Genetic Changes of Hepatoblastoma

“…Janitz et al. had confirmed that maternal and paternal occupational exposures to paints were etiologically relevant to hepatoblastoma ( 44 ). Other studies indicated that parental occupational exposures to wood dust, metal fumes, and petroleum products also could be the risk factors ( 45 , 46 ).…”