Maternal and perinatal outcomes and pharmacological management of Covid-19 infection in pregnancy: a systematic review protocol

Abstract

Background: Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general population; however, there is scarcity of information related to pharmacological management and maternal and perinatal outcomes during the pandemic. Altered physiological, anatomical, and immunological response during pregnancy makes it more susceptible to infections. Furthermore, during pregnancy, a woman undergoes multiple interactions with the health care system that increases her chance of getting infected; therefore, managing pregnant population presents a unique challenge. Research questions: This systematic review seeks to answer the following questions in relation to COVID-19: What are the different clinical characteristics presented in maternal and perinatal population? What are the different maternal and perinatal outcome measures reported? What are the distinct therapeutic interventions reported to treat COVID-19? Is it safe to use "medications" used in the treatment of COVID-19 during antenatal, perinatal, postnatal, and breastfeeding?

COVID-19 Preventive Measure Practices and Knowledge of Pregnant Women in Guraghe Zone Hospitals

“…2 ,– 18–21 Although pregnant women do not seem to have an increased susceptibility to COVID−19 or more severe complications than non-pregnant adults, the available studies suggest that they may have the risk of adverse pregnancy outcomes. 22 , 23 …”

“…2,-18-21 Although pregnant women do not seem to have an increased susceptibility to COVID−19 or more severe complications than non-pregnant adults, the available studies suggest that they may have the risk of adverse pregnancy outcomes. 22,23 A study conducted in New York City shows more than one in eight asymptomatic patients who were admitted to the labor and delivery unit were positive for SARS-CoV-2. 1 A case study conducted in the USA reports a high-risk pregnant woman who developed respiratory failure associated with COVID-19, possible vertical transmission of COVID-19 infection in this case.…”

Pregnant and Newborn Health in COVID-19 Pandemic: Knowledge level, Attitude and Perspective of Obstetricians & Gynecologists and Pediatricians in Turkey (A Survey-based Study)

“…The coronavirus is transmitted to humans through droplets or contact of contaminated surfaces with mucous membranes [5]. Clinical findings of the disease are fever, cough, myalgia, headache, diarrhea, neurological findings in some cases, rash, and thrombosis [14][15][16][17]. In general, the disease has a mild course, with 14% of patients requiring hospitalization and oxygen support, and 5% intensive care and mortality is 2% [4,14].…”

Global contributions of pharmacists during the COVID‐19 pandemic

“…One live event was with OSUWMC pharmacists who shared their experience with critically ill COVID‐19 patients. Pharmacists across the corporation are involved in published and ongoing COVID‐19 investigational and clinical outcomes' research projects 26,27 …”