Maternal and perinatal outcomes in the COVID-19 Omicron wave in comparison with the Delta wave: a multicenter observational study

Jarraya, A.; Kammoun, M.; Bouhamed, O.; Ellouze, Y.; Doukali, O.; Kolsi, K.

doi:10.36129/jog.2022.74

Cited by 5 publications

(12 citation statements)

References 29 publications

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“…Even if several previous studies estimate that the Omicron variant gives less severe forms [3,4,5] and announces the end of the pandemic [11,12,13], our study showed that COVID-19 persists and the risk of severe and complicated forms caused by this variant should never be underestimated [14], especially during pregnancy [15,16,17]. This study also showed the efficiency of the RNA vaccine against the Omicron variant.…”

Section: Discussioncontrasting

confidence: 42%

“…During pregnancy, the severity of COVID-19 was reduced during the Omicron wave in comparison with the Delta wave with lower rates of pneumonia requiring oxygen support [3]. In our population, maternal mortality among non-vaccinated pregnant women requiring hospital admission was reduced from 14.2% during the delta wave to 2.2%during the Omicron wave [3]. It has been reported that during pregnancy, vaccination improves maternal and perinatal outcomes by reducing the severity of COVID-19 [7].…”

Section: Introductionmentioning

confidence: 52%

“…The Omicron variant (B.1.1.529), becoming the dominant SARS-CoV-2 virus circulating in the world, appears to cause less severe acute illness than previous variants [4,5], at least in vaccinated people [6]. During pregnancy, the severity of COVID-19 was reduced during the Omicron wave in comparison with the Delta wave with lower rates of pneumonia requiring oxygen support [3]. In our population, maternal mortality among non-vaccinated pregnant women requiring hospital admission was reduced from 14.2% during the delta wave to 2.2%during the Omicron wave [3].…”

Section: Introductionmentioning

confidence: 98%

“…Furthermore, since its emergence, SARS-CoV2 hasn't stopped mutating [2]. Several variants appeared and caused different epidemiologic waves [3]. The Omicron variant (B.1.1.529), becoming the dominant SARS-CoV-2 virus circulating in the world, appears to cause less severe acute illness than previous variants [4,5], at least in vaccinated people [6].…”

Section: Introductionmentioning

confidence: 99%

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Does COVID-19 vaccination still have a role in maternal and perinatal outcomes during the Omicron era? A multicentre observational study

Jarraya¹,

Kammoun²,

Kanoun³

et al. 2022

It Journ Gyn Obs

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Objective. COVID-19 vaccination has a reduced efficiency against the Omicron variant. The aim of this study was to assess the clinical impact of COVID-19 vaccination on maternal and perinatal outcomes during the Omicron wave. Materials and Methods.This was an observational multicenter study, pregnant women who gave birth while infected by SARS CoV2 during the Omicron waves were included.Patients with incomplete vaccination and recurrent infections were excluded. Patients were divided into 2 groups: the Vaccinated Group included pregnant women with completed vaccination (≥ 3 doses of mRNA vaccine or 2 doses ≤ 6 months); the Non-vaccinated Group included pregnant women who had no COVID-19vaccination. Data about obstetrical and fetal outcomes in both groups were compared.Results. In total, 59 vaccinated and 49 unvaccinated patients were included. The incidence of patients requiring oxygen support was reduced from 36.7% to 1.7% with p < 0.001. The mode of delivery was comparable in both groups. The need for referral to an intensive care unit was reduced from 22.4% to 1.7% with p ≤ 0.001. The length of hospitalization was reduced from 6.8 ± 5 to 2.8 ± 2 days, with p ≤ 0.001. The prematurity rate was comparable in both groups, but the need for neonatal intensive care admission was reduced from 22.4% to 4.1% with p = 0.019. Conclusions.The COVID-19 vaccination seems to be efficient during the Omicron waves. Obstetrical and neonatal outcomes were improved with complete vaccination. Pregnant women should be advised to have a complete vaccination status.

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Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Does COVID-19 vaccination still have a role in maternal and perinatal outcomes during the Omicron era? A multicentre observational study

Jarraya¹,

Kammoun²,

Kanoun³

et al. 2022

It Journ Gyn Obs

View full text Add to dashboard Cite

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“…Since the emergence of the SARS COV2 virus in 2019 in China, many variants have been seen [1]. This may explain why COVID-19 appears with a large spectrum of clinical presentations and a nonnegligible occurrence of life-threatening and fatal complications, particularly with the Delta variant, which seems to be the most harmful [2]. COVID-19 generally manifests with fever, cough or gastro-intestinal troubles, but sometimes it can lead to severe outcomes with pneumonia or ARDS (acute respiratory distress syndrome), renal failure, thrombo-embolic events and multiple organ dysfunctions, mostly in patients with comorbidities or with immunodeficiency disorders [3].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study

Kammoun¹,

Jarraya²,

Mejdoub³

2022

J Inter Med Res & Rep

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Introduction: Pregnant women are vulnerable to SARS-CoV2 infection, particularly with the Delta variant. The aim of our study is to describe the COVID-19 syndrome among non-vaccinated pregnant women during the delta wave and to investigate risk factors for severe forms. Methods: In this study, we included all non-vaccinated pregnant women who tested positive for COVID-19 and who required hospital admission at any stage of gestation during the Delta wave in the maternity of Sfax, Tunisia. Patients were divided into 2 groups according to the mode of delivery in case of completed pregnancies and according to the severity of the disease. Severe COVID-19 is considered when the pregnant woman requires advanced oxygen support or intensive care unit referral. We performed univariate and multivariate logistic regression models to investigate the predictors of severe maternal outcomes among infected pregnant women. The significance level was set top ≤ 0.05. Results: one hundred patients were included. Severe adverse outcomes were observed in 23 patients (group1). The mortality rate during the Delta wave was 6%. The mode of delivery had not influenced the maternal and perinatal outcomes. Age >35 years old [OR 3.16, 95% CI 1.13- 8.84], BMI>30 kg/m2 [OR 2.63, 95% CI 1.0 -6.95], preeclampsia [OR 4.0, CI 95% 1.04- 15.32], dyspnea [OR 7.55, 95% CI 2.62- 21.7], cytolysis [ OR 4.6, 95% CI 1.48- 14.2], and lung injury in CT Scan > 50% [OR9.6, 95%CI 1.48-62.1] were significantly associated with an increased risk of severe maternal outcomes. Conclusions: During the delta wave in Tunisia, non-vaccinated pregnant women seem to be at higher risk of severe maternal outcomes and maternal deaths. The main risk factors for severe outcomes were age 35, obesity, preeclampsia, cytolysis, and severe lung damage in the CT scan.

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COVID‐19 Omicron variant infection has minimal impact on maternal and neonatal outcomes: A cross‐sectional cohort study

Ying,

Mengmeng,

Lan

et al. 2023

Nursing Open

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AimTo explore the impact of the Omicron variant on maternal and neonatal outcomes.DesignCross‐sectional cohort study of women giving live birth in a single hospital in Shanghai in December 2022.MethodsDemographic characteristics, maternal and neonatal outcomes and laboratory testing results were retrieved from medical records. Propensity score matching was used to match COVID‐19‐positive and ‐negative women. Differential analysis was used to assess associations between COVID‐19 and in‐hospital maternal and neonatal outcomes.ResultsA total of 1508 women were included, comprising 729 natural births, 741 caesarean sections and 38 forceps deliveries. After 1:1 matching, 310 clients were included for analysis with each 155 in COVID‐19‐positive and ‐negative groups. Higher maternal fever was found in all modes of delivery, and higher preterm birth and lower pH value of blood gas of the umbilical artery in the vaginal delivery subgroup (p < 0.05). Other maternal and neonatal outcomes showed no significant difference between COVID‐19‐positive and ‐negative clients.

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Maternal and perinatal outcomes in the COVID-19 Omicron wave in comparison with the Delta wave: a multicenter observational study

Cited by 5 publications

References 29 publications

Does COVID-19 vaccination still have a role in maternal and perinatal outcomes during the Omicron era? A multicentre observational study

Does COVID-19 vaccination still have a role in maternal and perinatal outcomes during the Omicron era? A multicentre observational study

COVID-19 Severity Among Non-Vaccinated Pregnant Women During the Delta Wave in Tunisia: A Retrospective Monocentric Study

COVID‐19 Omicron variant infection has minimal impact on maternal and neonatal outcomes: A cross‐sectional cohort study

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