Maternal Anemia and Vitamin D deficiency: associations with neonatal hemoglobin levels and the vitamin D status

Park, Sook-Hyun

doi:10.14734/pn.2017.28.1.4

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Furthermore, an interesting extension of the models would be to increase the time intervals for which the models are valid and to incorporate also birth weight, while subcategorizing to a small appropriate size for gestational age (including all low birth weight infants), which is also a factor determining cHb values in neonates [18,25]. Also distinguishing between fetal and adult hemoglobin as well as the measurement of immature platelet fraction parameters would be helpful to better model the postnatal hematological changes.…”

Section: Discussion Conclusion and Outlookmentioning

confidence: 99%

Reference Ranges for Hemoglobin and Hematocrit Levels in Neonates as a Function of Gestational Age (22–42 Weeks) and Postnatal Age (0–29 Days): Mathematical Modeling

et al. 2019

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Hematological values of neonates need to be interpreted taking into account the fact that the reference ranges depend on the age of the neonate. We aimed to derive two general mathematical models for reference ranges for hemoglobin concentration (cHb) and hematocrit (Hct) levels in neonates as a function of gestational age (GA) and postnatal age (PNA), since it is known that GA and PNA are independent factors determining cHb and Hct. For this purpose, cHb and Hct values from the data set of Henry and Christensen (2015, Clin. Perinatol., 42, 483–497) from about 100,000 neonates (GA: 22–42 weeks, PNA: 0–28 days) were used and general models with two quadratic functions were derived. To the best of our knowledge, the models we have developed are the first published ones to provide reference ranges for cHb and Hct for neonates incorporating the parallel dependence on GA and PNA.

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Section: Discussion Conclusion and Outlookmentioning

confidence: 99%

Reference Ranges for Hemoglobin and Hematocrit Levels in Neonates as a Function of Gestational Age (22–42 Weeks) and Postnatal Age (0–29 Days): Mathematical Modeling

et al. 2019

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Vitamin D deficiency and anemia in pregnant women: a systematic review and meta-analysis

et al. 2021

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Context Epidemiological studies suggest an association between vitamin D deficiency and anemia. Evidence of this relationship in pregnant women, however, is scarce. Objective The aim of this systematic review was to investigate the association between vitamin D deficiency and gestational anemia through observational studies. Data Sources The PubMed, Scopus, Web of Science, ScienceDirect, Embase, and Virtual Health Library databases were searched from inception to April 2021. Study Selection Original articles reporting observational studies that investigated the association between vitamin D deficiency and gestational anemia were included. Articles that did not have an abstract, as well as reviews articles, experimental studies, and editorials, were excluded. Two reviewers independently performed study selection, data extraction, and assessment of study quality. Disagreements between the reviewers were resolved by a third reviewer. Data Extraction Study quality was assessed by 2 scales. Data were extracted from eligible studies and arranged in a 2 × 2 table. Odds ratios with 95% confidence intervals for the risk of the outcome were estimated using a fixed-effect model. Results In total, 985 studies were retrieved, of which 17 were included in the systematic review: 11 cohort studies, 3 case-control studies, and 3 cross-sectional studies. For the meta-analysis, 8 studies with a total of 6530 women were included. There was a 61% increase in the odds of anemia in pregnant women with vitamin D deficiency (OR = 1.61; 95%CI, 1.41–1.83; I2 = 48%). Conclusions Vitamin D deficiency may be a risk factor for anemia in pregnant women. Systematic Review Registration PROSPERO registration no. CRD42020182697.

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Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

Rostami

Moghaddam-Banaem

Ghasemi

et al. 2020

Koomesh

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Introduction:There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pregnant women with vitamin D deficiency.Materials and Methods: The present study was performed in October 2019 from a secondary and nonpredetermined analysis of the effect of vitamin D supplementation and comparison of serum vitamin D levels on blood parameters from a randomized controlled clinical trial. 215 pregnant mothers with vitamin D deficiency were entered in the study and were divided into two treatment groups of 50,000 units and 1000 units.Results: Mean serum levels of Hematocrit, Platelets, and Ferritin after treatment in the treatment groups with 50000 and 1000 unites were 38.6± 3.03 vs 36.05± 2.8 (P<0.38), 243083 ± 55302 vs 215942 ± 45513 (P<0.29) and 42.3± 33.5 vs 28.8± 21.7 (P<0.04), respectively. The mean Hemoglobin level in the treatment groups with 50,000 and 1000 units were 12.08± 1.17 vs. 12.3± 2.5 (P<0.84), respectively. In both groups, there was a significant relationship between serum vitamin D level, Hemoglobin and Hematocrit levels before treatment. (Respectively P<0.02, P<0.02 and P<0.05). The serum Ferritin level was significantly higher with serum vitamin D after treatment (P<0.04). Conclusion:This study showed that the results of two therapeutic groups in pregnant women with vitamin D deficiency, especially a dose of 50,000 units of vitamin D, compared to the first trimester of pregnancy, had different effects on the hematologic indices.

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Maternal Anemia and Vitamin D deficiency: associations with neonatal hemoglobin levels and the vitamin D status

Cited by 3 publications

References 25 publications

Reference Ranges for Hemoglobin and Hematocrit Levels in Neonates as a Function of Gestational Age (22–42 Weeks) and Postnatal Age (0–29 Days): Mathematical Modeling

Reference Ranges for Hemoglobin and Hematocrit Levels in Neonates as a Function of Gestational Age (22–42 Weeks) and Postnatal Age (0–29 Days): Mathematical Modeling

Vitamin D deficiency and anemia in pregnant women: a systematic review and meta-analysis

Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

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