Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring

Harju, Maijakaisa; Pekkanen, Juha; Heinonen, Seppo; Keski‐Nisula, Leea

doi:10.1111/jog.13569

Cited by 8 publications

(2 citation statements)

References 43 publications

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“…Reductions in iron concentrations during pregnancy are also linked to high rates of foetal growth restriction, as well as disturbances to blood pressure, iron storage (liver iron content) and haematocrit concentrations in offspring . Iron deficiency has even been linked to offspring conditions including asthma, schizophrenia spectrum disorders, kidney dysfunction and an altered metabolic profile . In contrast, iron supplementation has been shown to increase maternal risk of developing GDM, possibly through oxidative stress mechanisms .…”

Section: Long Term Effects Of Micronutrient Deficiencies On Offspringmentioning

confidence: 99%

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

Hofstee

McKeating

Perkins

et al. 2018

Clin Exp Pharma Physio

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Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation. In contrast, animal studies have demonstrated how diets high or low in specific micronutrients influence offspring physiology. Many of these studies highlight the importance of the placenta in determining disease risk. This review will explore the effects of individual vitamins, minerals and trace elements on offspring disease outcomes and discuss several key placental adaptations that are affected by multiple micronutrients. These placental adaptations include micronutrient induced dysregulation of oxidative stress, altered methyl donor availability and its impact on epigenetic mechanisms as well as endocrine dysfunction. Critical gaps in our current knowledge and the relative importance of different micronutrients at different gestational ages will also be highlighted. Finally, this review will discuss the need for further studies to characterise the micronutrient status of Australian women of reproductive age and correlate micronutrient status to placental adaptations, pregnancy complications and offspring disease.

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Section: Long Term Effects Of Micronutrient Deficiencies On Offspringmentioning

confidence: 99%

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

Hofstee

McKeating

Perkins

et al. 2018

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…Hung et al [37] studied the effect of respiratory failure (RF) on pregnancy. The authors determined that the most common obstetric cause of acute respiratory failure is hemorrhage and hypertensive disorders.…”

Section: Introductionmentioning

confidence: 99%

MODERN VIEW ON CHRONIC RESPIRATORY DISEASES IN PREGNANT (review)

Лазуренко

Bilyi

Лященко

et al. 2022

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Disorders in the fetoplacental complex of pregnant women with chronic respiratory diseases (CRD) is one of the actual problems of modern obstetrics in medical, economic and social aspects. Respiratory diseases in the context of disorders of the fetoplacental complex (FPC) may be a comorbid process, a background to the pathology of pregnancy, or a premorbid condition that contributes to the development of placental dysfunction (PD) or even initiates it; morphophysiological changes characteristic of pregnancy also affect the state of the respiratory system, moderating the course of bronchoobstructive pathology. The presence of respiratory diseases in women, the impact of its treatment and features of the course and medical support of pregnancy in these conditions affect the condition of both the woman and the fetus, and in the future - the physical and neuropsychological development of the child.

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Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

Wang,

James,

Donovan

et al. 2024

Comprehensive Physiology

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From the results of well‐performed population health studies, we now have excellent data demonstrating that deficits in adult lung function may be present early in life, possibly as a result of developmental disorders, incurring a lifelong risk of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease. Suboptimal fetal development results in intrauterine growth restriction and low birth weight at term (an outcome distinct from preterm complications), which are associated with subsequent obstructive disease. Numerous prenatal exposures and disorders compromise fetal development and these are summarized herein. Various physiological, structural, and mechanical abnormalities may result from prenatal disruption, including changes to airway smooth muscle structure–function, goblet cell biology, airway stiffness, geometry of the bronchial tree, lung parenchymal structure and mechanics, respiratory skeletal muscle contraction, and pulmonary inflammation. The literature therefore supports the need for early life intervention to prevent or correct growth defects, which may include simple nutritional or antioxidant therapy. © 2024 American Physiological Society. Compr Physiol 14:5729‐5762, 2024.

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Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring

Cited by 8 publications

References 43 publications

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

MODERN VIEW ON CHRONIC RESPIRATORY DISEASES IN PREGNANT (review)

Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

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