Maternal Antiretroviral Treatment for HIV Infection and Risk of Small for Gestational Age Birth: A Systematic Review and Meta-Analysis of Protease Inhibitor-Based Treatment and Timing of Treatment

Is there a link between antiretroviral therapy and hypertensive disorders of pregnancy?

“…Thus, if ART causes placental dysfunction, one would expect an impact on fetal growth which is far from established. In a recent meta-analysis [12], PI-based ART was associated with a possible slightly increased risk of SGA compared with non-PI-based ART. Another recent meta-analysis found no significant association between prenatal exposure to PIs compared to non-nucleoside reverse transcriptase inhibitors (NNRTIs) for SGA but an increased risk of very SGA [13].…”