Maternal benzo[a]pyrene exposure is correlated with the meiotic arrest and quality deterioration of offspring oocytes in mice

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

“…In vitro experiments further confirmed that culture medium supplemented with BaP causes porcine oocyte meiotic arrest (Miao et al, 2018). Unexpectedly, we observed that female mouse exposure to BaP even led to a reduction in oocyte meiotic maturation and early embryonic development in the resulting offspring (Sui et al, 2020). Although BaP is a toxicant to oocytes, certain chemicals, such as melatonin and ginsenoside compound K, might prevent oocytes from BaP exposure-mediated defects (Miao et al, 2018;Luo et al, 2020).…”

The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function

“…2 ). Animal models and in vitro work has shown that exposure to PACs like BaP, DMBA and 3MC target different stages of folliculogenesis and deplete ovarian germ cells ( Lim et al, 2016 , Luderer et al, 2019 ); exhaust primordial follicles via atresia or accelerated primordial follicle recruitment ( Borman et al, 2000 , Jurisicova et al, 2007 , Matikainen et al, 2001 , Mattison, 1980 , Mattison and Thorgeirsson, 1979 , Pru et al, 2009 , Rhon-Calderón et al, 2018 , Sobinoff et al, 2011 ); inhibit pre-antral and antral follicle growth ( Einaudi et al, 2014 ); cause DNA damage and form DNA-adducts ( Igawa et al, 2009 , Lim et al, 2013 , Yao et al, 2017 ); induce oxidative stress and ROS production ( An et al, 2011 , Siddique et al, 2014 , Tsai-Turton et al, 2007 , Zhang et al, 2018 ); and impede oocyte maturation ( Sui et al, 2020 ). Additionally, evidence has shown that PACs disrupt ovarian steroidogenesis via altered enzymatic expression and activity leading to altered levels in secreted estradiol, androgen and progesterone ( Archibong et al, 2012 , Dewailly et al, 2016 , Liu et al, 2020 , Neal et al, 2007 , Xu et al, 2010 ).…”

“…For example, in 5- to 6-week old mice, exposure to BaP, 3MC and DMBA (80 mg/kg) resulted in increased pyknosis and cytolysis of the oocytes in primordial follicles ( Mattison, 1980 ). BaP exposure has also been shown to impair meiotic progression in both porcine ( Miao et al, 2018 ) and murine ( Sui et al, 2020 , Sobinoff et al, 2012b ; Zhang et al, 2018 ) oocytes, compromising oocyte maturation and quality through altered spindle assembly, chromosomal alignment, cytoskeleton structures and mitochondrial integrity. In fact, exposure to BaP can cause mitochondrial dysfunction and induce oxidative stress, leading to increased levels of reactive oxygen species (ROS), lipid peroxidation and apoptosis Lim et al, 2015b , Sobinoff et al, 2012b Zhang et al, 2018 ).…”

“…In fact, exposure to BaP can cause mitochondrial dysfunction and induce oxidative stress, leading to increased levels of reactive oxygen species (ROS), lipid peroxidation and apoptosis Lim et al, 2015b , Sobinoff et al, 2012b Zhang et al, 2018 ). Similarly, maternal BaP exposure can also significantly alter meiotic progression, cause mitochondrial dysfunction, and induce early apoptosis in offspring, thus compromising oocyte quality and developmental competence ( Sui et al, 2020 ). Together, these effects of BaP may decrease fertilization potential and significantly reduce litter sizes of exposed females ( Zhang et al, 2018 ).…”

Effects of Crude Oil contaminated Water on the reproductive system of Female Wistar Rats

“…Exposure to benzopyrene (BaP), a PAH found in crude oil caused degenerative changes in the ovaries of mice and the changes include pyknosis and cytolysis of the oocytes in (Mattison et al 1980). BaP exposure has also been shown to impair meiotic progression in both porcine (Miao et al, 2018) and murine oocytes, compromising oocyte maturation and quality through altered spindle assembly, chromosomal alignment, cytoskeleton structures and mitochondrial integrity (Sui et al, 2020;Sobinoff et al, 2012;Zhang et al, 2018). Heavy metals present may also have contributed to these findings.…”