Maternal blood biomarkers and adverse pregnancy outcomes: a systematic review and meta-analysis

Gomes, James; Au, Felicia; Basak, Ajoy; Cakmak, Sabit; Vincent, Renaud; Kumarathasan, Premkumari

doi:10.1080/10408444.2019.1629873

Cited by 35 publications

(29 citation statements)

References 80 publications

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“…In a systematic review, similar results were found in populations in the United States, Iran, and Denmark [31]. Specifically, our study found that elevated CRP and C3 levels in early pregnancy increased the risk of PTB, while ferritin and C4 levels were not associated with PTB throughout pregnancy.…”

Section: Discussionsupporting

confidence: 87%

Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women

Huang

Tian

Liu

et al. 2020

BMC Pregnancy Childbirth

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Background: Currently, there are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). The results, however, are inconsistent. Therefore, the aim of this study was to estimate the relationship between maternal serum inflammatory indicators and PTB in a nested case-control (NCC)study. Methods: A NCC study was conducted by Guangxi Birth Cohort Study which enrolled a total of 6203 pregnant women between 5 0/7 and 34 6/7 weeks of gestational age (wGA) from six cities in China between 2015 and 2016. There were 206women who delivered preterm (< 37 0/7 wGA), and 412 women who delivered term birth, those women were matched by maternal age, birth place, gender of infants, and wGA at blood collection. The inflammatory indicators were quantified by immunoturbidimetric methods. Results: Highest quartile concentrations of all inflammatory indicators were determined versus median. After adjusting for maternal age, high levels of CRP (CRP > 16.60 mg/L) are related to the risk of PTB (OR = 2.16, 95% CI: 1.02-4.56, p = 0.044) in the first trimester. The association of C3 was extremely related to those who delivered PTB (OR = 2.53, 95% CI: 1.14-5.64, p = 0.023) in the first trimester. Moreover, no significant associations were found in C4 (p = 0.079) and ferritin (p = 0.067) between PTB. Conclusions: Elevated concentrations of CRP and C3 in the first trimester were associated with increased risk of PTB. Inflammatory indicators may act a pivotal part in early diagnosis and prognosis of PTB.

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Section: Discussionsupporting

confidence: 87%

Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women

Huang

Tian

Liu

et al. 2020

BMC Pregnancy Childbirth

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“…It is increasingly clear that maternal inflammatory responses have a strong association with poor pregnancy outcomes. Although pro-inflammatory cytokines are the most broadly understood for their significant effects on birth outcomes, the nuanced relationship with anti-inflammatory cytokines provides a mechanism as biomarkers for preterm birth and other complications [27]. Given the associations between pregnancy-specific anxiety and poor birth outcomes, it is critical to assess the longitudinal changes in these markers both independently and in relation to psychosocial measures of anxiety as well as association with interventions focused on maternal anxiety and depression.…”

Section: Discussionmentioning

confidence: 99%

Associations between Physiological Biomarkers and Psychosocial Measures of Pregnancy-Specific Anxiety and Depression with Support Intervention

Weis

Yuan

Walker

et al. 2021

IJERPH

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Stress and anxiety significantly impact the hypothalamic–pituitary axis, and in pregnancy, the subsequent maternal–fetal response can lead to poor outcomes. The objective of this study was to assess the association between psychosocial measures of pregnancy-specific anxiety and physiologic inflammatory responses. Specifically, to determine the effectiveness of the Mentors Offering Maternal Support (M-O-M-STM) program to reduce psychosocial anxiety and associated inflammatory response. In conjunction with measures of pregnancy-specific anxiety and depression, serum biomarkers (IL-2, IL-6, IL-10, IL1-B, TNF-α, CRH, CRP, and cortisol) were analyzed for each trimester throughout pregnancy. Results demonstrated that women receiving the M-O-M-STM intervention had longitudinally sustained lower TNF-α/IL-10 ratios than the control group, and it was significantly associated with psychosocial measures of anxiety, specifically for fears of labor and spouse/partner relationships. Additionally, the anxiety of spouse/partner relationships was significantly associated with IL-6/IL-10 ratios. The findings highlight the important counter-regulatory relationship between anti- and pro-inflammatory cytokines and provide insight into the distinct physiologic responses to pregnancy-specific anxiety with early prenatal intervention.

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“…Hair proteins observed in individual mothers and children contained 2,269 unique 'proteoforms' or protein isoforms; 1,438 proteins were commonly observed in mothers, 1,368 proteins were commonly observed in children, whereas 1,288 hair proteins showed individual variability among mothers and children. Higher spectral counts (p=0.0004) and higher numbers of proteins (p=0.001) were observed in mothers compared to children (Fig.1), perhaps reflecting a wider array of biological functions in adult females related to reproduction (24)(25)(26), aging (27,28), or disease states (29). These age differences are explored further in subsequent analyses.…”

Section: Features Of Hair Proteinsmentioning

confidence: 95%

Proteins observed in scalp hair from preschool children

Singhal

et al. 2021

Preprint

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Early childhood experiences have long-lasting effects on subsequent mental and physical health, education, and employment. Measurement of these effects relies on insensitive behavioral signs, subjective assessments by adult observers, neuroimaging and neurophysiological studies, or remote epidemiologic outcomes. Despite intensive search, no biomarkers for developmental changes in the brain have been identified. We analyzed scalp hair from healthy children and their mothers using an unbiased proteomics platform to reveal 1368 hair proteins commonly observed in children, 1438 proteins commonly observed in mothers, and 1288 proteins observed sporadically in individual subjects. Mothers showed higher numbers of peptide spectral matches and hair proteins compared to children, with important age-related differences between mothers and children. Age-related differences were also observed in children, with differential protein expression patterns between younger (2 years and below) and older children (3-5 years). Boolean analyses showed greater conservation of hair protein patterns between mothers and their biological children as compared to mothers and unrelated children. The top 5% proteins driving population variability represent biological pathways associated with brain development, immune signaling, and stress response regulation. Non-structural proteins observed in scalp hair may include promising biomarkers to investigate the developmental changes associated with early childhood experiences.One Sentence SummaryThe non-structural proteins observed in scalp hair from preschool children show evidence for heritability, reflect biological functions such as brain development, or immune function and regulation of stress responses, and exhibit age- and sex-related differences across periods of early childhood development.

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Maternal blood biomarkers and adverse pregnancy outcomes: a systematic review and meta-analysis

Cited by 35 publications

References 80 publications

Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women

Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case–control study in Chinese women

Associations between Physiological Biomarkers and Psychosocial Measures of Pregnancy-Specific Anxiety and Depression with Support Intervention

Proteins observed in scalp hair from preschool children

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