Maternal Blood Lead Levels and Pregnancy Outcomes in Lucknow, North India

Awasthi, Sanjay; Awasthi, Rajiv; Srivastava, Rohit

doi:10.1080/00039890009604030

Cited by 5 publications

(9 citation statements)

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“…There are conflicting reports on effects of fetal Pb exposure on birth weight. Increase in birth weight [28,29], no effects [19,30,31] and decrease [3,20,32,33] in birth weight are reported as a result of Pb-exposure. Negligible effects of PbVB on birth weight on applying multiple linear regression, observed during the present study, may be explained as under :…”

Section: Effects Of Lead On Neonatal Birth Weightmentioning

confidence: 94%

An association between maternal lead and cadmium levels and birth weight of the babies in North Indian population

Dwivedi¹,

Jain²,

Jain³

2013

OJOG

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Lead is listed as the 2nd and Cadmium as the 7th hazardous substance by the Agency for Toxic Substances and Disease Registry (ATSDR). Exposure to Lead and Cadmium above the permissible levels among pregnants may cause adverse effects on newborns in the form of Low Birth Weight and Preterm Labor, etc. The objectives of this study were to find out the level of Lead and Cadmium in maternal venous blood and cord blood and to find out the association of the levels of these metals with birth weight of babies. For this, the venous blood and cord blood were collected and quantitative estimation of Lead and Cadmium was carried out by Double Beam Atomic Absorption Spectrophotometer in 1000 women with average Body Mass Index. Results showed higher mean maternal blood Lead level (11.08 μg/dl with range of 2.6 - 21.3) than the normal recommended by Centre of Disease Control and Prevention (10 μg/dl). On the contrary, the mean Cadmium level was 0.095 μg/dl, which was below the normal value as assigned by WHO (0.1 μg/dl). In high Lead exposure group (>10 μg/dl), 43.7% of babies and in high Cadmium exposure group (>0.1 μg/dl), 46.2% of babies were found to have low birth weight. However, this was not statistically significant. Further research in this area in a larger sample size may provide information relevant enough to be transferred to decision makers to implement measures to effectively reduce heavy metals from the environment, thereby protecting future generations from their deleterious effects.

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Section: Effects Of Lead On Neonatal Birth Weightmentioning

confidence: 94%

An association between maternal lead and cadmium levels and birth weight of the babies in North Indian population

Dwivedi¹,

Jain²,

Jain³

2013

OJOG

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“…14,15 High levels of mean maternal BPb level (64.3 µg/dL) has been reported by Ladele et al 16 The level recorded by McMichael et al was 11.2 µg/dL and by Awasthi S et al was 14.34 µg/dL which are much higher than our study. 17,11 The differences in mean BPb between studies can be explained by the variable exposure to various environmental sources in the study population, by the variable mobilisation of lead from bones and differences in laboratory test standards. We reported a significant decrement of 269 gm in mean body weight of babies born to mothers with BPb ≥ 5µg/dL.…”

Section: Discussionmentioning

confidence: 99%

“…10 Whereas Awasthi et al reported direct relation between birth weight and BPb level levels. 11 Factor-Litwak P et al have failed to find an association between the two variables. 12 In view of this, we studied the association between maternal lead exposure and LBW.…”

Section: Introductionmentioning

confidence: 99%

Elevated Maternal Blood Lead Level - A Risk Factor for LBW - An Observational Study

Dhande

Waghmare²,

Badhoniya

et al. 2020

J. Nepal Paedtr. Soc.

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Introduction: Lead exposure is common in women. Lead stored in bones is released during pregnancy and can potentially affect foetal growth. We conducted this study to estimate the effect of maternal blood Lead (BPb) status on Low Birth Weight (LBW) in newborns. Methods: 168 mothers were selected from Special Neonatal Care Unit (SNCU) and Postnatal care (PNC) wards of a tertiary care hospital from Central India and their BPb levels analysed by Graphite Furnace Atomic Absorption Spectrophotometer. Results: 22 (13.10%) mothers having BPb level ≥ 5μg/dL gave 23 births (one twins); of which 65.22% mothers delivered babies with birth weight < 2500gm (LBW) (p = 0.0007). The mean birth weight of newborns of mothers with high BPb levels was significantly lower by 269 gm (p = 0.0265). Mothers with BPb ≥ 5μg/dL delivered 39% premature babies as compared to 10 % mothers with BPb < 5 μg/dL (p < 0.003). Significantly more mothers exposed to kajal, nail polish, lipstick and paints had BPb levels ≥ 5μg/dL. Conclusion: Significant association is detected between maternal BPb and both LBW and prematurity in the given population.

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“…There have been studies about stress and social support, but more work is needed to replicate our findings by directly measuring self-rated health status, its association with birth outcomes and its implications in the reduction of LBW. Various studies from different parts of the world using maternal blood and bone Pb levels and umbilical cord BLL as a marker of prenatal Pb exposure have reported inconsistent results for an association between Pb and LBW (11)(12)(13) . Such inconsistencies in results may be due to different populations with different background risks, different biomarkers used for measuring Pb exposure, or differences in control for important covariates.…”

Section: Discussionmentioning

confidence: 99%

“…LBW infants have an increased risk of mortality during the neonatal period, infancy, childhood and during later during adulthood (2,3) . Previous research has shown that birth weight is influenced by length of gestation, parity, prenatal care, education level of the mother and father, socio-economic status, maternal malnutrition, maternal smoking, environmental tobacco smoke (ETS), short stature of the mother, short birth intervals, maternal and fetal medical problems, as well as certain infections and exposure to environmental agents such as Pb and pesticides (4)(5)(6)(7)(8)(9)(10)(11)(12)(13) . Risk factors for LBW in developing countries are different from those in developed countries.…”

mentioning

confidence: 99%

Determinants of low birth weight in urban Pakistan

Janjua

Delzell

Larson

et al. 2009

Public Health Nutr.

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Objective: To identify determinants of low birth weight (LBW) in Karachi, Pakistan, including environmental exposures and nutritional status of the mother during pregnancy. Design: Cross-sectional study. Participants: Five hundred and forty mother-infant pairs. We interviewed mothers about obstetric history, diet and exposure to Pb. We measured birth weight and blood lead level (BLL). We performed multiple log binomial regression analysis to identify factors related to LBW.

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Maternal Blood Lead Levels and Pregnancy Outcomes in Lucknow, North India

Cited by 5 publications

References 0 publications

An association between maternal lead and cadmium levels and birth weight of the babies in North Indian population

An association between maternal lead and cadmium levels and birth weight of the babies in North Indian population

Elevated Maternal Blood Lead Level - A Risk Factor for LBW - An Observational Study

Determinants of low birth weight in urban Pakistan

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