Maternal Body Mass Index Is a Predictor of Neonatal Hypoglycemia in Gestational Diabetes Mellitus

Abstract

Pregestational BMI should be considered among the predictors of NH in offspring of women with GDM.

Intrapartum glycaemic control and neonatal hypoglycaemia in pregnancies complicated by diabetes: a systematic review

“…This could have contributed to the heterogeneity of study conclusions. There are many other risk factors for neonatal hypoglycaemia, such as small‐for‐gestational‐age or large‐for‐gestational‐age neonates, preterm delivery, maternal BMI and third trimester glycaemic control that have confounded the relationship between maternal and neonatal glucose . None of the six studies that consistently found a relationship between neonatal hypoglycaemia and intrapartum glucose included an analysis that adjusted for potential confounding factors.…”

Betreuung von Neugeborenen diabetischer Mütter. Leitlinie der GNPI, DGPM, DDG, DGHWi, dem DHV, der DGKJ und DGGG. (2k-Level, AWMF-Leitlinien-Register Nr. 024/006, Juli 2017)

“…Im Gegensatz zu anderen Komplikationen einer diabetischen Fetopathie [22] korreliert das Risiko für postnatale Hypoglykämien nicht ohne weiteres mit der mütterlichen Stoffwechsellage gegen Ende der Schwangerschaft. Ein im letzten Trimenon wieder abfallender HbA1c-Wert kann sogar mit einem erhöhten Risiko für eine postnatale Hypoglykämie einhergehen [23]. Dies ist als Folge der wachsenden Insulinsekretionsleistung der fetalen β-Zellen und einer höheren Gesamtmasse insulinsensitiven Gewebes im Feten mit entsprechend höherem materno-fetalen Glukosetransfer zu werten.…”

Does Maternal Body Mass Index Influence Treatment Effect in Women with Mild Gestational Diabetes?

“…6,7 A secondary analysis of the HAPO study as well as other studies have found that neonatal fat mass, fetal hyperinsulinemia, and neonatal hypoglycemia are positively related to maternal size after adjustment for maternal glycemia. 5,[8][9][10] In the original HAPO observational study, LGA birth weight, umbilical cord serum c-peptide, and neonatal fat mass were all increased in a continuous fashion with maternal glucose values. This was true even at maternal glucose levels below thresholds typically used for diagnosis of diabetes during pregnancy.…”