Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats

Dorostghoal, Mehran; Majd, Naeem Erfani; Nooraei, Parvaneh

doi:10.5653/cerm.2012.39.4.144

Cited by 39 publications

(50 citation statements)

References 45 publications

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“…Consistent with previous reports (5,8), we observed significant reductions in both body weight gain and food intake in caffeine-fed immature animals (Fig. 1A, 1C), indicating that reduced body weight gain can be attributed mainly to decreased food intake.…”

Section: Discussionsupporting

confidence: 93%

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

2017

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This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones in young adult rats exposed to caffeine. Exposure to caffeine reduced the size and absolute weight of the testes significantly in immature animals in comparison to control animals, but not in young adult animals exposed to caffeine. In contrast, the adrenal glands were significantly heavier in caffeine-fed young adult rats in comparison to control animals, but not in caffeine-fed immature rats. Our results clearly show that the negative effects of caffeine on the long bones and testes in rats are different according to the age of the rat at the time of exposure, and might therefore be caused by changes to organ sensitivity and metabolic rate at different developmental stages. Although the long bones and testes are more susceptible to caffeine during puberty, caffeine has negative effects on body fat, bone minerals and the adrenal glands when exposure occurs during young adulthood. There is a need, therefore, to educate the public the potential dangers of caffeine consumption during puberty and young adulthood.

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Section: Discussionsupporting

confidence: 93%

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

2017

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“…35,37 Prenatal caffeine exposure has been shown to lower testosterone levels in the male offspring of humans 39 and rats. 7 We found that pubertal caffeine exposure had similar effects on testosterone levels. However, several studies have reported that chronic caffeine consumption increased serum testosterone levels in adult humans 39 and animals.…”

Section: Discussionmentioning

confidence: 56%

“…Caffeine adversely affects endochondral ossification during the course of fetal skeletal growth, and maternal exposure to caffeine causes delayed and abnormal fetal skeletal development. [7][8][9] Although caffeine's detrimental effects on endochondral ossification during the prenatal period have been widely demonstrated, data on its effects on longitudinal bone growth during the pubertal growth spurt are particularly sparse. To the best of our knowledge, there are no interventional studies dedicated to assessing the effects of different doses and exposure durations of caffeine on skeletal development during puberty.…”

Section: Introductionmentioning

confidence: 99%

Peripubertal Caffeine Exposure Impairs Longitudinal Bone Growth in Immature Male Rats in a Dose- and Time-Dependent Manner

Choi

Kim

et al. 2016

Journal of Medicinal Food

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This study investigated the dose- and time-dependent effects of caffeine consumption throughout puberty in peripubertal rats. A total of 85 male SD rats were randomly divided into four groups: control and caffeine-fed groups with 20, 60, or 120 mg/kg/day through oral gavage for 10, 20, 30, or 40 days. Caffeine decreased body weight gain and food consumption in a dose- and time-dependent manner, accompanied by a reduction in muscle and body fat. In addition, it caused a shortening and lightening of leg bones and spinal column. The total height of the growth plate decreased sharply at 40 days in the controls, but not in the caffeine-fed groups, and the height of hypertrophic zone in the caffeine-fed groups was lower than in the control. Caffeine increased the height of the secondary spongiosa, whereas parameters related to bone formation, such as bone area ratio, thickness and number of trabeculae, and bone perimeter, were significantly reduced. Furthermore, serum levels of IGF-1, estradiol, and testosterone were also reduced by the dose of caffeine exposure. Our results demonstrate that caffeine consumption can dose- and time-dependently inhibit longitudinal bone growth in immature male rats, possibly by blocking the physiologic changes in body composition and hormones relevant to bone growth.

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“…The reduction is confirmed by the significant decrease in the sperm count of animals treated with caffeine (Table 3). This reduction in the weight of testes and epididymis might also be due to distortion in spermatogenesis as earlier stated and/or testicular degenerations as a result of the treatment (Wilcox et al, 1988;Dorostghoal et al, 2012).…”

Section: Discussionmentioning

confidence: 97%

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Ekaluo¹,

Uno²,

Ekpo³

et al. 2015

Asian J. of Clinical Nutrition

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The attenuating potential of Trévo Dietary Supplement (TDS), a multi-herbal health drink containing 174 ingredients on caffeine-induced sperm toxicities was studied on albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and TDS orally. The treatment lasted for 65 days. Results indicated statistically significant (p<0.05) decreases in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, TDS effectively attenuated the caffeine induced sperm toxicities in albino rat models in a dose dependent manner.

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Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats

Cited by 39 publications

References 45 publications

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats

Peripubertal Caffeine Exposure Impairs Longitudinal Bone Growth in Immature Male Rats in a Dose- and Time-Dependent Manner

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

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