Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring

Souza, Ana Claudia Mércio Loredo; Souza, Andressa de; Medeiros, Liciane Fernandes; Oliveira, Carla de; Scarabelot, Vanessa Leal; Silva, Rosane Souza da; Bogo, Maurı́cio Reis; Capiotti, Katiúcia Marques; Kist, Luiza Wilges; Bonan, Carla Denise; Caumo, Wolnei; Torres, Iraci Lucena da Silva

doi:10.1016/j.brainres.2014.10.039

Cited by 30 publications

(15 citation statements)

References 78 publications

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“…These findings are in accordance with a study [29], which reported the beneficial effects and the positive roles of GTE on the autonomic nervous system based on its ability to penetrate the blood brain barrier and affect brain maturation and development [30]. On the other hand, it has also been shown that maternal caffeine intake, which is one of the components of GT, alters neuromotor development through interfering with cholinergic neurotransmission during brain development [31]. …”

Section: Discussionsupporting

confidence: 91%

Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development

et al. 2017

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BackgroundGreen tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20 or 50 g/L, beginning the day of conception until the third week after delivery, postnatal day 22 (PD 22). Mice pups were subjected to behavioral testing to assess sensory motor reflexes, locomotion, anxiety, and learning on various postnatal days.ResultsPerinatal exposure to GTE resulted in a significant reduction in body weight, as well as earlier body hair appearance and opening of the eyes. Sensory motor reflexes exhibited faster responses and significant stimulatory effects in pups exposed to GTE. During the adolescent period, male and female offspring exhibited increased locomotor activity (on PD 22), reduced anxiety and fear (on PD 25), and enhanced memory and learning abilities (on PD 30), all in both GTE treated groups. All blood counts (RBCs, WBCs, Hb, and platelets), and glucose, cholesterol, triglyceride, and low density lipoprotein concentrations were significantly lower in the GTE-treated pups; however, there was no effect on high density lipoprotein levels.ConclusionOur data provide evidence that the high dose of GTE (50 g/L) had higher anxiolytic properties and positive effects on locomotor activities and sensory motor reflexes, as well as learning and memory of the offspring than the low dose of GTE (20 g/L).

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Section: Discussionsupporting

confidence: 91%

Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development

et al. 2017

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“…; Souza et al . ). In addition, rats treated with 15 mg/kg/day caffeine during the neonatal period exhibited reduced expression of TH in the carotid body (Bairam et al .…”

Section: Discussionmentioning

confidence: 97%

Caffeine exposure alters adenosine system and neurochemical markers during retinal development

Brito

Pereira-Figueiredo

Socodato

et al. 2016

Journal of Neurochemistry

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Evidence points to beneficial properties of caffeine in the adult central nervous system, but teratogenic effects have also been reported. Caffeine exerts most of its effects by antagonizing adenosine receptors, especially A 1 and A 2A subtypes. In this study, we evaluated the role of caffeine on the expression of components of the adenosinergic system in the developing avian retina and the impact of caffeine exposure upon specific markers for classical neurotransmitter systems. Caffeine exposure (5-30 mg/kg by in ovo injection) to 14-day-old chick embryos increased the expression of A 1 receptors and concomitantly decreased A 2A adenosine receptors expression after 48 h. Accordingly, caffeine (30 mg/kg) increased receptors from 18 and 24 h. Kinetic assays of [ 3 H]-S-(4-nitrobenzyl)-6-thioinosine binding to the equilibrative adenosine transporter ENT1 revealed an increase in B max with no changes in K d , an effect accompanied by an increase in adenosine uptake. Immunohistochemical analysis showed a decrease in retinal content of tyrosine hydroxylase, calbindin and choline acetyltransferase, but not Brn3a, after 48 h of caffeine injection. Furthermore, retinas exposed to caffeine had increased levels of phosphorylated extracellular signalregulated kinase and cAMP-response element binding protein.Overall, we show an in vivo regulation of the adenosine system, extracellular signal-regulated kinase and cAMPresponse element binding protein function and protein expression of specific neurotransmitter systems by caffeine in the developing retina.

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“…Ethological studies have been commonly conducted when investigating new substances in order to define its effects on behavior (Gauvin et al, 2016). Opposite effects have been observed when testing different substances of diet; caffeine consumption during pregnancy have been associated to delayed neuromotor development in rats (Souza et al, 2015), while a goat milk lipid diet during pregnancy have been associated to accelerated physical development and reflex maturation in rats (Soares et al, 2014). It is worthy to state that the present study is the first to observe the effects of maternal exercise before and during pregnancy on developmental behavior pattern.…”

Section: Discussionmentioning

confidence: 99%

Swimming exercise before and during pregnancy: Promising preventive approach to impact offspring's health

Klein

Hözer

Couto-Pereira

et al. 2018

Intl J of Devlp Neuroscience

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Several environmental factors affect child development, such as the intrauterine environment during the embryonic and fetal development and early postnatal environment provided by maternal behavior. Although mechanistic effects of maternal exercise on offspring health improvement are not yet completely understood, the number of reports published demonstrating the positive influence of maternal exercise have increase. Herein, we addressed issues related to early postnatal environment provided by maternal behavior and early developmental physical landmarks, sensorimotor reflexes, and motor movements ontogeny. In brief, adult female rats underwent involuntary swimming exercise, in a moderated intensity, one week before mating and throughout pregnancy, 30 min a day, 5 days a week. Maternal exercised dams have unchanged gestational outcomes compared to sedentary dams. We found no differences concerning the frequency of pup-directed behavior displayed by dams. However, sedentary dams displayed a poorer pattern of maternal care quality during dark cycle than exercised dams. Physical landmarks and sensorimotor reflexes development of female and male littermates did not differ between maternal groups. Developmental motor parameters such as immobility, lateral head movements, head elevation, pivoting, rearing with forelimb support and crawling frequencies did not differ between groups. Pups born to exercised dams presented higher frequency of walking and rearing on the hind legs. These data suggest that female and male littermates of exercised group present a high frequency of exploratory behavior over sedentary littermates. Taken together, the present findings reinforce that maternal exercise throughout pregnancy represent a window of opportunity to improve offspring's postnatal health.

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Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring

Cited by 30 publications

References 78 publications

Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development

Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development

Caffeine exposure alters adenosine system and neurochemical markers during retinal development

Swimming exercise before and during pregnancy: Promising preventive approach to impact offspring's health

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