Maternal Complications and Perinatal Outcomes Associated with Gestational Hypertension and Severe Preeclampsia in Taiwanese Women

Liu, Ching-Ming; Cheng, Po‐Jen; Chang, Shuenn‐Dyh

doi:10.1016/s0929-6646(08)60126-6

Cited by 67 publications

(70 citation statements)

References 17 publications

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“…6 The present study has found that the group with proteinuria was 11 times more likely to have stillbirths as compared to those without proteinuria (p<0.001; OR=11). These findings are also in accordance with the earlier studies done by Liu CM et al and Dhananjay BS et al 3,6 Though the incidence of stillbirth was seen to be higher in this study.…”

Section: Discussionsupporting

confidence: 94%

“…3 Hence this study is contemplated to be carried out in women with pregnancy induced hypertension and preeclampsia in the background of local ethnicity. Study of the role of proteinuria in predicting maternal and perinatal complications will aid in clinical management by identifying the high risk women who may need aggressive management and the low risk women in whom unnecessary interventions may be avoided.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal and perinatal outcome in pregnancy induced hypertension and preeclampsia

Pairu

Kn²,

George

2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Maternal and perinatal outcome in pregnancy induced hypertension and preeclampsia

Pairu

Kn²,

George

2016

Int J Reprod Contracept Obstet Gynecol

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“…Consequences of pregnancy-related hypertension include increased risk of abruptio placentae, disseminated intravascular coagulation, cerebral hemorrhage, hepatic failure, and acute renal failure. 5 Furthermore, elevated blood pressure in pregnancy can be part of preeclampsia and eclampsia, which carry maternal mortality rates of 10% to 15%, and future risk for cardiovascular disease. Systolic and diastolic blood pressure normally fall in early pregnancy by 5-10 mm Hg, reaching a mean nadir of 105/60 mm Hg, and then gradually rise to pre-pregnancy values by term.…”

Section: Sleep and Hypertension In Pregnancymentioning

confidence: 99%

“…Gestational hypertension, defi ned as a blood pressure higher than 140/90 diagnosed after 20 weeks of gestation, is associated with fetal growth restriction and abruptio placentae and can predispose to preeclampsia, as well as cardiovascular disease later in lif e. 1,[4][5][6] There are few studies evaluating the link between sleep and blood pressure during pregnancy. In this paper, we fi rst review the relationship between sleep and blood pressure in non-pregnant adults.…”

mentioning

confidence: 99%

“…Repeated episodes of hypoxia and reoxygenation have also been shown to be associated with endocrine and metabolic disturbance, as well as elevated risk for metabolic syndrome and cardiovascular disease in OSA patients. 5,6,32,33 SDB has also been shown to be an independent risk factor for hypertension. [34][35][36] Indeed, treatment of SDB using positive airway pressure is associated with a reduction in incident hypertension and a significant improvement in hypertensive patients.…”

mentioning

confidence: 99%

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Sleep and Pregnancy-Induced Hypertension: A Possible Target for Intervention?

Haney

Buysse²,

Okun³

2013

Journal of Clinical Sleep Medicine

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Sleep disturbances in the general population are associated with elevated blood pressure. This may be due to several mechanisms, including sympathetic activation and hypothalamic-pituitary-adrenal (HPA) axis disturbance. Elevated blood pressure in pregnancy can have devastating effects on both maternal and fetal health and is associated with increased risk for preeclampsia and poor delivery outcomes. Preliminary evidence suggests that mechanisms linking sleep and blood pressure in the general population may also hold in the pregnant population. However, the effects of disturbed sleep on physiologic mechanisms that may directly infl uence blood pressure in pregnancy have not been well studied. The role that sleep disturbance plays in gestational blood pressure elevation and its subsequent consequences warrant further investigation. This review evaluates the current literature on sleep disturbance and elevated blood pressure in pregnancy and proposes possible treatment interventions. T he association between sleep disturbances and elevated blood pressure has been extensively studied in the general population. However, relatively few studies have investigated this relationship in the pregnant population. Pregnancy predisposes women to a variety of sleep disturbances.1,2 Similar to non-pregnant individuals, sleep disturbance in pregnancy may be a risk factor for elevated blood pressure, which can lead to maternal and fetal morbidity . 3,4Gestational hypertension, defi ned as a blood pressure higher than 140/90 diagnosed after 20 weeks of gestation, is associated with fetal growth restriction and abruptio placentae and can predispose to preeclampsia, as well as cardiovascular disease later in lif e. 1,[4][5][6] There are few studies evaluating the link between sleep and blood pressure during pregnancy. In this paper, we fi rst review the relationship between sleep and blood pressure in non-pregnant adults. We then outline factors that predispose pregnant women to poor sleep. We conclude with a review of the emerging literature on the associations between sleep and blood pressure in pregnancy. SLEEP AND BLOOD PRESSURE IN THE NON-PREGNANT POPULATIONIn the U.S. the average sleep duration has decreased by 1.5-2 h/night, with > 30% of Americans sleeping < 6 h/night. 7This phenomenon and the concurrent increase in hypertension intimated a possible link between sleep duration and blood pressure. Recently, a series of epidemiological papers have noted an association between sleep duration (both short and long) and elevated blood press ure [8][9][10][11] ; for example, the Sleep Heart Health Study reported that participants who slept < 5 or ≥ 9 h/night had a greater frequency of hypertension than individuals sleeping

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Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

Nomura

Roshan

Janssen

et al. 2017

Arch Gynecol Obstet

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Purpose Preeclampsia is known to be a leading cause of mortality and morbidity among mothers and their infants. Approximately 3–8% of all pregnancies in the US are complicated by preeclampsia and another 5–7% by hypertensive symptoms. However, less is known about its long-term influence on infant neurobehavioral development. The current review attempts to demonstrate new evidence for imprinting gene dysregulation caused by hypertension, which may explain the link between maternal preeclampsia and neurocognitive dysregulation in offspring. Method Pub Med and Web of Science databases were searched using the terms “preeclampsia,” “gestational hypertension,” “imprinting genes,” “imprinting dysregulation,” and “epigenetic modification,” in order to review the evidence demonstrating associations between preeclampsia and suboptimal child neurodevelopment, and suggest dysregulation of placental genomic imprinting as a potential underlying mechanism. Results The high mortality and morbidity among mothers and fetuses due to preeclampsia is well known, but there is little research on the long-term biological consequences of preeclampsia and resulting hypoxia on the fetal/child neurodevelopment. In the past decade, accumulating evidence from studies that transcend disciplinary boundaries have begun to show that imprinted genes expressed in the placenta might hold clues for a link between preeclampsia and impaired cognitive neurodevelopment. A sudden onset of maternal hypertension detected by the placenta may result in misguided biological programming of the fetus via changes in the epigenome, resulting in suboptimal infant development. Conclusion Furthering our understanding of the molecular and cellular mechanisms through which neurodevelopmental trajectories of the fetus/infant are affected by preeclampsia and hypertension will represent an important first step toward preventing adverse neurodevelopment in infants.

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Maternal Complications and Perinatal Outcomes Associated with Gestational Hypertension and Severe Preeclampsia in Taiwanese Women

Abstract: Proteinuria may play a role in the progression of gestational hypertension to severe forms of preeclampsia associated with subsequent maternal complications and extremely-low-birth-weight babies.

Cited by 67 publications

References 17 publications

Maternal and perinatal outcome in pregnancy induced hypertension and preeclampsia

Maternal and perinatal outcome in pregnancy induced hypertension and preeclampsia

Sleep and Pregnancy-Induced Hypertension: A Possible Target for Intervention?

Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes

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