Maternal complications in women presenting with first trimester threatened miscarriage.

Abstract

Objective: To determine the frequency of miscarriage, hypertensive disorder of pregnancy, placental abruption and preterm birth in women with first trimester threatened miscarriage. Study Design: Cross-sectional study. Setting: Department of Obstetric & Gynaecology, Sir Syed Hospital and Pakistan Naval Ship Shifa Hospital (Karachi). Period: April, 2021 to March, 2022. Material & Methods: Ninety two women 18-40 year old, diagnosed as threatened miscarriage at ≤ 13 weeks based on history, examination and ultrasound were included in the study after informed consent and followed till delivery. Women with genital infection, other form of miscarriage and multiple pregnancy were excluded. Data recorded from hospital documents. Maternal age, parity and Gestational age assessed. Miscarriage, hypertensive disorder of pregnancy, placental abruption, preterm birth and PPROM expressed as frequency and percentages. Logistic regression analysis performed. Chi square test (x2) used and P-value ≤ 0.05 taken as significant. Results: Mean age of women was 29.21±3.49 years. Mean parity was 2.65±1.15. Mean Gestational age at presentation was 7.96±1.78 weeks. 11.11%. (10/90) cases had miscarriage. 88.88% (80/90) women continued their pregnancy. 42.5% (34/80) had hypertensive disorder of pregnancy. 20% had pregnancy induced hypertension and 22.5% had pre-eclampsia. Preterm birth was seen in 26.3% (21/80). Frequency of PPROM and placental abruption was 6.3% (5/80) each. Women of 21-25 yr age were more at risk of hypertensive disorder of pregnancy than other age groups. There was no significant affect of maternal age and parity on preterm birth and placental abruption. Frequency of Preterm birth was 38.4% in women with hypertensive disorder, more than 2 times higher than non-hypertensives (17.4%) and found significant (P-value=0.043). Conclusion: Hypertensive disorder of pregnancy was the most common maternal complication observed in women who had threatened miscarriage in first trimester. Preterm birth had significant association with hypertensive disorder of pregnancy.