Maternal concentration of polychlorinated biphenyls and dichlorodiphenyl dichlorethylene and birth weight in Michigan fish eaters: a cohort study

Karmaus, Wilfried; Zhu, Xiaobei

doi:10.1186/1476-069x-3-1

Cited by 92 publications

(82 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Maternal serum and umbilical cord blood levels of p,p´-DDT and/or p,p´-dichlorodiphenyldichloroethylene (p,p´-DDE), a metabolite of p,p´-DDT, have been associated in some studies with preterm birth (Longnecker et al 2001;Ribas-Fito et al 2002;Saxena et al 1980;Wasserman et al 1982), decreased birth weight (O'Leary et al 1970;Weisskopf et al 2005), or intrauterine growth retardation (Longnecker et al 2001;Siddiqui et al 2003). In other studies, increased levels of p,p´-DDT and/or p,p´-DDE in maternal serum, cord blood, or breast milk were not related to either decreased infant birth weight (Bjerregaard and Hansen 2000;Dewailly et al 1993b;Gladen et al 2003;Karmaus and Zhu 2004;Needham et al 2005;Rogan et al 1986) or preterm birth (Berkowitz et al 1996;Needham et al 2005;Torres-Arreola et al 2003).…”

mentioning

confidence: 76%

Association of in Utero Organochlorine Pesticide Exposure and Fetal Growth and Length of Gestation in an Agricultural Population

Fenster¹,

Eskenazi²,

Anderson³

et al. 2005

Epidemiology

View full text Add to dashboard Cite

From 1940 through the 1970s, organochlorine compounds were widely used as insecticides in the United States. Thereafter, their use was severely restricted after recognition of their persistence in the environment, their toxicity in animals, and their potential for endocrine disruption. Although substantial evidence exists for the fetal toxicity of organochlorines in animals, information on human reproductive effects is conflicting. We investigated whether infants' length of gestation, birth weight, and crown-heel length were associated with maternal serum levels of 11 different organochlorine pesticides: p,p´-dichlorodiphenyltrichloroethane (p,p´-DDT), p,p´-dichlorodiphenyldichloroethylene (p,p´-DDE), o,p´-dichlorodiphenyltrichloroethane (o,p´-DDT), hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCCH), γ-hexachlorocyclohexane (γ-HCCH), dieldrin, heptachlor epoxide, oxychlordane, trans-nonachlor, and mirex. Our subjects were a birth cohort of 385 low-income Latinas living in the Salinas Valley, an agricultural community in California. We observed no adverse associations between maternal serum organochlorine levels and birth weight or crown-heel length. We found decreased length of gestation with increasing levels of lipid-adjusted HCB (adjusted β = -0.47 weeks; p = 0.05). We did not find reductions in gestational duration associated with any of the other organochlorine pesticides. Our finding of decreased length of gestation related to HCB does not seem to have had clinical implications for this population, given its relatively low rate of preterm delivery (6.5%).

show abstract

mentioning

confidence: 76%

Association of in Utero Organochlorine Pesticide Exposure and Fetal Growth and Length of Gestation in an Agricultural Population

Fenster¹,

Eskenazi²,

Anderson³

et al. 2005

Epidemiology

View full text Add to dashboard Cite

show abstract

“…Several studies of lower-level PCBs exposure during pregnancy observed associations with decreased birth weight and other growth parameters (Fein et al, 1984;Rylander et al, 1996: Rylander et al, 1998Patandin et al, 1998;Karmaus and Zhu, 2004;Hertz-Picciotto et al, 2005;Sagiv et al, 2007;Sonneborn et al, 2008). In the Lake Michigan fish consumer study, cord serum PCBs levels predicted LBW and smaller birth head circumference (Fein et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

View full text Add to dashboard Cite

Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes.However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies.A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood.Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% CI: -387.4 to -61.5).Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.

show abstract

“…A meta-analysis comparing prenatal PCB exposure and birth weight effects across 12 European birth cohorts found a significant negative correlation between cord blood PCB levels and birth weight [11]. Multiple studies have confirmed that low-level PCB exposure during the perinatal period can significantly affect fetal growth and birth weight [12,[14][15][16][17][18][19], although other studies found that PCBs have minimal or no effect [20,21]. Nonetheless, the decreased body weight can persist to preschool ages and is concomitant with hypotonia and diminished physical activity [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…The developmental origins of health and disease hypothesis, derived from the thrifty phenotype hypothesis put forth by Barker and Hales in 1992 [5], postulates that low birth weight offspring can result from insufficient nutrition in the intrauterine environment, leading to metabolic and other health derangements later in life [5][6][7][8][9][10]. In fact, maternal serum PCB levels in humans negatively correlate with infant birth weight and gestational age [11][12][13][14][15][16][17]. A meta-analysis comparing prenatal PCB exposure and birth weight effects across 12 European birth cohorts found a significant negative correlation between cord blood PCB levels and birth weight [11].…”

Section: Introductionmentioning

confidence: 99%

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

2016

View full text Add to dashboard Cite

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose exposure levels are associated with various health hazards. We hypothesized that in utero and lactational exposure to PCBs can cause changes in body composition and obesity in a mouse model. Pregnant mice were exposed biweekly to two concentrations of PCB 126 via oral gavage. Maternal PCB exposure did not result in heavier offspring, however, dose-dependent and sex specific changes in body composition were observed. Female offspring displayed the most susceptibility to PCBinduced alterations in body composition, having less percent lean body mass and increased adiposity compared to females born to control dams, and these effects were largely dosedependent. In contrast to females, and independent of the exposure level of PCB 126, male offspring had reduced lean body mass but no change in fat mass compared to males born to control dams. In conclusion, perinatal PCB 126 exposure did not affect body weight, but rather modulated body composition in a dose-dependent and gender-specific manner.

show abstract

Maternal concentration of polychlorinated biphenyls and dichlorodiphenyl dichlorethylene and birth weight in Michigan fish eaters: a cohort study

Cited by 92 publications

References 54 publications

Association of in Utero Organochlorine Pesticide Exposure and Fetal Growth and Length of Gestation in an Agricultural Population

Association of in Utero Organochlorine Pesticide Exposure and Fetal Growth and Length of Gestation in an Agricultural Population

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

Contact Info

Product

Resources

About