Maternal Consumption of Dairy Products, Calcium, and Vitamin D During Pregnancy and Infantile Allergic Disorders

Abstract

Three of these variants were associated with a significant risk reduction in all 3 variables. Only 2 variants provided similar risk reductions in those who received HN019. CONCLUSIONS. This study found that supplementation with Lactobacillus rhamnosusstrain HN001 could reduce the risk of atopy and eczema development in subjects with TLR genetic variants typically associated with a higher risk of these diseases. REVIEWER COMMENTS. This study highlights the growing interest in the use of probiotics for the prevention and treatment of atopic disorders. Several studies have shown reduction in eczema risk, but the mechanism in which probiotics accomplish this has been unknown. The authors demonstrate the role of probiotic interaction with TLR SNP variants, identifying a novel mechanism through which risk reduction occurs. The study also suggests that this intervention should begin early, during pregnancy, to have significant benefit.

Risk of eczema, wheezing and respiratory tract infections in the first year of life: A systematic review of vitamin D concentrations during pregnancy and at birth

“…Similarly, high levels of maternal vitamin D during pregnancy were associated with lower occurrences of eczema and RTIs in infants [16,23,24]. In contrast, several studies did not support this association and have shown conflicting results [25,26]. To date, the extent vitamin D levels during pregnancy and early postnatal period (e.g., cord blood) affect the development of allergic diseases and RTIs in infants remains unclear.…”