Maternal cytoglobin (CYGB) serum levels in normal and preeclamptic pregnancies

Tayyar, Ahter Tanay; Kozalı, Şükran; Karakuş, Resul; Karakuş, Seren; Yüksel, İlkbal Temel; Dağ, İsmail; Yıldırım, Gonca Yetkin; Demirci, Oya

doi:10.1080/14767058.2017.1421927

Cited by 5 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In severe PE with proteinuria >3 g/L showed that the amount of proteinuria is not associated with severe PE, although proteinuria is detected, prematurity may occur [29]. Serum cytoglobin was significantly more effective and higher in patients with early-onset preeclampsia (EO-PE) and slow onset of preeclampsia (LOPE), compared with healthy pregnant women [30]. Uric acid with proteinuria can identify perinatal risk with high risk with gestational hypertension in women [31].…”

Section: Biomarker In Pementioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Preeclampsia (PE) have a high risk of pregnancy disorder and can cause liver and kidney disease. PE is a dangerous disease in Indonesia with a high risk of cardiovascular death. PE has biomarkers such as proteinuria, blood pressure, dipstick test, renin-angiotensin system, adipsin, calcium/ creatinine (Cr) ratio, albumin/Cr ratio, and uric acid. Apoptosis occurs in the placenta’s PE, where trophoblasts invade and overhaul the uterine spiral artery in the epidermal growth factor signaling system, and the expression of miRNA in PE is targeting genes in a variety of pathophysiological processes can cause kidney and hepatic disease. In this review, we will discuss role of HSP, miRNA, Immunology cell and the risk of kidney and hepatic disease of patient of Preeclampsia.

show abstract

Section: Biomarker In Pementioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…These complications are inversely proportional to the experience of the person who applies the method. Amniotic fluid leak, vaginal bleeding, uterine contractions, chorioamnionitis, sampling failure, miscarriage, fetal loss and possible fetal injuries are among the complications of amniocentesis [3] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of indications and peri-procedural complications of amniocentesis

Wilson¹,

Bhandari²,

Chandwaskar³

et al. 2023

Int. J. Clin. Obstet. Gynaecol.

View full text Add to dashboard Cite

Assessment of indications and peri-procedural complications of amniocentesis. Materials and Methods: Cases were analyzed with some indications such as intermediate or high risk in dual and quadruple marker test, abnormal NT scan or target scan, history of child with congenital anomaly, abnormality in ultrasonography (cystic hygroma, omphalocele, diaphragmatic hernia, etc.) and to which amniocentesis will be applied. Patient and family were informed about the amniocentesis procedure, the role of this method in diagnosis and also its complications before the application. Results: The age and gestational age of the participants were 28.25±2.69 and 16.89±2.15 respectively. Most of the patients 17.14% have Hypothyroidism co morbidity. 65.71% patients show high risk assessment with dual marker & quadruple marker & abnormal NT scan & target scan indication for amniocentesis, followed by h/o child with congenital anomaly (14.2%), couple has thalassemia (11.4%), genetic disorder in family (2.9%) and chromosomal abnormality in previous child (2.9%). There was no complication of amniocentesis. Conclusion: we concluded that the genetic amniocentesis has a high success rate when performed by experienced obstetrician or foetal medicine specialist in 15-20 weeks of gestation. It should be offered to the patients when they have correct indication.

show abstract

“…This imbalance between proinflammatory and anti-inflammatory regulatory cytokines is associated with placental ischemia in preeclampsia during pregnancy. This imbalance worsens as pregnancy progresses, further complicating pregnancy (7). Growth suppression-specific protein 6(Gas6) is a secreted protein encoded by a growth suppressionspecific gene, which is widely found in a variety of tissues, such as the small intestine, lung, kidney, placenta and endothelial cells, and can also be detected in human serum or plasma.…”

Section: Introductionmentioning

confidence: 99%

Expression levels of serum mir-145-5p and Gas6 in women with early-onset preeclampsia and their clinical significance

Huang

Zhang

2022

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Early preeclampsia is a pregnancy-specific clinical disease, its pathogenesis is not clear, and clinical treatment is limited. Therefore, it is particularly important to study the pathogenesis of early preeclampsia, so as to provide evidence for the diagnosis and effective treatment of early preeclampsia. This research was carried out to investigate the expression levels and clinical significance of mir-145-5p and stagflation specific gene 6 (Gas6) in serum of women with early preeclampsia. For this purpose, 142 patients with preeclampsia were divided into the early-onset group (n=78) and the late-onset group (n=64) according to the onset time. Meanwhile, 70 normal pregnant women were selected as the control group. The levels of serum Gas6, mir-145-5p and inflammatory factors were detected. Logistic regression analysis showed that the expression levels of serum gas-6 and serum mir-145-5p were valuable in the diagnosis of early preeclampsia. ROC curve was established to evaluate the diagnostic efficacy of serum Gas6 level in early-onset preeclampsia. Its sensitivity and specificity were 91.23% and 64.2%, respectively, and the cutting value was 255.71pg/mL. The serum Gas6 level was negatively correlated with systolic blood pressure (r=-0.349, P<0.05) and positively correlated with platelet count (r=0.391, P<0.05). Compared with the control group, serum levels of mir-145-5p and TNF-a in women with early-onset preeclampsia were negatively correlated (r=-0.460~0.622, P<0.05). Conclusion: the serum level of Gas6 was reduced in patients with early-onset preeclampsia, and TNF-a inhibited the invasion of SVneo cells by upregulating mir-145-5p.

show abstract

Maternal cytoglobin (CYGB) serum levels in normal and preeclamptic pregnancies

Abstract: Serum CYGB levels were significantly higher in patients with EO-PE and LO-PE as compared to healthy pregnant women.

Cited by 5 publications

References 26 publications

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Assessment of indications and peri-procedural complications of amniocentesis

Expression levels of serum mir-145-5p and Gas6 in women with early-onset preeclampsia and their clinical significance

Contact Info

Product

Resources

About