Maternal cytomegalovirus immune status and hearing loss outcomes in congenital cytomegalovirus-infected offspring

Demmler-Harrison, Gail J.; Miller, Jerry A.

doi:10.1371/journal.pone.0240172

Cited by 26 publications

(17 citation statements)

References 53 publications

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“…In addition, the maternal history of CMV infection had no significant effect on the development of late‐onset SNHL in the current study. A previous study showed that SNHL commonly develops in patients with both symptomatic cCMV infection soon after birth and a history of maternal primary CMV infection 23 . We speculate that maternal CMV infection may produce early symptomatic cCMV infection rather than a late‐onset disorder.…”

Section: Discussionmentioning

confidence: 69%

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The correlation between neonatal parameters and late‐onset inner ear disorders in congenital cytomegalovirus infection: a 10‐year population‐based cohort study

Lee

Huang

et al. 2021

Clinical Otolaryngology

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Objective: To evaluate the correlation of neonatal parameters with late-onset sensorineural hearing loss (SNHL) and vestibular dysfunction in individuals with congenital cytomegalovirus (cCMV) infection using the National Health Insurance Research Database (NHIRD) in Taiwan.Design: Retrospective cohort study. Setting:The whole Taiwanese population.Participants: Patients with related diagnostic codes and examinations in their records were regarded as having cCMV infection. Each subject in that group was matched to 10 control individuals with noncongenital CMV infection on the basis of several neonatal parameters, including low gestational age, low birth weight, low Apgar score, maternal history of CMV infection and prolonged cCMV infection. A total of 5893 and 58 930 participants were enrolled in the study and control groups, respectively. Main outcome measures:The main outcomes were the development of SNHL and the development of vestibular dysfunction within one year after birth as reflected by diagnostic codes and specific examinations. Cox proportional hazard regression was used to calculate the adjusted hazard ratio (HR) and 95% confidence interval (CI) of each primary outcome between the two groups.Results: Overall, 109 and 397 episodes of SNHL developed in the study group and the control group, respectively, and the study group demonstrated a significantly higher incidence of SNHL (adjusted HR: 2.56; 95% CI: 2.07-3.18). In addition, similar incidence rates of vestibular dysfunction were found in the study group and the control group, with 7 and 90 events, respectively (adjusted HR: 0.77; 95% CI: 0.36-1.67). In subgroup analyses, a higher incidence of SNHL was correlated with lower gestational age (GA) (adjusted HR: 2.09; 95% CI: 1.29-3.39), lower birth weight (BW) (adjusted HR: 2.05; 95% CI: 1.28-3.30) and prolonged cCMV infection (adjusted HR: 3.92; 95% CI: 1.95-7.88).Conclusions: Low GA, low BW and a long disease course are significantly correlated with late-onset SNHL in cCMV infection.

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Section: Discussionmentioning

confidence: 69%

“…A previous study showed that SNHL commonly develops in patients with both symptomatic cCMV infection soon after birth and a history of maternal primary CMV infection. 23 We speculate that maternal CMV infection may produce early symptomatic cCMV infection rather than a late-onset disorder.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 87%

The correlation between neonatal parameters and late‐onset inner ear disorders in congenital cytomegalovirus infection: a 10‐year population‐based cohort study

Lee

Huang

et al. 2021

Clinical Otolaryngology

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“…In a retrospective case study by Kim et al ( 16 ), 11 out of 58 children (19%) with cCMV had SNHL, but the majority of them were not identified as having hearing loss (HL) during the hospital hearing screening, suggesting SNHL can occur later in life for this population even after passing a newborn hearing screening. Demmler-Harrison et al ( 14 ) studied the long-term effects of cCMV-related HL, finding 20% of asymptomatic cCMV cases born with normal hearing to have late-onset SNHL. In a sample of 237 participants, 46% of children with primary cCMV were born with SNHL and 54% of children with primary cCMV had delayed onset SNHL, suggesting SNHL might not appear until up to 18 years of age for this population.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, children identified as having hearing loss before 6 months of age are predicted to have increased speech and language performance compared to children identified after 6 months of age ( 3 ). Therefore, Demmler-Harrison et al ( 14 ) believe early identification of infants with symptomatic and asymptomatic cCMV is important for detecting SNHL and providing early monitoring and intervention.…”

Section: Discussionmentioning

confidence: 99%

Congenital Cytomegalovirus and Human Immunodeficiency Virus: Effects on Hearing, Speech and Language Development, and Clinical Outcomes in Children

et al. 2021

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Prenatal infections can have adverse effects on an infant's hearing, speech, and language development. Congenital cytomegalovirus (CMV) and human immunodeficiency virus (HIV) are two such infections that may lead to these complications, especially when left untreated. CMV is commonly associated with sensorineural hearing loss in children, and it can also be associated with anatomical abnormalities in the central nervous system responsible for speech, language, and intellectual acquisition. In terms of speech, language, and hearing, HIV is most associated with conductive and/or sensorineural hearing loss and expressive language deficits. Children born with these infections may benefit from cochlear implantation for severe to profound sensorineural hearing losses and/or speech therapy for speech/language deficits. CMV and HIV simultaneously present in infants has not been thoroughly studied, but one may hypothesize these speech, language, and hearing deficits to be present with potentially higher severity. Early identification of the infection in combination with early intervention strategies yields better results for these children than no identification or intervention. The purpose of this review was to investigate how congenital CMV and/or HIV may affect hearing, speech, and language development in children, and the importance of early identification for these populations.

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“…Thus, among the non-genetic causes of neurosensory deafness, congenital CMV infection ranks first, and is also the leading among the known viral causes of mental retardation. In about 10-15% of newborns, congenital CMV infection is accompanied by clinical symptoms, more often it is neurosensory deafness, increase in the size of internal organs, intracranial calcifications and chorioretinia [28,29].…”

Section: Review and Discussionmentioning

confidence: 99%

Peculiarities of the Prevalence of Intrauterine Infections at the Present Stage

Vygivska

Руденко²,

Radzishevska

et al. 2021

Wiad Lek

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The aim: According to the literature sources to summarize statistics on the prevalence of intrauterine infection and its impact on pregnancy and the condition of newborns at the present stage. Materials and methods: The article analyzes 35 literature sources (scientific publications) from 2000 to 2021, indexed in international scientometric database and covers the incidence of intrauterine infections in countries with different income levels, as well as their impact on pregnancy, childbirth and the condition of newborns. Conclusions: The main task of obstetrics and gynecology at the present stage is to reduce reproductive losses, which necessitates further study of the etiology of IUI, especially in low- and middle-income countries. The screening for IUIs during pregnancy is cost-effective because treatment of the effects of IUIs requires disproportionately greater resources.

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Maternal cytomegalovirus immune status and hearing loss outcomes in congenital cytomegalovirus-infected offspring

Abstract: The purpose of this study is to determine the relationship between maternal primary and recurrent CMV infection during pregnancy, symptoms at birth in the newborn, and long term hearing loss through18 years of age.

Cited by 26 publications

References 53 publications

The correlation between neonatal parameters and late‐onset inner ear disorders in congenital cytomegalovirus infection: a 10‐year population‐based cohort study

The correlation between neonatal parameters and late‐onset inner ear disorders in congenital cytomegalovirus infection: a 10‐year population‐based cohort study

Congenital Cytomegalovirus and Human Immunodeficiency Virus: Effects on Hearing, Speech and Language Development, and Clinical Outcomes in Children

Peculiarities of the Prevalence of Intrauterine Infections at the Present Stage

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